Rearrangements detected at diagnosis and relapse in cohort B patients
| Patient ID and marker . | Rearrangement detected . | ||
|---|---|---|---|
| Diagnosis only . | Relapse only . | Both diagnosis and relapse . | |
| B-lineage ALL | |||
| B1 | |||
| Ig | — | VκInt/κdel | Vκ3–20/κdel |
| TCR | Vγ9/Jγ2* | — | Vγ3/Jγ2, Vγ9/Jγ2 |
| B3 | |||
| Ig | — | — | VH3–30/D2–21/J4; Vκ1–8/κdel |
| TCR | — | — | Vγ2/Jγ2, Vγ3/Jγ2 |
| B6 | |||
| Ig | — | VH4–39/D5–5/J4† | VH3–33/D5–5/J4 |
| TCR | — | — | Vγ2/Jγ1 |
| B7 | |||
| Ig | VH6–1/D6–13/J1 | VH6–1/D6–13/J2† | Vκ4–1/κdel |
| TCR | Vδ2/Dδ3 | — | — |
| B8 | |||
| Ig | VH3–13/D1–7/D1–26/J6 | VκInt/κdel | — |
| TCR | — | — | Vγ3/Jγ2 |
| B10 | |||
| Ig | VH2–5/D1–26/J4 | — | VH3–33/D2–2/J5 |
| TCR | Vδ2/Dδ3, Dδ2/Dδ3 | — | — |
| B11 | |||
| Ig | — | — | VH1–2/D2–2/J4; VH4–59/D2–2/J6 |
| TCR | Vγ9/Jγ2 | — | Vδ2/Dδ3 |
| B12 | |||
| Ig | VH3–13/D2–8/J5; DH2–8/J5 | — | |
| B13 | |||
| Ig | VH3–33/D3–16/D2–27/J3; Vκ1–5/κdel | — | Vκ3–20/κdel |
| TCR | — | — | Vγ2/Jγ1, Vγ3/Jγ1; Vδ2/Dδ3 |
| B14 | |||
| Ig | DH3–9/J3 | — | DH5–12/J4 |
| TCR | Vδ2/Dδ3 | Vγ4Jγ1, Vγ11/Jγ1† | — |
| B15 | |||
| TCR | — | — | Vγ11/Jγ1 |
| B16 | |||
| Ig | — | Vκ1–8/κdel, Vκ7–3/κdel† | VH3–30/D6–13/J6 |
| TCR | Vδ2/Jδ1 | — | — |
| B17 | |||
| Ig | VH1–46/D2–15/J5 | — | VH3–48/D2–15/J5; VH6–1/D3–10/J1; VκInt/κdel |
| TCR | Vγ11/Jγ1* | — | Vγ11/Jγ1; Vδ2/Dδ3 |
| B18 | |||
| Ig | — | — | VH1–3/D6–13/J6 |
| TCR | — | — | Vδ2/Dδ3 |
| B19 | |||
| Ig | VH5–51/D3–3/J4 | VH6–1/D2–8/J6† | DH2–8/J6; VH3–30/D6–6/J4 |
| TCR | — | Vγ11/Jγ2; Vδ2/Dδ3, Dδ2/Dδ3 | — |
| B20 | |||
| Ig | VH2–26/J6 | VH3–23/D6–6/J5† | Vκ7–3 |
| TCR | — | — | Vγ4/Jγ2 |
| B21 | |||
| Ig | — | — | VH1–2/D3–3/J6 |
| B22 | |||
| Ig | VH3–13/D2–8/JH1 | — | VH6–1/D6–25/J4; Vκ1/κdel |
| TCR | — | — | Vγ4/Jγ1, Vγ11/Jγ1; Dδ2/Dδ3, Vδ2/Dδ3 |
| T-cell ALL | |||
| B2 | |||
| TCR | — | — | Vγ2/Jγ2‡, Vγ3/Jγ2‡; Vδ1/Jδ1‡ |
| B4 | |||
| TCR | — | — | Vγ2/Jγ1, Vγ3/Jγ2; Vδ2/Jδ1, Vδ2/Dδ3, Dδ2/Jδ1 |
| B5 | |||
| Ig | DH4–23/J4 | — | — |
| TCR | Vγ3/Jγ2, Vγ9/Jγ1, Vγ10/Jγ2; Vδ2/Dδ3 | — | Vγ9/Jγ2 |
| B9 | |||
| Ig | DH4–23/J4 | — | — |
| TCR | — | — | Vγ2/Jγ2 |
| Totals | 26 | 13 | 50 |
| Patient ID and marker . | Rearrangement detected . | ||
|---|---|---|---|
| Diagnosis only . | Relapse only . | Both diagnosis and relapse . | |
| B-lineage ALL | |||
| B1 | |||
| Ig | — | VκInt/κdel | Vκ3–20/κdel |
| TCR | Vγ9/Jγ2* | — | Vγ3/Jγ2, Vγ9/Jγ2 |
| B3 | |||
| Ig | — | — | VH3–30/D2–21/J4; Vκ1–8/κdel |
| TCR | — | — | Vγ2/Jγ2, Vγ3/Jγ2 |
| B6 | |||
| Ig | — | VH4–39/D5–5/J4† | VH3–33/D5–5/J4 |
| TCR | — | — | Vγ2/Jγ1 |
| B7 | |||
| Ig | VH6–1/D6–13/J1 | VH6–1/D6–13/J2† | Vκ4–1/κdel |
| TCR | Vδ2/Dδ3 | — | — |
| B8 | |||
| Ig | VH3–13/D1–7/D1–26/J6 | VκInt/κdel | — |
| TCR | — | — | Vγ3/Jγ2 |
| B10 | |||
| Ig | VH2–5/D1–26/J4 | — | VH3–33/D2–2/J5 |
| TCR | Vδ2/Dδ3, Dδ2/Dδ3 | — | — |
| B11 | |||
| Ig | — | — | VH1–2/D2–2/J4; VH4–59/D2–2/J6 |
| TCR | Vγ9/Jγ2 | — | Vδ2/Dδ3 |
| B12 | |||
| Ig | VH3–13/D2–8/J5; DH2–8/J5 | — | |
| B13 | |||
| Ig | VH3–33/D3–16/D2–27/J3; Vκ1–5/κdel | — | Vκ3–20/κdel |
| TCR | — | — | Vγ2/Jγ1, Vγ3/Jγ1; Vδ2/Dδ3 |
| B14 | |||
| Ig | DH3–9/J3 | — | DH5–12/J4 |
| TCR | Vδ2/Dδ3 | Vγ4Jγ1, Vγ11/Jγ1† | — |
| B15 | |||
| TCR | — | — | Vγ11/Jγ1 |
| B16 | |||
| Ig | — | Vκ1–8/κdel, Vκ7–3/κdel† | VH3–30/D6–13/J6 |
| TCR | Vδ2/Jδ1 | — | — |
| B17 | |||
| Ig | VH1–46/D2–15/J5 | — | VH3–48/D2–15/J5; VH6–1/D3–10/J1; VκInt/κdel |
| TCR | Vγ11/Jγ1* | — | Vγ11/Jγ1; Vδ2/Dδ3 |
| B18 | |||
| Ig | — | — | VH1–3/D6–13/J6 |
| TCR | — | — | Vδ2/Dδ3 |
| B19 | |||
| Ig | VH5–51/D3–3/J4 | VH6–1/D2–8/J6† | DH2–8/J6; VH3–30/D6–6/J4 |
| TCR | — | Vγ11/Jγ2; Vδ2/Dδ3, Dδ2/Dδ3 | — |
| B20 | |||
| Ig | VH2–26/J6 | VH3–23/D6–6/J5† | Vκ7–3 |
| TCR | — | — | Vγ4/Jγ2 |
| B21 | |||
| Ig | — | — | VH1–2/D3–3/J6 |
| B22 | |||
| Ig | VH3–13/D2–8/JH1 | — | VH6–1/D6–25/J4; Vκ1/κdel |
| TCR | — | — | Vγ4/Jγ1, Vγ11/Jγ1; Dδ2/Dδ3, Vδ2/Dδ3 |
| T-cell ALL | |||
| B2 | |||
| TCR | — | — | Vγ2/Jγ2‡, Vγ3/Jγ2‡; Vδ1/Jδ1‡ |
| B4 | |||
| TCR | — | — | Vγ2/Jγ1, Vγ3/Jγ2; Vδ2/Jδ1, Vδ2/Dδ3, Dδ2/Jδ1 |
| B5 | |||
| Ig | DH4–23/J4 | — | — |
| TCR | Vγ3/Jγ2, Vγ9/Jγ1, Vγ10/Jγ2; Vδ2/Dδ3 | — | Vγ9/Jγ2 |
| B9 | |||
| Ig | DH4–23/J4 | — | — |
| TCR | — | — | Vγ2/Jγ2 |
| Totals | 26 | 13 | 50 |