Comparison of TAM/M2 gene expression profile resulting from different systems
| . | DcR3-treated MDMs . | Generally M2 phenotype (Mantovani et al8 ) . | IL-4 polarized M2 (Martinez et al58 ) . | TAMs by ovarian cancer (Hagemann et al56 ) . |
|---|---|---|---|---|
| Membrane receptor | ||||
| Mannose receptor | Increased | Increased | Increased | Increased |
| M160 | Increased | Not mentioned | Increased | Not mentioned |
| Fcγ-Rs:CD16/32/64 | Decreased | Decreased | Not identified | Not mentioned |
| CD80 | Decreased | Decreased | Not identified | Not mentioned |
| Cytokine and receptor | ||||
| TNF-α | Decreased | Decreased | Not identified | Increased |
| IL-1 | Decreased | Decreased | Not identified | Not mentioned |
| IL-6 | Decreased | Decreased | Decreased | Not mentioned |
| IL1RN | Increased | Increased | Not identified | Not mentioned |
| IL1R2 | Increased | Increased | Not identified | Not mentioned |
| Chemokine and chemokine receptor | ||||
| CCL22 | Increased | Increased | Not identified | Increased |
| CXCL2 | Decreased | Not mentioned | Not identified | Decreased |
| Effector molecule | ||||
| iNOS | Decreased | Decreased | Not identified | Not mentioned |
| Arginase-1 | Increased* | Increased | Not identified | Not mentioned |
| MMP7 | Increased | Increased | Not identified | Increased |
| MMP9 | Increased | Increased | Not identified | Increased |
| . | DcR3-treated MDMs . | Generally M2 phenotype (Mantovani et al8 ) . | IL-4 polarized M2 (Martinez et al58 ) . | TAMs by ovarian cancer (Hagemann et al56 ) . |
|---|---|---|---|---|
| Membrane receptor | ||||
| Mannose receptor | Increased | Increased | Increased | Increased |
| M160 | Increased | Not mentioned | Increased | Not mentioned |
| Fcγ-Rs:CD16/32/64 | Decreased | Decreased | Not identified | Not mentioned |
| CD80 | Decreased | Decreased | Not identified | Not mentioned |
| Cytokine and receptor | ||||
| TNF-α | Decreased | Decreased | Not identified | Increased |
| IL-1 | Decreased | Decreased | Not identified | Not mentioned |
| IL-6 | Decreased | Decreased | Decreased | Not mentioned |
| IL1RN | Increased | Increased | Not identified | Not mentioned |
| IL1R2 | Increased | Increased | Not identified | Not mentioned |
| Chemokine and chemokine receptor | ||||
| CCL22 | Increased | Increased | Not identified | Increased |
| CXCL2 | Decreased | Not mentioned | Not identified | Decreased |
| Effector molecule | ||||
| iNOS | Decreased | Decreased | Not identified | Not mentioned |
| Arginase-1 | Increased* | Increased | Not identified | Not mentioned |
| MMP7 | Increased | Increased | Not identified | Increased |
| MMP9 | Increased | Increased | Not identified | Increased |
Arginase-1 up-regulation was observed on TAMs from DcR3 transgenic mice but not found in DcR3-treated human MDMs.