Comparison of known risk factors, treatment groups, and clinical outcome of patients with high versus low MRD at day 30
| Variables . | Low MRD, < 10−3 (%) . | High MRD, ≥ 10−3 (%) . | P . |
|---|---|---|---|
| Total number | 246 | 38 | — |
| Risk group | Chi-square, < .001 | ||
| Standard risk | 160 (65.0) | 14 (36.8) | |
| High risk | 86 (35.0) | 24 (63.2) | |
| WBC count, × 109/L | Chi-square, .02 | ||
| Lower than 50 000 | 211 (85.8) | 27 (71.1) | |
| 50 000 or higher | 35 (14.2) | 11 (28.9) | |
| Age, y | Chi-square, .007 | ||
| 0 to younger than 1 | 7 (2.9) | 4 (10.5) | |
| 1 to younger than 10 | 205 (83.3) | 24 (63.2) | |
| 10 or older to younger than 18 | 34 (13.8) | 10 (26.3) | |
| Sex | Chi-square, .61 | ||
| Male | 125 (50.8) | 21 (55.3) | |
| Female | 121 (49.2) | 17 (44.7) | |
| Asparaginase treatment | Chi-square, .04 | ||
| Randomized to E coli | 82 (33.3) | 5 (13.2) | |
| Randomized to Erwinia | 64 (26.0) | 12 (31.6) | |
| Direct assigned E coli | 100 (40.7) | 21 (55.3) | |
| Relapse | Log rank, < .001 | ||
| Yes | 29 (11.8) | 27 (71.0) | |
| No | 217 (88.2) | 11 (29.0) |
| Variables . | Low MRD, < 10−3 (%) . | High MRD, ≥ 10−3 (%) . | P . |
|---|---|---|---|
| Total number | 246 | 38 | — |
| Risk group | Chi-square, < .001 | ||
| Standard risk | 160 (65.0) | 14 (36.8) | |
| High risk | 86 (35.0) | 24 (63.2) | |
| WBC count, × 109/L | Chi-square, .02 | ||
| Lower than 50 000 | 211 (85.8) | 27 (71.1) | |
| 50 000 or higher | 35 (14.2) | 11 (28.9) | |
| Age, y | Chi-square, .007 | ||
| 0 to younger than 1 | 7 (2.9) | 4 (10.5) | |
| 1 to younger than 10 | 205 (83.3) | 24 (63.2) | |
| 10 or older to younger than 18 | 34 (13.8) | 10 (26.3) | |
| Sex | Chi-square, .61 | ||
| Male | 125 (50.8) | 21 (55.3) | |
| Female | 121 (49.2) | 17 (44.7) | |
| Asparaginase treatment | Chi-square, .04 | ||
| Randomized to E coli | 82 (33.3) | 5 (13.2) | |
| Randomized to Erwinia | 64 (26.0) | 12 (31.6) | |
| Direct assigned E coli | 100 (40.7) | 21 (55.3) | |
| Relapse | Log rank, < .001 | ||
| Yes | 29 (11.8) | 27 (71.0) | |
| No | 217 (88.2) | 11 (29.0) |
— indicates not applicable.