ISCL/EORTC proposal on TNM classification of cutaneous lymphoma other than MF/SS
| Classification . |
|---|
| T |
| T1: Solitary skin involvement |
| T1a: a solitary lesion <5 cm diameter |
| T1b: a solitary >5 cm diameter |
| T2: Regional skin involvement: multiple lesions limited to 1 body region or 2 contiguous body regions* |
| T2a: all-disease-encompassing in a <15-cm-diameter circular area |
| T2b: all-disease-encompassing in a >15- and <30-cm-diameter circular area |
| T2c: all-disease-encompassing in a >30-cm-diameter circular area |
| T3: Generalized skin involvement |
| T3a: multiple lesions involving 2 noncontiguous body regions |
| T3b: multiple lesions involving ≥3 body regions |
| N |
| N0: No clinical or pathologic lymph node involvement |
| N1: Involvement of 1 peripheral lymph node region that drains an area of current or prior skin involvement |
| N2: Involvement of 2 or more peripheral lymph node regions or involvement of any lymph node region† that does not drain an area of current or prior skin involvement |
| N3: Involvement of central lymph nodes |
| M |
| M0: No evidence of extracutaneous non–lymph node disease |
| M1: Extracutaneous non–lymph node disease present |
| Classification . |
|---|
| T |
| T1: Solitary skin involvement |
| T1a: a solitary lesion <5 cm diameter |
| T1b: a solitary >5 cm diameter |
| T2: Regional skin involvement: multiple lesions limited to 1 body region or 2 contiguous body regions* |
| T2a: all-disease-encompassing in a <15-cm-diameter circular area |
| T2b: all-disease-encompassing in a >15- and <30-cm-diameter circular area |
| T2c: all-disease-encompassing in a >30-cm-diameter circular area |
| T3: Generalized skin involvement |
| T3a: multiple lesions involving 2 noncontiguous body regions |
| T3b: multiple lesions involving ≥3 body regions |
| N |
| N0: No clinical or pathologic lymph node involvement |
| N1: Involvement of 1 peripheral lymph node region that drains an area of current or prior skin involvement |
| N2: Involvement of 2 or more peripheral lymph node regions or involvement of any lymph node region† that does not drain an area of current or prior skin involvement |
| N3: Involvement of central lymph nodes |
| M |
| M0: No evidence of extracutaneous non–lymph node disease |
| M1: Extracutaneous non–lymph node disease present |
Definition of body regions (see Figure 1): Head and neck: inferior border—superior border of clavicles, T1 spinous process. Chest: superior border—superior border of clavicles; inferior border—inferior margin of rib cage; lateral borders—mid-axillary lines, glenohumeral joints (inclusive of axillae). Abdomen/genital: superior border—inferior margin of rib cage; inferior border—inguinal folds, anterior perineum; lateral borders—mid-axillary lines. Upper back: superior border—T1 spinous process; inferior border—inferior margin of rib cage; lateral borders—mid-axillary lines. Lower back/buttocks: superior border—inferior margin of rib cage; inferior border—inferior gluteal fold, anterior perineum (inclusive of perineum); lateral borders—mid-axillary lines. Each upper arm: superior borders—glenohumeral joints (exclusive of axillae); inferior borders—ulnar/radial-humeral (elbow) joint. Each lower arm/hand: superior borders—ulnar/radial-humeral (elbow) joint. Each upper leg (thigh): superior borders—inguinal folds, inferior gluteal folds; inferior borders—mid-patellae, mid-popliteal fossae. Each lower leg/foot: superior borders—mid-patellae, mid-popliteal fossae.
Definition of lymph node regions is consistent with the Ann Arbor system: Peripheral sites: antecubital, cervical, supraclavicular, axillary, inguinal-femoral, and popliteal. Central sites: mediastinal, pulmonary hilar, paraortic, iliac.