Differentially expressed genes of known function in the ″migration″ cluster
| Accession no. . | Gene description/gene name . | Function . | Expression . |
|---|---|---|---|
| Tumorigenesis | |||
| AK124593 | Patched homolog 1 (Drosophila)/PTCH1 | Tumor suppressor gene, Adhesion/migration | − |
| NM_014269 | Metallopeptidase domain 29/ADAM29 | Adhesion | − |
| NM_012342 | BMP and activin membrane-bound inhibitor homolog/BAMBI | Cytoskeletal organization | − |
| NM_006889 | CD86 | Cell-cell interactions, costimulation | − |
| NM_002209 | Integrin αL/ITGAL/CD11a | Adhesion | + |
| NM_001079 | ZAP-70 | Intracellular signaling | + |
| NM_144710 | Septin 10/SEPT10 | Migration | + |
| Metabolism | |||
| NM_000237 | Lipoprotein lipase/LPL | Lipoprotein metabolism | + |
| NM_080283 | ATP-binding cassette, subfamily A, member 9/ABCA9 | Cholesterol responsive gene | + |
| NM_005504 | Branched chain aminotransferase 1/BCAT1 | Amino acid transamination | + |
| NM_002343 | Lactotransferrin/LTF | Iron metabolism | + |
| NM_144651 | Peroxidasin homolog-like (Drosophila)/PXDNL | Ion binding | − |
| NM_173497 | HECT domain containing 2/HECTD2 | Ubiquitin cycle | − |
| Transcription | |||
| NM_173464/AK026733 | L(3)mbt-like 4 (Drosophila)/L3MBTL4 | Transcription factor activity | + |
| NM_175065 | Histone cluster 2, H2ab/HIST2H2AB | Transcription regulation, DNA repair | − |
| Accession no. . | Gene description/gene name . | Function . | Expression . |
|---|---|---|---|
| Tumorigenesis | |||
| AK124593 | Patched homolog 1 (Drosophila)/PTCH1 | Tumor suppressor gene, Adhesion/migration | − |
| NM_014269 | Metallopeptidase domain 29/ADAM29 | Adhesion | − |
| NM_012342 | BMP and activin membrane-bound inhibitor homolog/BAMBI | Cytoskeletal organization | − |
| NM_006889 | CD86 | Cell-cell interactions, costimulation | − |
| NM_002209 | Integrin αL/ITGAL/CD11a | Adhesion | + |
| NM_001079 | ZAP-70 | Intracellular signaling | + |
| NM_144710 | Septin 10/SEPT10 | Migration | + |
| Metabolism | |||
| NM_000237 | Lipoprotein lipase/LPL | Lipoprotein metabolism | + |
| NM_080283 | ATP-binding cassette, subfamily A, member 9/ABCA9 | Cholesterol responsive gene | + |
| NM_005504 | Branched chain aminotransferase 1/BCAT1 | Amino acid transamination | + |
| NM_002343 | Lactotransferrin/LTF | Iron metabolism | + |
| NM_144651 | Peroxidasin homolog-like (Drosophila)/PXDNL | Ion binding | − |
| NM_173497 | HECT domain containing 2/HECTD2 | Ubiquitin cycle | − |
| Transcription | |||
| NM_173464/AK026733 | L(3)mbt-like 4 (Drosophila)/L3MBTL4 | Transcription factor activity | + |
| NM_175065 | Histone cluster 2, H2ab/HIST2H2AB | Transcription regulation, DNA repair | − |
The + or − in the “Expression” column represents the status of gene expression in migration+ versus migration− CLL samples.