Telomere lengths in DC patients compared with DC relatives
| Cell type . | DC patients . | DC relatives . | DC patients vs DC relatives . | |||||
|---|---|---|---|---|---|---|---|---|
| N abnormal . | N abnormal . | OR . | 95% CI . | Sens (%) . | Spec (%) . | PPV (%) . | NPV (%) . | |
| Granulocytes | 24/25 | 8/51 | 129 | 15-5419 | 96 | 84 | 75 | 98 |
| Lymphocytes* | 24/26* | 2/54* | 312* | 34-3694* | 92* | 96* | 92* | 96* |
| CD45RA+/CD20− naïve T cells* | 25/26* | 3/54* | 425* | 37-17734* | 96* | 94* | 89* | 98* |
| CD45− memory T cells | 22/26 | 2/54 | 143 | 21-1443 | 85 | 96 | 92 | 93 |
| CD20+ B-cells* | 24/26* | 4/54* | 150* | 22-1508* | 92* | 93* | 86* | 96* |
| CD57+ NK/NKT cells | 18/25 | 1/50 | 129 | 14-5347 | 72 | 98 | 95 | 88 |
| Total leukocytes | 26/26 | 5/54 | ∞ | — | 100 | 91 | 84 | 100 |
| Granulocytes, lymphocytes | 23/25 | 2/51 | 282 | 30-3349 | 92 | 96 | 92 | 96 |
| Granulocytes, naïve T cells, B cells | 23/25 | 2/51 | 282 | 30-3349 | 92 | 96 | 92 | 96 |
| Lymphocytes, naïve T cells, B cells* | 24/26* | 2/54* | 312* | 34-3694* | 92* | 96* | 92* | 96* |
| Cell type . | DC patients . | DC relatives . | DC patients vs DC relatives . | |||||
|---|---|---|---|---|---|---|---|---|
| N abnormal . | N abnormal . | OR . | 95% CI . | Sens (%) . | Spec (%) . | PPV (%) . | NPV (%) . | |
| Granulocytes | 24/25 | 8/51 | 129 | 15-5419 | 96 | 84 | 75 | 98 |
| Lymphocytes* | 24/26* | 2/54* | 312* | 34-3694* | 92* | 96* | 92* | 96* |
| CD45RA+/CD20− naïve T cells* | 25/26* | 3/54* | 425* | 37-17734* | 96* | 94* | 89* | 98* |
| CD45− memory T cells | 22/26 | 2/54 | 143 | 21-1443 | 85 | 96 | 92 | 93 |
| CD20+ B-cells* | 24/26* | 4/54* | 150* | 22-1508* | 92* | 93* | 86* | 96* |
| CD57+ NK/NKT cells | 18/25 | 1/50 | 129 | 14-5347 | 72 | 98 | 95 | 88 |
| Total leukocytes | 26/26 | 5/54 | ∞ | — | 100 | 91 | 84 | 100 |
| Granulocytes, lymphocytes | 23/25 | 2/51 | 282 | 30-3349 | 92 | 96 | 92 | 96 |
| Granulocytes, naïve T cells, B cells | 23/25 | 2/51 | 282 | 30-3349 | 92 | 96 | 92 | 96 |
| Lymphocytes, naïve T cells, B cells* | 24/26* | 2/54* | 312* | 34-3694* | 92* | 96* | 92* | 96* |
N indicates number; abnormal, below 1st percentile (numerator and denominator indicate the number abnormal/number assayed for each cell type); OR, odds ratio in favor of being a DC patient; CI, confidence interval; Sens, sensitivity, the proportion of those with disease who were correctly identified; Spec, specificity, the proportion of nondiseased people who were correctly identified as negative; PPV, positive predictive value, the proportion of those who test positive who actually have the disease; NPV, negative predictive value, the proportion of those who test negative who do not have the disease; —, not applicable.
The leukocyte subsets with the best performance characteristics.