Table 1 Association of NPM-ALK PCR... | American Society of Hematology

Table 1

Association of NPM-ALK PCR results in bone marrow with clinical risk factors and immunophenotype of the ALCL

	All patients	BM PCR patients, (%)		P
	All patients	Negative	Positive	P
All patients	80	42 (53)	38 (47)
Skin				.999
No	66	35 (53)	31 (47)
Yes	14	7 (50)	7 (50)
Mediastinum				.002
No	41	29 (71)	12 (29)
Yes	39	13 (33)	26 (67)
Visceral organs*				.01
No	59	36 (61)	23 (39)
Yes	21	6 (29)	15 (71)
CNS				.34
No	76	41 (54)	35 (46)
Yes	4	1 (25)	3 (75)
BM				.002
Neg	72	42 (58)	30 (42)
Pos	8	0	8 (100)
Stage†				.001
I	8	8 (100)	0 (0)
II	14	12 (86)	2 (14)
III	48	21 (44)	27 (56)
IV	10‡	1 (10)	9‡ (90)
Histologic subtype				.005
Common	39	28 (72)	11 (18)
sc, lh, mixed, giant, nfc	36	14 (39)	22 (61)
na	5	0	5
CD3				.26
Neg	46	27 (59)	19 (41)
Pos	31	14 (45)	17 (55)
na	3	1 (33)	2 (67)

	All patients	BM PCR patients, (%)		P
	All patients	Negative	Positive	P
All patients	80	42 (53)	38 (47)
Skin				.999
No	66	35 (53)	31 (47)
Yes	14	7 (50)	7 (50)
Mediastinum				.002
No	41	29 (71)	12 (29)
Yes	39	13 (33)	26 (67)
Visceral organs*				.01
No	59	36 (61)	23 (39)
Yes	21	6 (29)	15 (71)
CNS				.34
No	76	41 (54)	35 (46)
Yes	4	1 (25)	3 (75)
BM				.002
Neg	72	42 (58)	30 (42)
Pos	8	0	8 (100)
Stage†				.001
I	8	8 (100)	0 (0)
II	14	12 (86)	2 (14)
III	48	21 (44)	27 (56)
IV	10‡	1 (10)	9‡ (90)
Histologic subtype				.005
Common	39	28 (72)	11 (18)
sc, lh, mixed, giant, nfc	36	14 (39)	22 (61)
na	5	0	5
CD3				.26
Neg	46	27 (59)	19 (41)
Pos	31	14 (45)	17 (55)
na	3	1 (33)	2 (67)

BM indicates bone marrow; CNS, central nervous system; na, not available; sc, small cell, lh, lymphohistiocytic, and nfc, not further classified.

Liver, spleen, lung.

St Jude's staging system.

Two patients had involvement of both BM and CNS.