Laboratory parameters and TCD flow velocities for 37 children with SCA, before hydroxyurea therapy and after reaching MTD
| . | Before hydroxyurea . | Hydroxyurea at MTD . | P . | ||
|---|---|---|---|---|---|
| Mean ± 1 SD . | Median . | Mean ± 1 SD . | Median . | ||
| Age, y | 6.8 ± 3.5 | 5.6 | 7.6 ± 3.2 | 6.8 | NA |
| Hb, g/dL | 7.8 ± 1.1 | 7.8 | 9.4 ± 1.0 | 9.4 | < .001 |
| Hematocrit, % | 22.5 ± 3.3 | 22.0 | 26.8 ± 3.0 | 26.5 | < .001 |
| MCV, fL | 86 ± 8 | 88 | 104 ± 9 | 103 | < .001 |
| HbF, % | 10.3 ± 6.6 | 9.9 | 22.7 ± 7.9 | 23.3 | < .001 |
| R MCA, cm/s | 166 ± 27 | 162 | 135 ± 27 | 134 | < .001 |
| L MCA, cm/s | 168 ± 26 | 166 | 142 ± 27 | 144 | < .001 |
| R ACA, cm/s | 130 ± 25 | 127 | 110 ± 33 | 98 | .006 |
| L ACA, cm/s | 132 ± 29 | 133 | 113 ± 29 | 114 | .008 |
| R PCA, cm/s | 85 ± 30 | 87 | 76 ± 23 | 78 | NS |
| L PCA, cm/s | 91 ± 29 | 90 | 73 ± 24 | 77 | .006 |
| . | Before hydroxyurea . | Hydroxyurea at MTD . | P . | ||
|---|---|---|---|---|---|
| Mean ± 1 SD . | Median . | Mean ± 1 SD . | Median . | ||
| Age, y | 6.8 ± 3.5 | 5.6 | 7.6 ± 3.2 | 6.8 | NA |
| Hb, g/dL | 7.8 ± 1.1 | 7.8 | 9.4 ± 1.0 | 9.4 | < .001 |
| Hematocrit, % | 22.5 ± 3.3 | 22.0 | 26.8 ± 3.0 | 26.5 | < .001 |
| MCV, fL | 86 ± 8 | 88 | 104 ± 9 | 103 | < .001 |
| HbF, % | 10.3 ± 6.6 | 9.9 | 22.7 ± 7.9 | 23.3 | < .001 |
| R MCA, cm/s | 166 ± 27 | 162 | 135 ± 27 | 134 | < .001 |
| L MCA, cm/s | 168 ± 26 | 166 | 142 ± 27 | 144 | < .001 |
| R ACA, cm/s | 130 ± 25 | 127 | 110 ± 33 | 98 | .006 |
| L ACA, cm/s | 132 ± 29 | 133 | 113 ± 29 | 114 | .008 |
| R PCA, cm/s | 85 ± 30 | 87 | 76 ± 23 | 78 | NS |
| L PCA, cm/s | 91 ± 29 | 90 | 73 ± 24 | 77 | .006 |
NA indicates not applicable; NS, not significant.