Table 1 Fibrin clot stiffness with and... | American Society of Hematology

Table 1

Fibrin clot stiffness with and without cross-linking

	Normal recombinant fibrinogen	γK406R	γQ398N/Q399N/K406R	Plasma fibrinogen
Number	3	3	3	3
G′, dyne/cm² ± SD, before cross-linking	28.3 ± 2.9	18.1 ± 2.1	16.7 ± 1.6	23.5 ± 2.2
G′, dyne/cm² ± SD, after cross-linking	98.9 ± 17.6*†	29.9 ± 2.3†‡	41.2 ± 2.1†	64.4 ± 2.9†
Fold increase of G′ after cross-linking	3.5×	1.5×	2.5×	2.8×

	Normal recombinant fibrinogen	γK406R	γQ398N/Q399N/K406R	Plasma fibrinogen
Number	3	3	3	3
G′, dyne/cm² ± SD, before cross-linking	28.3 ± 2.9	18.1 ± 2.1	16.7 ± 1.6	23.5 ± 2.2
G′, dyne/cm² ± SD, after cross-linking	98.9 ± 17.6*†	29.9 ± 2.3†‡	41.2 ± 2.1†	64.4 ± 2.9†
Fold increase of G′ after cross-linking	3.5×	1.5×	2.5×	2.8×

Stiffer than cross-linked γK406R, γQ398N/Q399N/K406R, and plasma-purified fibrin by one-way ANOVA (P < .05).

Stiffer after cross-linking by independent t test (P < .05).

Less stiff than plasma and normal recombinant fibrinogen (P < .05).