Clinical characteristics of the de novo AML samples
| . | Discovery . | CALGB . |
|---|---|---|
| Cytogenetic subgroup (%) | ||
| Normal | 35 (37.2) | 41 (43.6) |
| t(15;17) only | 12 (12.8) | 20 (21.3) |
| t(8;21) only | 1 (1.1) | 3 (3.2) |
| inv (16) only | 2 (2.1) | 6 (6.4) |
| Trisomy 8 only | 5 (5.3) | 0 (0.0) |
| 5q-/-5 only | 1 (1.1) | 0 (0.0) |
| 7q-/-7 only | 1 (1.1) | 0 (0.0) |
| Complex karyotype, typical* | 2 (2.1) | 0 (0.0) |
| Complex karyotype, atypical* | 10 (10.6) | 0 (0.0) |
| Other | 25 (26.6) | 24 (25.5) |
| FAB subtype (%) | ||
| M0 | 6 (6.4) | 5 (5.3) |
| M1 | 18 (19.1) | 18 (19.1) |
| M2 | 21 (22.3) | 23 (24.5) |
| M3 | 17 (18.1) | 23 (24.5) |
| M4 | 18 (19.1) | 25 (26.6) |
| M5 | 9 (9.6) | 0 (0.0) |
| M6 | 3 (3.2) | 0 (0.0) |
| M7 | 2 (2.1) | 0 (0.0) |
| Age, y (range) | 52.8 (16-81) | 40.3 (22-70) |
| Sex, no. (%) | ||
| Male | 56 (59.6) | 54 (57.4) |
| Female | 38 (40.4) | 40 (42.6) |
| Ethnicity, no. (%) | ||
| Asian | 1 (1.1) | 4 (4.2) |
| Black | 9 (9.6) | 6 (6.4) |
| White | 83 (88.3) | 70 (74.5) |
| Hispanic | 1 (1.1) | 11 (11.7) |
| Other | 0 (0.0) | 3 (3.2) |
| . | Discovery . | CALGB . |
|---|---|---|
| Cytogenetic subgroup (%) | ||
| Normal | 35 (37.2) | 41 (43.6) |
| t(15;17) only | 12 (12.8) | 20 (21.3) |
| t(8;21) only | 1 (1.1) | 3 (3.2) |
| inv (16) only | 2 (2.1) | 6 (6.4) |
| Trisomy 8 only | 5 (5.3) | 0 (0.0) |
| 5q-/-5 only | 1 (1.1) | 0 (0.0) |
| 7q-/-7 only | 1 (1.1) | 0 (0.0) |
| Complex karyotype, typical* | 2 (2.1) | 0 (0.0) |
| Complex karyotype, atypical* | 10 (10.6) | 0 (0.0) |
| Other | 25 (26.6) | 24 (25.5) |
| FAB subtype (%) | ||
| M0 | 6 (6.4) | 5 (5.3) |
| M1 | 18 (19.1) | 18 (19.1) |
| M2 | 21 (22.3) | 23 (24.5) |
| M3 | 17 (18.1) | 23 (24.5) |
| M4 | 18 (19.1) | 25 (26.6) |
| M5 | 9 (9.6) | 0 (0.0) |
| M6 | 3 (3.2) | 0 (0.0) |
| M7 | 2 (2.1) | 0 (0.0) |
| Age, y (range) | 52.8 (16-81) | 40.3 (22-70) |
| Sex, no. (%) | ||
| Male | 56 (59.6) | 54 (57.4) |
| Female | 38 (40.4) | 40 (42.6) |
| Ethnicity, no. (%) | ||
| Asian | 1 (1.1) | 4 (4.2) |
| Black | 9 (9.6) | 6 (6.4) |
| White | 83 (88.3) | 70 (74.5) |
| Hispanic | 1 (1.1) | 11 (11.7) |
| Other | 0 (0.0) | 3 (3.2) |
CALGB indicates Cancer and Leukemia Group B.
Defined based on the criteria outlined by Bacher et al.37