Univariate regression predicting the risk of microbiologically documented bacterial infection (any site) by phase of treatment
| Characteristic . | Phase 1 . | Phase 2 . | Phase 3 . | |||
|---|---|---|---|---|---|---|
| IRR (95% CI) . | P . | IRR (95% CI) . | P . | IRR (95% CI) . | P . | |
| Rate of infections per day | 0.0220 | 0.0226 | 0.0222 | |||
| Age, y | ||||||
| 0 to younger than 2 | 1.22 (0.97-1.55) | .087 | 1.15 (0.90-1.46) | .255 | 1.22 (0.89-1.68) | .215 |
| 2 to 16 | Ref | NA | Ref | NA | Ref | NA |
| Older than 16 | 1.09 (0.82-1.46) | .563 | 1.10 (0.83-1.45) | .512 | 1.49(1.01-2.20) | .045 |
| Ethnicity | ||||||
| White | Ref | NA | Ref | NA | Ref | NA |
| Not white | 0.99 (0.81-1.22) | .954 | 1.03 (0.84-1.25) | .785 | 1.01(0.78-1.32) | .928 |
| BMI percentile at diagnosis* | ||||||
| Underweight | 0.95 (0.65-1.38) | .773 | 1.05 (0.72-1.53) | .807 | 0.89 (0.44-1.81) | .751 |
| Normal weight | Ref | NA | Ref | NA | Ref | NA |
| Overweight | 1.09 (0.79-1.49) | .603 | 1.54 (1.19-2.00) | <.001 | 0.701(0.45-1.08) | .108 |
| Cytogenetics | ||||||
| Favorable | 0.81 (0.59-1.11) | .198 | 0.85 (0.65-1.10) | .214 | 0.84 (0.59-1.18) | .309 |
| Intermediate | Ref | NA | Ref | NA | Ref | NA |
| Unfavorable | 0.88 (0.57-1.36) | .558 | 0.89 (0.46-1.73) | .728 | 2.07 (0.97-4.42) | .062 |
| Unknown | 0.96 (0.77-1.20) | .738 | 0.86 (0.69-1.06) | .149 | 0.64 (0.47-0.86) | .003 |
| Time to ANC higher than 1000/μL | ||||||
| Median no. days or fewer | 1.11 (0.88-1.39) | .380 | 1.18 (0.95-1.46) | .137 | 0.87 (0.66-1.14) | .314 |
| More than the median no. of days | Ref | NA | Ref | NA | Ref | NA |
| Institution size† | ||||||
| 6 or fewer | 1.04 (0.82-1.34) | .729 | 1.01 (0.80-1.29) | .921 | 1.07 (0.77-1.48) | .694 |
| More than 6 | Ref | NA | Ref | NA | Ref | NA |
| Characteristic . | Phase 1 . | Phase 2 . | Phase 3 . | |||
|---|---|---|---|---|---|---|
| IRR (95% CI) . | P . | IRR (95% CI) . | P . | IRR (95% CI) . | P . | |
| Rate of infections per day | 0.0220 | 0.0226 | 0.0222 | |||
| Age, y | ||||||
| 0 to younger than 2 | 1.22 (0.97-1.55) | .087 | 1.15 (0.90-1.46) | .255 | 1.22 (0.89-1.68) | .215 |
| 2 to 16 | Ref | NA | Ref | NA | Ref | NA |
| Older than 16 | 1.09 (0.82-1.46) | .563 | 1.10 (0.83-1.45) | .512 | 1.49(1.01-2.20) | .045 |
| Ethnicity | ||||||
| White | Ref | NA | Ref | NA | Ref | NA |
| Not white | 0.99 (0.81-1.22) | .954 | 1.03 (0.84-1.25) | .785 | 1.01(0.78-1.32) | .928 |
| BMI percentile at diagnosis* | ||||||
| Underweight | 0.95 (0.65-1.38) | .773 | 1.05 (0.72-1.53) | .807 | 0.89 (0.44-1.81) | .751 |
| Normal weight | Ref | NA | Ref | NA | Ref | NA |
| Overweight | 1.09 (0.79-1.49) | .603 | 1.54 (1.19-2.00) | <.001 | 0.701(0.45-1.08) | .108 |
| Cytogenetics | ||||||
| Favorable | 0.81 (0.59-1.11) | .198 | 0.85 (0.65-1.10) | .214 | 0.84 (0.59-1.18) | .309 |
| Intermediate | Ref | NA | Ref | NA | Ref | NA |
| Unfavorable | 0.88 (0.57-1.36) | .558 | 0.89 (0.46-1.73) | .728 | 2.07 (0.97-4.42) | .062 |
| Unknown | 0.96 (0.77-1.20) | .738 | 0.86 (0.69-1.06) | .149 | 0.64 (0.47-0.86) | .003 |
| Time to ANC higher than 1000/μL | ||||||
| Median no. days or fewer | 1.11 (0.88-1.39) | .380 | 1.18 (0.95-1.46) | .137 | 0.87 (0.66-1.14) | .314 |
| More than the median no. of days | Ref | NA | Ref | NA | Ref | NA |
| Institution size† | ||||||
| 6 or fewer | 1.04 (0.82-1.34) | .729 | 1.01 (0.80-1.29) | .921 | 1.07 (0.77-1.48) | .694 |
| More than 6 | Ref | NA | Ref | NA | Ref | NA |
IRR indicates incidence rate ratio; BMI, body mass index; ANC, absolute neutrophil count; Ref, reference group; and NA, not applicable.
Underweight (≤ 10th percentile); normal weight (between 10th and 95th percentile); and overweight (≥ 95 percentile).
Institution size categorized by median number of enrollments.