Normal hematopoiesis in SOCS3ΔSB/ΔSB mice
| Parameter . | SOCS3+/+ . | SOCS3ΔSB/ΔSB . |
|---|---|---|
| Peripheral blood | ||
| Platelet count, ×106/mL | 1061 ± 127 | 1180 ± 146 |
| Hematocrit, % | 49 ± 2 | 49 ± 2 |
| White blood cell count, ×106/mL | 7 ± 1 | 6 ± 2 |
| Neutrophil count, % | 10 ± 4 | 13 ± 5 |
| Lymphocyte count, % | 86 ± 4 | 82 ± 4 |
| Monocyte count, % | 2 ± 2 | 3 ± 2 |
| Eosinophil count, % | 2 ± 2 | 2 ± 2 |
| Bone marrow | ||
| Cellularity per femur, ×106 | 17.6 ± 5.6 | 18.4 ± 2.9 |
| Blast count, % | 2 ± 1 | 2 ± 1 |
| Promyelocyte count, % | 6 ± 4 | 7 ± 1 |
| Neutrophil count, % | 24 ± 0 | 33 ± 7 |
| Lymphocyte count, % | 15 ± 11 | 8 ± 4 |
| Monocyte count, % | 7 ± 7 | 6 ± 2 |
| Eosinophil count, % | 2 ± 1 | 3 ± 1 |
| Nucleated RBC count, % | 44 ± 10 | 41 ± 15 |
| Spleen | ||
| Mass, mg | 75.5 ± 0.7 | 111.7 ± 12.5* |
| Cellularity, ×108 | 1.5 ± 0.1 | 1.7 ± 0.4 |
| Blast count, % | 0 ± 0 | 0 ± 0 |
| Promyelocyte count, % | 0 ± 0 | 0 ± 0 |
| Neutrophil count, % | 11 ± 6 | 11 ± 2 |
| Lymphocyte count, % | 70 ± 4 | 69 ± 3 |
| Monocyte count, % | 7 ± 7 | 5 ± 7 |
| Eosinophil count, % | 0 ± 0 | 0 ± 0 |
| Nucleated RBC count, % | 12 ± 2 | 15 ± 8 |
| Thymus | ||
| Mass, mg | 62.0 ± 11.3 | 65.3 ± 7.8 |
| Parameter . | SOCS3+/+ . | SOCS3ΔSB/ΔSB . |
|---|---|---|
| Peripheral blood | ||
| Platelet count, ×106/mL | 1061 ± 127 | 1180 ± 146 |
| Hematocrit, % | 49 ± 2 | 49 ± 2 |
| White blood cell count, ×106/mL | 7 ± 1 | 6 ± 2 |
| Neutrophil count, % | 10 ± 4 | 13 ± 5 |
| Lymphocyte count, % | 86 ± 4 | 82 ± 4 |
| Monocyte count, % | 2 ± 2 | 3 ± 2 |
| Eosinophil count, % | 2 ± 2 | 2 ± 2 |
| Bone marrow | ||
| Cellularity per femur, ×106 | 17.6 ± 5.6 | 18.4 ± 2.9 |
| Blast count, % | 2 ± 1 | 2 ± 1 |
| Promyelocyte count, % | 6 ± 4 | 7 ± 1 |
| Neutrophil count, % | 24 ± 0 | 33 ± 7 |
| Lymphocyte count, % | 15 ± 11 | 8 ± 4 |
| Monocyte count, % | 7 ± 7 | 6 ± 2 |
| Eosinophil count, % | 2 ± 1 | 3 ± 1 |
| Nucleated RBC count, % | 44 ± 10 | 41 ± 15 |
| Spleen | ||
| Mass, mg | 75.5 ± 0.7 | 111.7 ± 12.5* |
| Cellularity, ×108 | 1.5 ± 0.1 | 1.7 ± 0.4 |
| Blast count, % | 0 ± 0 | 0 ± 0 |
| Promyelocyte count, % | 0 ± 0 | 0 ± 0 |
| Neutrophil count, % | 11 ± 6 | 11 ± 2 |
| Lymphocyte count, % | 70 ± 4 | 69 ± 3 |
| Monocyte count, % | 7 ± 7 | 5 ± 7 |
| Eosinophil count, % | 0 ± 0 | 0 ± 0 |
| Nucleated RBC count, % | 12 ± 2 | 15 ± 8 |
| Thymus | ||
| Mass, mg | 62.0 ± 11.3 | 65.3 ± 7.8 |
Peripheral blood and organ weight data shown as the mean and standard deviation of 20 wild-type (SOCS3+/+) and 15 SOCS3ΔSB/ΔSB mice. The cellularity of bone marrow and spleen is the mean and standard deviation of data from 2 SOCS3+/+ or 3 SOCS3ΔSB/ΔSB mice. All mice were 8 to 12 weeks of age.
RBC indicates red blood cell.
P < .05.