Response by baseline BCR-ABL mutation analysis of patients with chronic myeloid leukemia in lymphoid blast crisis
| . | No. patients (%) at 8-mo follow-up . | ||
|---|---|---|---|
| Total . | Patients with MaHR . | Patients with MCyR . | |
| No mutation | 16 (40) | 6/16 (38) | 10/16 (63) |
| Any mutation | 24 (60) | 6/24 (25) | 10/24 (42) |
| P-loop* | 10 (25) | 3/10 (30) | 4/10 (40) |
| Activation loop | 4 (10) | 1/4 (25) | 1/4 (25) |
| Other regions | 10 (25) | 2/10 (20) | 5/10 (50) |
| M244V* | 2 | 1 | 2 |
| G250E* | 2 | 0 | 1 |
| Y253H* | 3 | 1 | 2 |
| E255K* | 4 | 0 | 0 |
| F311I* | 2 | 1 | 2 |
| T315I* | 4 | 0 | 0 |
| V379I* | 2 | 0 | 1 |
| E459K* | 2 | 0 | 1 |
| . | No. patients (%) at 8-mo follow-up . | ||
|---|---|---|---|
| Total . | Patients with MaHR . | Patients with MCyR . | |
| No mutation | 16 (40) | 6/16 (38) | 10/16 (63) |
| Any mutation | 24 (60) | 6/24 (25) | 10/24 (42) |
| P-loop* | 10 (25) | 3/10 (30) | 4/10 (40) |
| Activation loop | 4 (10) | 1/4 (25) | 1/4 (25) |
| Other regions | 10 (25) | 2/10 (20) | 5/10 (50) |
| M244V* | 2 | 1 | 2 |
| G250E* | 2 | 0 | 1 |
| Y253H* | 3 | 1 | 2 |
| E255K* | 4 | 0 | 0 |
| F311I* | 2 | 1 | 2 |
| T315I* | 4 | 0 | 0 |
| V379I* | 2 | 0 | 1 |
| E459K* | 2 | 0 | 1 |
Mutational analysis was not performed at baseline for 2 of 42 patients. P-loop mutations are those in locations 244 through 255.
Activation loop mutations are those in location 379s through 398. N = 40.
Mutations documented in at least 2 patients.