Distribution of engraftment kinetics
| Early repopulation . | Late repopulation . | |||||
|---|---|---|---|---|---|---|
| Increasing (+) . | Constant (π) . | Decreasing (−) . | ||||
| Observed . | Simulated . | Observed . | Simulated . | Observed . | Simulated . | |
| Increasing (+) | 11.5 (5.7; 20.1) | 13.7 | 21.8 (13.7; 32.0) | 22.5 | 19.6 (11.8; 29.4) | 17.2 |
| Constant (π) | 4.6 (1.3; 11.4) | 2.9 | 24.1 (15.6; 34.5) | 17.7 | 6.9 (2.6; 14.4) | 7.3 |
| Decreasing (−) | 0.0 (0; 4.2) | 1.6 | 6.9 (2.6; 14.4) | 10.3 | 4.6 (1.3; 11.4) | 6.8 |
| Early repopulation . | Late repopulation . | |||||
|---|---|---|---|---|---|---|
| Increasing (+) . | Constant (π) . | Decreasing (−) . | ||||
| Observed . | Simulated . | Observed . | Simulated . | Observed . | Simulated . | |
| Increasing (+) | 11.5 (5.7; 20.1) | 13.7 | 21.8 (13.7; 32.0) | 22.5 | 19.6 (11.8; 29.4) | 17.2 |
| Constant (π) | 4.6 (1.3; 11.4) | 2.9 | 24.1 (15.6; 34.5) | 17.7 | 6.9 (2.6; 14.4) | 7.3 |
| Decreasing (−) | 0.0 (0; 4.2) | 1.6 | 6.9 (2.6; 14.4) | 10.3 | 4.6 (1.3; 11.4) | 6.8 |
Given are experimentally observed and simulated frequencies of engraftment kinetics within the 9 classes that are characterized by early (regenerating phase) and late (reconstituted phase) engraftment behavior: decreasing (−), increasing (+), and constant (π) donor contribution. Experimental results are given by class percentage out of 87 successfully engrafted animals (data taken from Sieburg et al18 ) complemented by the corresponding 95% confidence intervals. Simulation results represent class percentages estimated from 9820 individual runs (11 682 total simulations minus 1862 nonengrafting systems). Confidence intervals are negligibly small due to the high number of simulation replicates.