In vitro sensitivity of lymphoid cell lines to free drug and ADC
| . | IC50, nM . | |||||
|---|---|---|---|---|---|---|
| BJAB-luc . | SU-DHL-4 . | DoHH2 . | Granta-519 . | Ramos . | Jurkat . | |
| L-DM1 | 0.89 (0.08) | 1.73 (0.06) | 0.15 (0.007) | 0.35 (0.01) | 0.24 (0.16) | 0.49 (0.084) |
| MMAE | 0.53 (0.007) | 0.66 (0.006) | 0.45 (0.08) | 0.36 (0.001) | 0.31 (0.02) | 0.44 (0.13) |
| MMAF | 60.9 (4.03) | 99.4 (3.7) | 46.0 (9.16) | 43.9 (2.6) | 43.22 (6.7) | 53.7 (4.31) |
| anti-CD79 (SN8)-MC-MMAF* | 6.84 (0.59) | 1.85 (0.08) | 1.56 (0.13) | 10.38 (0.35) | 0.34 (0.02) | >200 |
| anti-CD79 (SN8)-MCC-DM1* | 9.65 (0.01) | 3.96 (0.30) | 10.35 (3.61) | 10.51 (0.12) | 1.00 (0.14) | 63.3 (0.90) |
| . | IC50, nM . | |||||
|---|---|---|---|---|---|---|
| BJAB-luc . | SU-DHL-4 . | DoHH2 . | Granta-519 . | Ramos . | Jurkat . | |
| L-DM1 | 0.89 (0.08) | 1.73 (0.06) | 0.15 (0.007) | 0.35 (0.01) | 0.24 (0.16) | 0.49 (0.084) |
| MMAE | 0.53 (0.007) | 0.66 (0.006) | 0.45 (0.08) | 0.36 (0.001) | 0.31 (0.02) | 0.44 (0.13) |
| MMAF | 60.9 (4.03) | 99.4 (3.7) | 46.0 (9.16) | 43.9 (2.6) | 43.22 (6.7) | 53.7 (4.31) |
| anti-CD79 (SN8)-MC-MMAF* | 6.84 (0.59) | 1.85 (0.08) | 1.56 (0.13) | 10.38 (0.35) | 0.34 (0.02) | >200 |
| anti-CD79 (SN8)-MCC-DM1* | 9.65 (0.01) | 3.96 (0.30) | 10.35 (3.61) | 10.51 (0.12) | 1.00 (0.14) | 63.3 (0.90) |
Numbers in parentheses represent standard deviation of quadruplicate assays.
*Concentration of ADC given as the concentration of the conjugated cytotoxic.