Characteristics of the patient sample and experiments performed
ID no. . | Age, y . | Sex . | Years from diagnosis . | Therapy . | IgV mutations, % . | VH usage . | FISH . | CD38, % . | ZAP-70, % . | Sig . | IL-2 . | Arr . | Mig . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 68 | M | 1 | NT | 10.5 | V3–72, D1–20, J6 | Normal | 1.0 | 0.7 | – | – | – | + |
2 | 55 | F | 4 | NT | 5.7 | V3–72, D3–22, J4 | del 13 | 1.3 | 0.2 | – | – | – | + |
3 | 67 | F | 19 | CHL | 3.7 | V1–2, D4–17, J3 | del 13 | 1.5 | 9.0 | + | + | + | + |
4 | 77 | M | 11 | NT | 4.8 | V3–11, D6–6, J4 | del 13, 17 | 2.0 | 0.0 | – | + | – | + |
5 | 69 | M | 5 | NT | 5.4 | V3–7, D2–8, J4 | Normal | 2.0 | 0.3 | – | + | + | + |
6 | 70 | F | 6 | NT | 6.1 | V3–30, D2–2, J4 | Normal | 2.0 | 6.2 | – | – | – | + |
7 | 61 | F | 9 | CHL | 8.1 | V1–2 | del 13 | 2.0 | 4.5 | + | – | + | – |
8 | 47 | M | 7 | T | 6.8 | V4–61, D3–10, J4 | ND | 2.0 | 0.1 | – | – | – | + |
9 | 69 | F | 7 | NT | 10.2 | V3–23, D3–10, J4 | del 13 | 3.0 | 1.0 | – | + | – | + |
10 | 73 | F | 7 | CHL | 9.5 | V3–30, J5 | del 13 | 5.2 | 0.2 | – | – | – | + |
11 | 64 | F | UN | UN | 6.3 | V3–30 | del 13 | 6.5 | 0.7 | – | – | + | + |
12 | 68 | F | 1 | NT | 3.8 | V3–13, J5 | del 13 | 6.7 | 0.9 | – | + | – | – |
13 | 70 | F | 8 | NT | 5.4 | V3–30 | del 13 | 10.4 | 0.8 | – | – | – | + |
14 | 64 | F | 6 | NT | ND | ND | Normal | 12.0 | 0.3 | – | – | – | + |
15 | 65 | F | 12 | T | 8.0 | V3–23, J5 | del 13 | 12.9 | 0.1 | – | + | – | + |
16 | 63 | M | 6 | NT | 5.1 | V4–34 | Normal | 13.0 | 1.0 | + | – | – | – |
17 | 75 | M | 4 | NT | 7.8 | V3–11, D3–10, J4 | ND | 15.0 | 2.4 | – | – | – | + |
18 | 74 | F | 5 | CHL | 3.7 | V1–3 | del 17 | 18.0 | 0.8 | + | – | – | – |
19 | 71 | F | 14 | CHL | 10.4 | V3–9, D2–2, J4 | del 17 | 1.9 | 1.7 | – | – | + | + |
20 | 54 | F | 2 | NT | 2.4 | V3–74, D3–10, J4 | Normal | 10.0 | 5.0 | – | – | + | + |
21 | 78 | M | 11 | NT | 1.0 | V1–69, D4–17, J4 | tri 12 | 21.0 | 14.3 | + | + | + | + |
22 | 54 | M | 6 | T | 0.9 | V3–13, D3–22, J5b | del 13 | 24.5 | 35.4 | + | – | + | + |
23 | 80 | M | 4 | T | 0.0 | V1–2 | del 13, 17 | 52.6 | 12.0 | + | + | + | + |
24 | 72 | F | 8 | T | 0.0 | V3–11, D3–10, J5 | Normal | 56.0 | 21.4 | + | – | + | + |
25 | 51 | M | 4 | T | 0.3 | V1–69, D5–5, J6 | ND | 36.0 | 10.6 | + | + | – | + |
26 | 60 | M | 2 | T | 0.7 | V3–74, D7–27, J4 | del 13 | 45.0 | 35.4 | – | – | – | + |
27 | 67 | M | 6 | NT | 0.7 | V4–59 | Normal | 78.5 | 20.3 | + | – | + | – |
28 | 74 | F | 10 | T | 1.0 | V3–48 | Normal | 68.0 | 82.0 | + | – | – | + |
29 | 78 | M | 3 | T | 1.4 | V3–48 | Normal | 70.0 | 34.2 | – | + | – | + |
30 | 86 | M | 3 | T | 0.3 | V1–69, D2–15, J6 | ND | 66.0 | 20.0 | + | + | + | + |
31 | 70 | F | 11 | T | 1.0 | V1–69, D3–16, J6 | tri 12 | 90.0 | 34.4 | – | – | – | – |
32 | 62 | M | 2 | NT | 0.3 | V3–11, D3–22, J4 | del 11 | 98.0 | 17.0 | – | – | – | + |
33 | 83 | M | 2 | NT | 3.0 | V3–30, D2–8 | tri 12 | 74.0 | 51.0 | – | + | – | + |
34 | 64 | M | 4 | NT | 5.8 | V3–74, D1–26, J5 | tri 12 | 64.0 | 50.7 | + | – | – | – |
35 | 60 | M | 4 | T | 5.0 | V3–53, D3–22, J5 | tri 12 | 80.0 | 48.0 | + | – | + | + |
36 | 79 | F | 1 | NT | 3.7 | V4–34, D2–8, J2 | Normal | 67.0 | 89.0 | – | + | – | + |
37 | 69 | M | 1 | NT | 10.0 | V3–23, D3–22, J5 | tri 12 | 84.6 | 38.6 | + | – | – | + |
38 | 61 | M | 2 | NT | 7.0 | V3–21, D2–2, J5 | tri 12, del 13 | 49.1 | 24.8 | – | – | – | – |
39 | 70 | F | 9 | NT | 5.0 | V5–51, D6–19, J4 | Normal | 95.2 | 41.5 | + | + | – | + |
40 | 62 | M | 5 | T | 3.0 | V7–4-1, D6–19, J3 | ND | 79.0 | 10.6 | – | + | + | + |
41 | 71 | F | 1 | NT | 1.0 | V1–69 | Normal | 7.7 | 44.3 | – | + | – | + |
42 | 65 | F | 5 | NT | 0.8 | V1–69, D3–3, J6 | Normal | 8.5 | 31.6 | – | – | – | + |
43 | 69 | M | 5 | NT | 3.0 | V3–30, D2–28, J4 | ND | 15.0 | 14.9 | – | – | – | + |
44 | 70 | F | 5 | CHL | 0.0 | V1–69 | del 11, 13 | 25.0 | 5.7 | + | – | + | + |
45 | 73 | F | 4 | T | 0.0 | V3–30, D4–17, J6 | ND | 91.0 | 0.4 | – | – | – | + |
46 | 68 | F | 9 | T | 0.0 | V3–30 | del 11, 13 | 54.0 | 1.6 | + | – | + | + |
47 | 76 | M | 1 | T | 7.7 | V2–70, D5–24, J4 | tri 12, del 13 | 49.7 | 2.4 | + | – | – | – |
48 | 66 | M | 9 | CHL | 8.8 | V3–33, D3–9, J5 | Normal | 75.5 | 0.2 | – | – | + | + |
49 | 68 | M | 11 | T | 7.1 | V3–11, D3–16, J6 | tri 12 | 33.0 | 0.2 | + | + | – | + |
50 | 66 | M | 2 | NT | 9.5 | V3–48 | Normal | 54.2 | 0.8 | – | – | – | + |
51 | 75 | M | 5 | CHL | 3.6 | V6–1, D4–23, J6 | del 13, 17 | 81.8 | 8.9 | + | + | – | + |
52 | 71 | M | 12 | NT | 4.1 | V3–7, D3–16, J4 | ND | 88.0 | 1.3 | – | – | + | – |
53 | 59 | M | 7 | T | ND | ND | Normal | 87.0 | 2.7 | + | + | – | – |
54 | 69 | M | 1 | NT | 5.4 | V3–7, D6–13, J6 | ND | 61.0 | 0.8 | – | – | – | + |
55 | 77 | F | 5 | NT | ND | ND | tri 12, del 17 | 70.0 | 11.50 | – | – | + | – |
56 | 79 | F | 4 | NT | 1 | V1–18, D4–17, J6 | ND | 42.0 | 0.50 | – | – | + | – |
ID no. . | Age, y . | Sex . | Years from diagnosis . | Therapy . | IgV mutations, % . | VH usage . | FISH . | CD38, % . | ZAP-70, % . | Sig . | IL-2 . | Arr . | Mig . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 68 | M | 1 | NT | 10.5 | V3–72, D1–20, J6 | Normal | 1.0 | 0.7 | – | – | – | + |
2 | 55 | F | 4 | NT | 5.7 | V3–72, D3–22, J4 | del 13 | 1.3 | 0.2 | – | – | – | + |
3 | 67 | F | 19 | CHL | 3.7 | V1–2, D4–17, J3 | del 13 | 1.5 | 9.0 | + | + | + | + |
4 | 77 | M | 11 | NT | 4.8 | V3–11, D6–6, J4 | del 13, 17 | 2.0 | 0.0 | – | + | – | + |
5 | 69 | M | 5 | NT | 5.4 | V3–7, D2–8, J4 | Normal | 2.0 | 0.3 | – | + | + | + |
6 | 70 | F | 6 | NT | 6.1 | V3–30, D2–2, J4 | Normal | 2.0 | 6.2 | – | – | – | + |
7 | 61 | F | 9 | CHL | 8.1 | V1–2 | del 13 | 2.0 | 4.5 | + | – | + | – |
8 | 47 | M | 7 | T | 6.8 | V4–61, D3–10, J4 | ND | 2.0 | 0.1 | – | – | – | + |
9 | 69 | F | 7 | NT | 10.2 | V3–23, D3–10, J4 | del 13 | 3.0 | 1.0 | – | + | – | + |
10 | 73 | F | 7 | CHL | 9.5 | V3–30, J5 | del 13 | 5.2 | 0.2 | – | – | – | + |
11 | 64 | F | UN | UN | 6.3 | V3–30 | del 13 | 6.5 | 0.7 | – | – | + | + |
12 | 68 | F | 1 | NT | 3.8 | V3–13, J5 | del 13 | 6.7 | 0.9 | – | + | – | – |
13 | 70 | F | 8 | NT | 5.4 | V3–30 | del 13 | 10.4 | 0.8 | – | – | – | + |
14 | 64 | F | 6 | NT | ND | ND | Normal | 12.0 | 0.3 | – | – | – | + |
15 | 65 | F | 12 | T | 8.0 | V3–23, J5 | del 13 | 12.9 | 0.1 | – | + | – | + |
16 | 63 | M | 6 | NT | 5.1 | V4–34 | Normal | 13.0 | 1.0 | + | – | – | – |
17 | 75 | M | 4 | NT | 7.8 | V3–11, D3–10, J4 | ND | 15.0 | 2.4 | – | – | – | + |
18 | 74 | F | 5 | CHL | 3.7 | V1–3 | del 17 | 18.0 | 0.8 | + | – | – | – |
19 | 71 | F | 14 | CHL | 10.4 | V3–9, D2–2, J4 | del 17 | 1.9 | 1.7 | – | – | + | + |
20 | 54 | F | 2 | NT | 2.4 | V3–74, D3–10, J4 | Normal | 10.0 | 5.0 | – | – | + | + |
21 | 78 | M | 11 | NT | 1.0 | V1–69, D4–17, J4 | tri 12 | 21.0 | 14.3 | + | + | + | + |
22 | 54 | M | 6 | T | 0.9 | V3–13, D3–22, J5b | del 13 | 24.5 | 35.4 | + | – | + | + |
23 | 80 | M | 4 | T | 0.0 | V1–2 | del 13, 17 | 52.6 | 12.0 | + | + | + | + |
24 | 72 | F | 8 | T | 0.0 | V3–11, D3–10, J5 | Normal | 56.0 | 21.4 | + | – | + | + |
25 | 51 | M | 4 | T | 0.3 | V1–69, D5–5, J6 | ND | 36.0 | 10.6 | + | + | – | + |
26 | 60 | M | 2 | T | 0.7 | V3–74, D7–27, J4 | del 13 | 45.0 | 35.4 | – | – | – | + |
27 | 67 | M | 6 | NT | 0.7 | V4–59 | Normal | 78.5 | 20.3 | + | – | + | – |
28 | 74 | F | 10 | T | 1.0 | V3–48 | Normal | 68.0 | 82.0 | + | – | – | + |
29 | 78 | M | 3 | T | 1.4 | V3–48 | Normal | 70.0 | 34.2 | – | + | – | + |
30 | 86 | M | 3 | T | 0.3 | V1–69, D2–15, J6 | ND | 66.0 | 20.0 | + | + | + | + |
31 | 70 | F | 11 | T | 1.0 | V1–69, D3–16, J6 | tri 12 | 90.0 | 34.4 | – | – | – | – |
32 | 62 | M | 2 | NT | 0.3 | V3–11, D3–22, J4 | del 11 | 98.0 | 17.0 | – | – | – | + |
33 | 83 | M | 2 | NT | 3.0 | V3–30, D2–8 | tri 12 | 74.0 | 51.0 | – | + | – | + |
34 | 64 | M | 4 | NT | 5.8 | V3–74, D1–26, J5 | tri 12 | 64.0 | 50.7 | + | – | – | – |
35 | 60 | M | 4 | T | 5.0 | V3–53, D3–22, J5 | tri 12 | 80.0 | 48.0 | + | – | + | + |
36 | 79 | F | 1 | NT | 3.7 | V4–34, D2–8, J2 | Normal | 67.0 | 89.0 | – | + | – | + |
37 | 69 | M | 1 | NT | 10.0 | V3–23, D3–22, J5 | tri 12 | 84.6 | 38.6 | + | – | – | + |
38 | 61 | M | 2 | NT | 7.0 | V3–21, D2–2, J5 | tri 12, del 13 | 49.1 | 24.8 | – | – | – | – |
39 | 70 | F | 9 | NT | 5.0 | V5–51, D6–19, J4 | Normal | 95.2 | 41.5 | + | + | – | + |
40 | 62 | M | 5 | T | 3.0 | V7–4-1, D6–19, J3 | ND | 79.0 | 10.6 | – | + | + | + |
41 | 71 | F | 1 | NT | 1.0 | V1–69 | Normal | 7.7 | 44.3 | – | + | – | + |
42 | 65 | F | 5 | NT | 0.8 | V1–69, D3–3, J6 | Normal | 8.5 | 31.6 | – | – | – | + |
43 | 69 | M | 5 | NT | 3.0 | V3–30, D2–28, J4 | ND | 15.0 | 14.9 | – | – | – | + |
44 | 70 | F | 5 | CHL | 0.0 | V1–69 | del 11, 13 | 25.0 | 5.7 | + | – | + | + |
45 | 73 | F | 4 | T | 0.0 | V3–30, D4–17, J6 | ND | 91.0 | 0.4 | – | – | – | + |
46 | 68 | F | 9 | T | 0.0 | V3–30 | del 11, 13 | 54.0 | 1.6 | + | – | + | + |
47 | 76 | M | 1 | T | 7.7 | V2–70, D5–24, J4 | tri 12, del 13 | 49.7 | 2.4 | + | – | – | – |
48 | 66 | M | 9 | CHL | 8.8 | V3–33, D3–9, J5 | Normal | 75.5 | 0.2 | – | – | + | + |
49 | 68 | M | 11 | T | 7.1 | V3–11, D3–16, J6 | tri 12 | 33.0 | 0.2 | + | + | – | + |
50 | 66 | M | 2 | NT | 9.5 | V3–48 | Normal | 54.2 | 0.8 | – | – | – | + |
51 | 75 | M | 5 | CHL | 3.6 | V6–1, D4–23, J6 | del 13, 17 | 81.8 | 8.9 | + | + | – | + |
52 | 71 | M | 12 | NT | 4.1 | V3–7, D3–16, J4 | ND | 88.0 | 1.3 | – | – | + | – |
53 | 59 | M | 7 | T | ND | ND | Normal | 87.0 | 2.7 | + | + | – | – |
54 | 69 | M | 1 | NT | 5.4 | V3–7, D6–13, J6 | ND | 61.0 | 0.8 | – | – | – | + |
55 | 77 | F | 5 | NT | ND | ND | tri 12, del 17 | 70.0 | 11.50 | – | – | + | – |
56 | 79 | F | 4 | NT | 1 | V1–18, D4–17, J6 | ND | 42.0 | 0.50 | – | – | + | – |
Sig indicates signal transduction; Arr, microarray; Mig, migration; NT, not treated; CHL, chlorambucil; T, treated; ND, not determined; UN, unknown; del, deletion; tri, trisomy; and –, not done.