Frontline treatment and relapse treatment in subgroups defined by submicroscopic BM involvement (cut-off: 10−4)
| Treatment . | Submicroscopic BM involvement . | P . | ||
|---|---|---|---|---|
| Total, no. (%) . | Less than 10−4, no. (%) . | At least 10−4, no. (%) . | ||
| Total | 64 (100) | 18 (100) | 46 (100) | — |
| Frontline protocol | .14 | |||
| ALL-BFM 90/96 | 20 (31) | 5 (28) | 15 (33) | — |
| ALL-BFM 2000 | 14 (22) | 3 (17) | 11 (24) | — |
| EORTC 58–881/952 | 16 (25) | 8 (44) | 8 (17) | — |
| COALL-92/97 | 14 (22) | 2 (11) | 12 (26) | — |
| Cranial irradiation frontline | .93 | |||
| No | 42 (78) | 11 (79) | 31 (78) | — |
| Yes | 12 (22) | 3 (21) | 9 (23) | — |
| No data | 10 | 4 | 6 | — |
| Relapse protocol | .023 | |||
| ALL-REZ BFM 90/96 | 16 (25) | 1 (6) | 15 (33) | — |
| ALL-REZ BFM P02/02 | 32 (50) | 9 (50) | 23 (50) | — |
| COOPRALL | 16 (25) | 8 (44) | 8 (17) | — |
| Cranial irradiation relapse | .30 | |||
| No | 19 (40) | 7 (50) | 12 (36) | — |
| Yes* | 18 (39) | 4 (29) | 14 (42) | — |
| TBI† | 10 (21) | 3 (21) | 7 (21) | — |
| No data | 17 | 4 | 13 | — |
| SCT | .30 | |||
| No | 47 (75) | 14 (78) | 33 (73) | — |
| Allogeneic‡ | 7 (11) | 2 (11) | 5 (11) | — |
| Autologous | 9 (14) | 2 (11) | 7 (16) | — |
| No data | 1 | 0 | 1 | — |
| Treatment . | Submicroscopic BM involvement . | P . | ||
|---|---|---|---|---|
| Total, no. (%) . | Less than 10−4, no. (%) . | At least 10−4, no. (%) . | ||
| Total | 64 (100) | 18 (100) | 46 (100) | — |
| Frontline protocol | .14 | |||
| ALL-BFM 90/96 | 20 (31) | 5 (28) | 15 (33) | — |
| ALL-BFM 2000 | 14 (22) | 3 (17) | 11 (24) | — |
| EORTC 58–881/952 | 16 (25) | 8 (44) | 8 (17) | — |
| COALL-92/97 | 14 (22) | 2 (11) | 12 (26) | — |
| Cranial irradiation frontline | .93 | |||
| No | 42 (78) | 11 (79) | 31 (78) | — |
| Yes | 12 (22) | 3 (21) | 9 (23) | — |
| No data | 10 | 4 | 6 | — |
| Relapse protocol | .023 | |||
| ALL-REZ BFM 90/96 | 16 (25) | 1 (6) | 15 (33) | — |
| ALL-REZ BFM P02/02 | 32 (50) | 9 (50) | 23 (50) | — |
| COOPRALL | 16 (25) | 8 (44) | 8 (17) | — |
| Cranial irradiation relapse | .30 | |||
| No | 19 (40) | 7 (50) | 12 (36) | — |
| Yes* | 18 (39) | 4 (29) | 14 (42) | — |
| TBI† | 10 (21) | 3 (21) | 7 (21) | — |
| No data | 17 | 4 | 13 | — |
| SCT | .30 | |||
| No | 47 (75) | 14 (78) | 33 (73) | — |
| Allogeneic‡ | 7 (11) | 2 (11) | 5 (11) | — |
| Autologous | 9 (14) | 2 (11) | 7 (16) | — |
| No data | 1 | 0 | 1 | — |