Final Cox regression models for the risk of relapse or death and the risk of death among patients with adult acute lymphoblastic leukemia on MRC UKALLXII/ECOG 2993
| Variable* . | Hazard ratio (95% CI) . | SE . | P . |
|---|---|---|---|
| Risk of relapse or death | |||
| Age | 1.02 (1.01-1.03) | 0.004 | < .001 |
| WCC | 1.20 (1.12-1.28) | 0.04 | < .001 |
| T-cell status | 0.71 (0.56-0.89) | 0.09 | .004 |
| t(8;14)(q24.1;q32) | 2.55 (1.48-4.38) | 0.70 | .001 |
| Low hypodiploidy/near triploidy | 1.90 (1.26-2.86) | 0.40 | .002 |
| Complex karyotype | 1.75 (1.22-2.52) | 0.32 | .002 |
| Risk of death | |||
| Age | 1.03 (1.02-1.03) | 0.004 | < .001 |
| WCC | 1.20 (1.12-1.28) | 0.04 | < .001 |
| T-cell status | 0.75 (0.59-0.96) | 0.09 | .020 |
| Male sex | 0.81 (0.67-0.98) | 0.08 | .027 |
| t(8;14)(q24.1;q32) | 2.73 (1.58-4.72) | 0.76 | < .001 |
| Low hypodiploidy/near triploidy | 1.90 (1.26-2.86) | 0.40 | .002 |
| Complex karyotype | 1.70 (1.17-2.47) | 0.32 | .005 |
| Variable* . | Hazard ratio (95% CI) . | SE . | P . |
|---|---|---|---|
| Risk of relapse or death | |||
| Age | 1.02 (1.01-1.03) | 0.004 | < .001 |
| WCC | 1.20 (1.12-1.28) | 0.04 | < .001 |
| T-cell status | 0.71 (0.56-0.89) | 0.09 | .004 |
| t(8;14)(q24.1;q32) | 2.55 (1.48-4.38) | 0.70 | .001 |
| Low hypodiploidy/near triploidy | 1.90 (1.26-2.86) | 0.40 | .002 |
| Complex karyotype | 1.75 (1.22-2.52) | 0.32 | .002 |
| Risk of death | |||
| Age | 1.03 (1.02-1.03) | 0.004 | < .001 |
| WCC | 1.20 (1.12-1.28) | 0.04 | < .001 |
| T-cell status | 0.75 (0.59-0.96) | 0.09 | .020 |
| Male sex | 0.81 (0.67-0.98) | 0.08 | .027 |
| t(8;14)(q24.1;q32) | 2.73 (1.58-4.72) | 0.76 | < .001 |
| Low hypodiploidy/near triploidy | 1.90 (1.26-2.86) | 0.40 | .002 |
| Complex karyotype | 1.70 (1.17-2.47) | 0.32 | .005 |
All variables were entered to the model as binary categorical variables except age and WCC [log(WCC + 1)], which were used as continuous variables.