Cox proportional hazards model hazard ratios for death from all causes in patients with diffuse large B-cell lymphoma
| Parameters . | All patients . | Non-GCB subtype . | GCB subtype . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| EBV status | .544 | .045 | .091 | |||
| EBER ISH − | — | 1.0 | — | |||
| EBER ISH + | — | 2.9 (1.1-8.1) | — | |||
| Performance status | <.001 | .003 | <.001 | |||
| ECOG, 0 to 1 | 1.0 | 1.0 | 18.1 (7.0-47.0) | |||
| ECOG, 2 to 4 | 3.4 (2.0-5.9) | 3.3 (1.5-7.0) | ||||
| Lactic dehydrogenase | <.001 | .006 | .154 | |||
| ULN or below | 1.00 | 1.0 | — | |||
| Over ULN | 3.2 (1.8-5.5) | 3.1 (1.3-7.3) | — | |||
| No. of extranodal sites | <.001 | .083 | .060 | |||
| 0 or 1 | 1.0 | — | — | |||
| 1 or more | 2.9 (1.7-5.0) | — | — | |||
| Age, years | <.001 | .059 | .198 | |||
| 60 years old or less | 1.0 | — | — | |||
| Over 60 years old | 2.7 (1.6-5.1) | — | — | |||
| B symptom | .246 | .006 | .474 | |||
| Absent | — | 1.0 | — | |||
| Present | — | 3.3 (1.5-7.0) | — | |||
| Ann Arbor stage | .161 | .085 | .020 | |||
| Stage I/II | — | — | 1.0 | |||
| Stage III/IV | — | — | 3.0 (1.2-7.5) | |||
| Parameters . | All patients . | Non-GCB subtype . | GCB subtype . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| EBV status | .544 | .045 | .091 | |||
| EBER ISH − | — | 1.0 | — | |||
| EBER ISH + | — | 2.9 (1.1-8.1) | — | |||
| Performance status | <.001 | .003 | <.001 | |||
| ECOG, 0 to 1 | 1.0 | 1.0 | 18.1 (7.0-47.0) | |||
| ECOG, 2 to 4 | 3.4 (2.0-5.9) | 3.3 (1.5-7.0) | ||||
| Lactic dehydrogenase | <.001 | .006 | .154 | |||
| ULN or below | 1.00 | 1.0 | — | |||
| Over ULN | 3.2 (1.8-5.5) | 3.1 (1.3-7.3) | — | |||
| No. of extranodal sites | <.001 | .083 | .060 | |||
| 0 or 1 | 1.0 | — | — | |||
| 1 or more | 2.9 (1.7-5.0) | — | — | |||
| Age, years | <.001 | .059 | .198 | |||
| 60 years old or less | 1.0 | — | — | |||
| Over 60 years old | 2.7 (1.6-5.1) | — | — | |||
| B symptom | .246 | .006 | .474 | |||
| Absent | — | 1.0 | — | |||
| Present | — | 3.3 (1.5-7.0) | — | |||
| Ann Arbor stage | .161 | .085 | .020 | |||
| Stage I/II | — | — | 1.0 | |||
| Stage III/IV | — | — | 3.0 (1.2-7.5) | |||
— indicates not applicable; HR, hazard ratio.