Mean hepcidin values before and after iron challenge in different study groups
| . | Baseline hepcidin (ng/mg creatinine) . | 24-hour hepcidin (ng/mg creatinine) . | P . |
|---|---|---|---|
| Controls (n=23) | 36.44 (24.3-54.7) | 86.9 (58.2-129.8) | .001 |
| Cases (n=96) | 18 (13.87-23.38) | 18.3 (14.33-23.4) | NS |
| C282Y/C282Y (n=65) | 13.95 (10.6-18.3) | 13.99 (10.8-18.1) | NS |
| C282Y/H63D (n=31) | 30.8 (17.7-53.6) | 32.2 (19.5-53.1) | NS |
| Group A C282Y/C282Y (n=19) | 27.8 (15.2-50.7) | 24.9 (14.5-42.7) | NS |
| Group A C282Y/H63D (n=15) | 83.4 (42.6-163.2) | 61.4 (31.5-119.6) | NS |
| Group B C282Y/C282Y (n=46) | 10.5 (8.1-13.6) | 11. (8.4-14.4) | NS |
| Group B C282Y/H63D (n=16) | 12.1 (6.6-22) | 17.6 (9.05-34.2) | NS |
| Group A (n=34) | 45.1 (28.3-71.9) | 37 (24.1-56.9) | NS |
| Group B (n=62) | 10.9 (8.6-13.8) | 12.4 (9.6-16.1) | NS |
| . | Baseline hepcidin (ng/mg creatinine) . | 24-hour hepcidin (ng/mg creatinine) . | P . |
|---|---|---|---|
| Controls (n=23) | 36.44 (24.3-54.7) | 86.9 (58.2-129.8) | .001 |
| Cases (n=96) | 18 (13.87-23.38) | 18.3 (14.33-23.4) | NS |
| C282Y/C282Y (n=65) | 13.95 (10.6-18.3) | 13.99 (10.8-18.1) | NS |
| C282Y/H63D (n=31) | 30.8 (17.7-53.6) | 32.2 (19.5-53.1) | NS |
| Group A C282Y/C282Y (n=19) | 27.8 (15.2-50.7) | 24.9 (14.5-42.7) | NS |
| Group A C282Y/H63D (n=15) | 83.4 (42.6-163.2) | 61.4 (31.5-119.6) | NS |
| Group B C282Y/C282Y (n=46) | 10.5 (8.1-13.6) | 11. (8.4-14.4) | NS |
| Group B C282Y/H63D (n=16) | 12.1 (6.6-22) | 17.6 (9.05-34.2) | NS |
| Group A (n=34) | 45.1 (28.3-71.9) | 37 (24.1-56.9) | NS |
| Group B (n=62) | 10.9 (8.6-13.8) | 12.4 (9.6-16.1) | NS |
Data are geometric means with 95% CI by paired t test.
NS indicates nonsignificant.