Table 1

Hamster heart graft survival in C57BL/6 nude mice receiving various treatments

GroupRecipientsAdditional treatmentnGraft survival, mean d ± SD
C57BL/6 nude No 20 5.1 ± 0.5 
C57BL/6 nude Splenectomy at days −90, −14, 0, 2, and 3 24 No rejection* 
C57BL/6 nude splenectomized Day-0 transfer of splenocytes from naive syngeneic mice No rejection* 
C57BL/6 nude splenectomized Day-0 transfer of splenocytes from xenograft-rejecting syngeneic mice No rejection* 
C57BL/6 nude splenectomized Transfer of serum from xenograft-rejecting syngeneic mice Hyperacute rejection 
C57BL/6 nude 2 Gy TBI at day −2 No rejection* 
C57BL/6 nude 2 Gy TBI at day −14 No rejection* 
C57BL/6 nude 2 Gy TBI at day −28 6 ± 1.3 
GroupRecipientsAdditional treatmentnGraft survival, mean d ± SD
C57BL/6 nude No 20 5.1 ± 0.5 
C57BL/6 nude Splenectomy at days −90, −14, 0, 2, and 3 24 No rejection* 
C57BL/6 nude splenectomized Day-0 transfer of splenocytes from naive syngeneic mice No rejection* 
C57BL/6 nude splenectomized Day-0 transfer of splenocytes from xenograft-rejecting syngeneic mice No rejection* 
C57BL/6 nude splenectomized Transfer of serum from xenograft-rejecting syngeneic mice Hyperacute rejection 
C57BL/6 nude 2 Gy TBI at day −2 No rejection* 
C57BL/6 nude 2 Gy TBI at day −14 No rejection* 
C57BL/6 nude 2 Gy TBI at day −28 6 ± 1.3 
*

Experiments were terminated at 60 days after hamster heart transplantation.

Rejection occurred within 1 to 4 hours.

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