Table 3 KDE analysis results in... | American Society of Hematology

Table 3

KDE analysis results in IGHV3-21/IGLV3-21 discordant cases and IGHV1-69/IGLV3-09

Sample ID	IGK allele configuration	IGKV	IGJK	Frame	% IGKV homology	FR, P	CDR, P	Replacement mutation		Silent mutation		% IGHV homology	% IGLV homology
Sample ID	IGK allele configuration	IGKV	IGJK	Frame	% IGKV homology	FR, P	CDR, P	FR	CDR	FR	CDR	% IGHV homology	% IGLV homology
CLL1 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-39	IGJK3	+	96.1	0.009	0.026	3	4	4	0	95.4	98.9
	IGKV-KDE	IGKV2D-29		−	100
CLL2 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-17	IGJK4	+	93.6	0.001	0.013	5	6	6	1	94.7	99.6
	IGKV-KDE	IGKV2-30		−	100
CLL3 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-39	IGJK5	+	96.4	0.003	0.017	2	4	4	0	96.8	99.3
	IGKV-KDE	IGKV2-28		−	100
CLL4 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-9	IGJK4	+	96.8	0.009	0.012	2	3	4	0	96.8	98.9
	IGKV-KDE	IGKV1-33		−	100
CLL5 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV3-11	IGJK5	+	97.6	0.041	0.031	2	3	2	0	97.2	98.3
	IGKV-KDE	IGKV1-33		−	100
CLL6 IGHV3-21/IGLV3-21	IGKV-J	IGKV1-33	IGJK2	−	100							97.5	98.6
	IGKV-KDE	IGKV1-27		−	100
CLL7 IGHV3-21/IGLV3-21	IGKV-J	IGKV2-18	IGJK4	−	100							97.5	98.3
	IGKV-KDE	IGKV1-27		−	100
CLL1 IGHV1-69/IGLV3-09	IGKV-KDE	IGKV1-16		−	100							100	100
	IGKV-KDE	IGKV3-15		−	100
CLL2 IGHV1-69/IGLV3-09	IGKV-J	IGKV1-27	IGJK4	−	100							99.3	100
	IGKV-KDE	IGKV3-7		−	100
CLL3 IGHV1-69/IGLV3-09	IGKV-KDE	IGKV1-9		−	100							100	100
	IGKV-KDE	IGKV4-1		−	100
CLL4 IGHV1-69/IGLV3-09	IGKV-J	IGKV1-33	IGJK3	−	100							100	100
	IGKV-KDE	IGKV3-11		−	100

Sample ID	IGK allele configuration	IGKV	IGJK	Frame	% IGKV homology	FR, P	CDR, P	Replacement mutation		Silent mutation		% IGHV homology	% IGLV homology
Sample ID	IGK allele configuration	IGKV	IGJK	Frame	% IGKV homology	FR, P	CDR, P	FR	CDR	FR	CDR	% IGHV homology	% IGLV homology
CLL1 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-39	IGJK3	+	96.1	0.009	0.026	3	4	4	0	95.4	98.9
	IGKV-KDE	IGKV2D-29		−	100
CLL2 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-17	IGJK4	+	93.6	0.001	0.013	5	6	6	1	94.7	99.6
	IGKV-KDE	IGKV2-30		−	100
CLL3 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-39	IGJK5	+	96.4	0.003	0.017	2	4	4	0	96.8	99.3
	IGKV-KDE	IGKV2-28		−	100
CLL4 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV1-9	IGJK4	+	96.8	0.009	0.012	2	3	4	0	96.8	98.9
	IGKV-KDE	IGKV1-33		−	100
CLL5 IGHV3-21/IGLV3-21	VK-JK-KDE	IGKV3-11	IGJK5	+	97.6	0.041	0.031	2	3	2	0	97.2	98.3
	IGKV-KDE	IGKV1-33		−	100
CLL6 IGHV3-21/IGLV3-21	IGKV-J	IGKV1-33	IGJK2	−	100							97.5	98.6
	IGKV-KDE	IGKV1-27		−	100
CLL7 IGHV3-21/IGLV3-21	IGKV-J	IGKV2-18	IGJK4	−	100							97.5	98.3
	IGKV-KDE	IGKV1-27		−	100
CLL1 IGHV1-69/IGLV3-09	IGKV-KDE	IGKV1-16		−	100							100	100
	IGKV-KDE	IGKV3-15		−	100
CLL2 IGHV1-69/IGLV3-09	IGKV-J	IGKV1-27	IGJK4	−	100							99.3	100
	IGKV-KDE	IGKV3-7		−	100
CLL3 IGHV1-69/IGLV3-09	IGKV-KDE	IGKV1-9		−	100							100	100
	IGKV-KDE	IGKV4-1		−	100
CLL4 IGHV1-69/IGLV3-09	IGKV-J	IGKV1-33	IGJK3	−	100							100	100
	IGKV-KDE	IGKV3-11		−	100