Table 1 Neutrophil and platelet recovery... | American Society of Hematology

Table 1

Neutrophil and platelet recovery in mice that underwent transplantation with mobilized PBSCs

Mobilizer	Days to more than 500 ANCs	Days to PLT Recovery
Mobilizer	Days to more than 500 ANCs	20%	40%	80%
PBS	Over 95% mortality day 14	—	—	—
G-CSF	17	20	26	39
GROβ	15^*	16^*	18^*	23^*
GROβ_Δ4	15^*	16^*	18^*	23^*
GROβ + G-CSF	13^*	16^*	20^*	29^*
GROβ_Δ4 + G-CSF	13^*	16^*	20^*	29^*

Mobilizer	Days to more than 500 ANCs	Days to PLT Recovery
Mobilizer	Days to more than 500 ANCs	20%	40%	80%
PBS	Over 95% mortality day 14	—	—	—
G-CSF	17	20	26	39
GROβ	15^*	16^*	18^*	23^*
GROβ_Δ4	15^*	16^*	18^*	23^*
GROβ + G-CSF	13^*	16^*	20^*	29^*
GROβ_Δ4 + G-CSF	13^*	16^*	20^*	29^*

Lethally irradiated mice underwent transplantation with 2 × 10⁶ PBMCs mobilized by G-CSF, GROβ, GROβ_Δ4, or G-CSF plus GROβ/GROβ_Δ4. Hematologic recovery in recipient mice was evaluated by enumeration of neutrophil (ANC) and platelet (PLT) count on alternate days using a Hemavet Mascot hematology analyzer equipped with veterinary software (CDC Technologies, Oxford, CT). The rates of hematologic recovery for G-CSF, GROβ, and GROβ_Δ4 alone and in combination with G-CSF were determined by nonlinear regression analysis as previously described.⁷

—indicates over 95% mortality by day 14.

P < .05 compared with G-CSF.

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