Table 4

Telomere lengths in DC patients compared with non-DC patients

Cell typeDC patients
Non-DC patients
DC patients vs non-DC patients
N abnormalN abnormalOR95% CISens (%)Spec (%)PPV (%)NPV (%)
Granulocytes 24/25 11/42 68 8-2867 96 74 69 97 
Lymphocytes* 24/26* 4/44* 120* 17-1215* 92* 91* 86* 95* 
CD45RA+/CD20− naïve T cells* 25/26* 3/45* 350* 31-14665* 96* 93* 89* 98* 
CD45− memory T cells 22/26 4/45 56 11-325 85 91 85 91 
CD20+ B cells* 24/26* 5/41* 86* 13-855* 92* 88* 83* 95* 
CD57+ NK/NKT cells 18/25 0/42 1/∞ — 72 100 100 86 
Leukocytes 26/26 6/45 ∞ — 100 87 81 100 
Granulocytes, lymphocytes 23/25 3/42 150 19-1592 92 93 88 95 
Granulocytes, naïve T cells, B cells 23/25 1/41 460 33-19338 92 98 96 95 
Lymphocytes, naïve T cells, B cells* 24/26* 1/41* 480* 35-20144* 92* 98* 96* 95* 
Cell typeDC patients
Non-DC patients
DC patients vs non-DC patients
N abnormalN abnormalOR95% CISens (%)Spec (%)PPV (%)NPV (%)
Granulocytes 24/25 11/42 68 8-2867 96 74 69 97 
Lymphocytes* 24/26* 4/44* 120* 17-1215* 92* 91* 86* 95* 
CD45RA+/CD20− naïve T cells* 25/26* 3/45* 350* 31-14665* 96* 93* 89* 98* 
CD45− memory T cells 22/26 4/45 56 11-325 85 91 85 91 
CD20+ B cells* 24/26* 5/41* 86* 13-855* 92* 88* 83* 95* 
CD57+ NK/NKT cells 18/25 0/42 1/∞ — 72 100 100 86 
Leukocytes 26/26 6/45 ∞ — 100 87 81 100 
Granulocytes, lymphocytes 23/25 3/42 150 19-1592 92 93 88 95 
Granulocytes, naïve T cells, B cells 23/25 1/41 460 33-19338 92 98 96 95 
Lymphocytes, naïve T cells, B cells* 24/26* 1/41* 480* 35-20144* 92* 98* 96* 95* 

N indicates number; abnormal, below 1st percentile (numerator and denominator indicate the number abnormal/number assayed for each cell type); OR, odds ratio in favor of being a DC patient; CI, confidence interval; Sens, sensitivity, the proportion of those with disease who were correctly identified; Spec, specificity, the proportion of nondiseased people who were correctly identified as negative; PPV, positive predictive value, the proportion of those who test positive who actually have the disease; NPV, negative predictive value, the proportion of those who test negative who do not have the disease; —, not applicable.

*

The leukocyte subsets with the best performance characteristics.

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