Incorporation of lymphoid neoplasm subtypes defined by the Working Formulation into the proposed WHO-based nested classification of malignant lymphoid neoplasms, with basic immunophenotype data (ie, B-cell versus T-cell)
| Working Formulation categories . | Hierarchical group . | |||||
|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | |
| A. Small lymphocytic, B-cell | LN | NHL | B-NHL | Mature B-NHL | — | — |
| A. Small lymphocytic, T-cell | LN | NHL | T-NHL | Mature T-NHL | — | — |
| A. Small lymphocytic, unknown cell | LN | NHL | — | — | — | — |
| B. Follicular, small cleaved cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| B. Follicular, small cleaved cell, unknown cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| C. Follicular, mixed small cleaved and large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| C. Follicular, mixed small cleaved and large cell, unknown cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| D. Follicular, large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| D. Follicular, large cell, unknown cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| E. Diffuse, small cleaved cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | — | — |
| E. Diffuse, small cleaved cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | — | — |
| E. Diffuse, small cleaved cell, unknown cell | LN | NHL | — | — | — | — |
| F. Diffuse, mixed small and large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | — | — |
| F. Diffuse, mixed small and large cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| F. Diffuse, mixed small and large cell, unknown cell | LN | NHL | — | — | — | — |
| G. Diffuse, large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | DLBCL | — |
| G. Diffuse, large cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| G. Diffuse, large cell, unknown cell | LN | NHL | — | — | — | — |
| H. Large cell, immunoblastic, B-cell | LN | NHL | B-NHL | Mature B-NHL | DLBCL | — |
| H. Large cell, immunoblastic, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| H. Large cell, immunoblastic, unknown cell | LN | NHL | — | — | — | — |
| I. Lymphoblastic, B-cell | LN | NHL | — | Precursor | Precursor B-NHL | — |
| I. Lymphoblastic, T-cell | LN | NHL | — | Precursor | Precursor T-NHL | — |
| I. Lymphoblastic, unknown cell | LN | NHL | — | Precursor | — | — |
| J. Small noncleaved cell, B-cell* | LN | NHL | B-NHL | Mature B-NHL | BL | — |
| J. Small noncleaved cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| J. Small noncleaved cell, unknown cell | LN | NHL | — | — | — | — |
| K. Unclassified, B-cell | LN | NHL | B-NHL | — | — | — |
| K. Unclassified, T-cell | LN | NHL | T-NHL | — | — | — |
| K. Unclassified, unknown cell | LN | NHL | — | — | — | — |
| Working Formulation categories . | Hierarchical group . | |||||
|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | |
| A. Small lymphocytic, B-cell | LN | NHL | B-NHL | Mature B-NHL | — | — |
| A. Small lymphocytic, T-cell | LN | NHL | T-NHL | Mature T-NHL | — | — |
| A. Small lymphocytic, unknown cell | LN | NHL | — | — | — | — |
| B. Follicular, small cleaved cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| B. Follicular, small cleaved cell, unknown cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| C. Follicular, mixed small cleaved and large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| C. Follicular, mixed small cleaved and large cell, unknown cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| D. Follicular, large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| D. Follicular, large cell, unknown cell | LN | NHL | B-NHL | Mature B-NHL | FL | — |
| E. Diffuse, small cleaved cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | — | — |
| E. Diffuse, small cleaved cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | — | — |
| E. Diffuse, small cleaved cell, unknown cell | LN | NHL | — | — | — | — |
| F. Diffuse, mixed small and large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | — | — |
| F. Diffuse, mixed small and large cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| F. Diffuse, mixed small and large cell, unknown cell | LN | NHL | — | — | — | — |
| G. Diffuse, large cell, B-cell | LN | NHL | B-NHL | Mature B-NHL | DLBCL | — |
| G. Diffuse, large cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| G. Diffuse, large cell, unknown cell | LN | NHL | — | — | — | — |
| H. Large cell, immunoblastic, B-cell | LN | NHL | B-NHL | Mature B-NHL | DLBCL | — |
| H. Large cell, immunoblastic, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| H. Large cell, immunoblastic, unknown cell | LN | NHL | — | — | — | — |
| I. Lymphoblastic, B-cell | LN | NHL | — | Precursor | Precursor B-NHL | — |
| I. Lymphoblastic, T-cell | LN | NHL | — | Precursor | Precursor T-NHL | — |
| I. Lymphoblastic, unknown cell | LN | NHL | — | Precursor | — | — |
| J. Small noncleaved cell, B-cell* | LN | NHL | B-NHL | Mature B-NHL | BL | — |
| J. Small noncleaved cell, T-cell | LN | NHL | T-NHL | Mature T-NHL | PTCL | — |
| J. Small noncleaved cell, unknown cell | LN | NHL | — | — | — | — |
| K. Unclassified, B-cell | LN | NHL | B-NHL | — | — | — |
| K. Unclassified, T-cell | LN | NHL | T-NHL | — | — | — |
| K. Unclassified, unknown cell | LN | NHL | — | — | — | — |
Abbreviations are explained in Table 1.
— indicates category cannot be assigned.
Small noncleaved cell lymphoma should be coded as Burkitt lymphoma only if the growth fraction is nearly 100%, CD10+, Bcl2−, and proven or strong presumptive evidence of MYC translocation; otherwise code to DLBCL. Without these data, cases of small noncleaved cell lymphoma cannot be classified beyond mature B-NHL.