Microorganisms responsible for infection-related mortality on protocol therapy
| Microorganism characteristic . | Phase 1 . | Phase 2 . | Phase 3 . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total . | IdaDCTER . | Fludarabine . | ||||||||
| N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | |
| Total no. of infection-related deaths | 24 | 100 | 24 | 100 | 7 | 29 | 17 | 71 | 10 | 100 |
| Gram-positive cocci | 11 | 46 | 15 | 63 | 4 | 57 | 11 | 65 | 4 | 25 |
| Coagulase-negative staphylococci | 5 | 21 | 8 | 33 | 2 | 29 | 6 | 35 | 1 | 6 |
| Staphylococcus aureus | 0 | 0 | 1 | 4 | 0 | 0 | 1 | 6 | 1 | 6 |
| Alpha hemolytic streptococci | 4 | 17 | 4 | 17 | 1 | 14 | 3 | 18 | 1 | 6 |
| Other streptococci | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Enterococcus species | 3 | 13 | 3 | 13 | 2 | 29 | 1 | 6 | 0 | 0 |
| Other Gram-positive cocci | 4 | 17 | 4 | 17 | 2 | 29 | 2 | 12 | 1 | 6 |
| Gram-negative bacilli and cocci | 8 | 33 | 11 | 46 | 5 | 71 | 6 | 35 | 4 | 25 |
| Pseudomonas species | 1 | 4 | 3 | 13 | 0 | 0 | 3 | 18 | 2 | 13 |
| Escherichiae coli | 1 | 4 | 2 | 8 | 2 | 29 | 0 | 0 | 2 | 13 |
| Klebsiella species | 2 | 8 | 4 | 17 | 3 | 43 | 1 | 6 | 1 | 6 |
| Other enterobacteriaceae | 4 | 17 | 1 | 4 | 0 | 0 | 1 | 6 | 0 | 0 |
| Acinetobacter species | 0 | 0 | 1 | 4 | 0 | 0 | 1 | 6 | 0 | 0 |
| Serratia species | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Gram-negative bacilli | 3 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Gram-negative anaerobe | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 |
| Gram-negative cocci, coccobacilli | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Fungus | 11 | 46 | 15 | 63 | 4 | 57 | 11 | 65 | 7 | 44 |
| Candida albicans | 2 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 13 |
| Other Candida species | 6 | 25 | 4 | 17 | 0 | 0 | 4 | 24 | 1 | 6 |
| Aspergillus species | 3 | 13 | 11 | 46 | 4 | 57 | 7 | 41 | 4 | 25 |
| Fusarium species | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mucor | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other fungus | 1 | 4 | 1 | 4 | 0 | 0 | 1 | 6 | 0 | 0 |
| Viruses | 1 | 4 | 2 | 8 | 1 | 14 | 1 | 6 | 2 | 13 |
| Varicella-zoster virus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Herpes simplex virus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 |
| Cytomegalovirus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 |
| Respiratory syncytial virus | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Influenza virus | 0 | 0 | 2 | 8 | 1 | 14 | 1 | 6 | 0 | 0 |
| Other | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Microorganism characteristic . | Phase 1 . | Phase 2 . | Phase 3 . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total . | IdaDCTER . | Fludarabine . | ||||||||
| N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | |
| Total no. of infection-related deaths | 24 | 100 | 24 | 100 | 7 | 29 | 17 | 71 | 10 | 100 |
| Gram-positive cocci | 11 | 46 | 15 | 63 | 4 | 57 | 11 | 65 | 4 | 25 |
| Coagulase-negative staphylococci | 5 | 21 | 8 | 33 | 2 | 29 | 6 | 35 | 1 | 6 |
| Staphylococcus aureus | 0 | 0 | 1 | 4 | 0 | 0 | 1 | 6 | 1 | 6 |
| Alpha hemolytic streptococci | 4 | 17 | 4 | 17 | 1 | 14 | 3 | 18 | 1 | 6 |
| Other streptococci | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Enterococcus species | 3 | 13 | 3 | 13 | 2 | 29 | 1 | 6 | 0 | 0 |
| Other Gram-positive cocci | 4 | 17 | 4 | 17 | 2 | 29 | 2 | 12 | 1 | 6 |
| Gram-negative bacilli and cocci | 8 | 33 | 11 | 46 | 5 | 71 | 6 | 35 | 4 | 25 |
| Pseudomonas species | 1 | 4 | 3 | 13 | 0 | 0 | 3 | 18 | 2 | 13 |
| Escherichiae coli | 1 | 4 | 2 | 8 | 2 | 29 | 0 | 0 | 2 | 13 |
| Klebsiella species | 2 | 8 | 4 | 17 | 3 | 43 | 1 | 6 | 1 | 6 |
| Other enterobacteriaceae | 4 | 17 | 1 | 4 | 0 | 0 | 1 | 6 | 0 | 0 |
| Acinetobacter species | 0 | 0 | 1 | 4 | 0 | 0 | 1 | 6 | 0 | 0 |
| Serratia species | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Gram-negative bacilli | 3 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Gram-negative anaerobe | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 |
| Gram-negative cocci, coccobacilli | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Fungus | 11 | 46 | 15 | 63 | 4 | 57 | 11 | 65 | 7 | 44 |
| Candida albicans | 2 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 13 |
| Other Candida species | 6 | 25 | 4 | 17 | 0 | 0 | 4 | 24 | 1 | 6 |
| Aspergillus species | 3 | 13 | 11 | 46 | 4 | 57 | 7 | 41 | 4 | 25 |
| Fusarium species | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mucor | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other fungus | 1 | 4 | 1 | 4 | 0 | 0 | 1 | 6 | 0 | 0 |
| Viruses | 1 | 4 | 2 | 8 | 1 | 14 | 1 | 6 | 2 | 13 |
| Varicella-zoster virus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Herpes simplex virus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 |
| Cytomegalovirus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6 |
| Respiratory syncytial virus | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Influenza virus | 0 | 0 | 2 | 8 | 1 | 14 | 1 | 6 | 0 | 0 |
| Other | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sum of columns and rows do not match, as some patients had multiple organisms as the cause of death.
IdaDCTER regimen indicates idarubicin, daunomycin, cytarabine, thioguanine, etoposide, and dexamethasone; and fludarabine-based regimen, fludarabine, cytosine arabinoside, and idarubicin.