Patient characteristics before and 3 months after retreatment
| Retreatment . | Patient 1* . | Patient 2* . | Patient 3* . | |||
|---|---|---|---|---|---|---|
| Before . | After . | Before . | After . | Before . | After . | |
| Clinical symptoms | Weight loss, sweats | None | Weight loss, lethargy, sweats | None | Fevers, lethargy, weight loss | None |
| Histologic features | MCD KSHV-positive | — | MCD KSHV-positive | — | MCD KSHV-positive | — |
| Radiologic features | LNs | Partial response | HSM and LNs | Partial response | Widespread LNs | Partial response |
| CD4 count | 375 | 336 | 196 | 192 | 634 | 540 |
| LDH, U/L | 499 | 295 | 616 | 417 | 322 | 306 |
| Albumin, g/L | 29 | 42 | 26 | 34 | 31 | 42 |
| CRP | 152 | 4 | 31 | 4 | 12 | 3 |
| Hemoglobin, mmol/L | 8.8 | 14.5 | 10.1 | 14.3 | 8.1 | 13 |
| KSHV levels | 15 000 | ND | 150 000 | ND | 400 000 | ND |
| Retreatment . | Patient 1* . | Patient 2* . | Patient 3* . | |||
|---|---|---|---|---|---|---|
| Before . | After . | Before . | After . | Before . | After . | |
| Clinical symptoms | Weight loss, sweats | None | Weight loss, lethargy, sweats | None | Fevers, lethargy, weight loss | None |
| Histologic features | MCD KSHV-positive | — | MCD KSHV-positive | — | MCD KSHV-positive | — |
| Radiologic features | LNs | Partial response | HSM and LNs | Partial response | Widespread LNs | Partial response |
| CD4 count | 375 | 336 | 196 | 192 | 634 | 540 |
| LDH, U/L | 499 | 295 | 616 | 417 | 322 | 306 |
| Albumin, g/L | 29 | 42 | 26 | 34 | 31 | 42 |
| CRP | 152 | 4 | 31 | 4 | 12 | 3 |
| Hemoglobin, mmol/L | 8.8 | 14.5 | 10.1 | 14.3 | 8.1 | 13 |
| KSHV levels | 15 000 | ND | 150 000 | ND | 400 000 | ND |
— indicates not applicable; LNs, lymph nodes; HSM, hepatosplenomegaly; and ND, not detectable.
This patient is in remission for a second time with a follow-up of 24 to 36 months after initial diagnosis.