Table 2 Distribution and features of... | American Society of Hematology

Table 2

Distribution and features of PAX5, RhoH/TTF, cMYC, and PIM1 mutations in extranodal DLBCL and MALT lymphoma

Locus Entity	Distribution, no. mutated/no. tested (%)		Mutation frequency per 100 bp (range)		Single base pair substitution		G + C/A + T		Transitions over transversions
Locus Entity	DLBCL	MALT	DLBCL	MALT	DLBCL	MALT	DLBCL	MALT	DLBCL	MALT
PAX5	10/17 (58.8)	3/17 (17.6)	0.12* (0.06-0.33)	0.12* (0.11-0.49)	15	5	14:1	4:1	13:2	4:1
RhoH/TTF	8/17 (47.1)	2/17 (11.8)	0.16* (0.07-0.38)	0.09* (0.08-0.10)	11	2	6:5	1:1	7:4	1:1
cMYC	13/17 (76.5)	10/17 (58.8)	0.04* (0.02-0.07)	0.03* (0.02-0.08)	25	12	20:5	11:1	20:5	6:6
PIM1	11/17 (64.7)	8/17 (64.7)	0.14* (0.05-0.38)	0.07* (0.05-0.10)	20	9	18:2	5:4	14:6	3:6
All genes	17/17 (100)	13/17 (76.5)	0.12*	0.08*	71	28	58:13	21:7	54:17	14:14
IgH	—	—	3.98† (2.12-8.16)	1.22† (0.97-5.52)	65	28	51:14	23:5	30:35	17:11

Locus Entity	Distribution, no. mutated/no. tested (%)		Mutation frequency per 100 bp (range)		Single base pair substitution		G + C/A + T		Transitions over transversions
Locus Entity	DLBCL	MALT	DLBCL	MALT	DLBCL	MALT	DLBCL	MALT	DLBCL	MALT
PAX5	10/17 (58.8)	3/17 (17.6)	0.12* (0.06-0.33)	0.12* (0.11-0.49)	15	5	14:1	4:1	13:2	4:1
RhoH/TTF	8/17 (47.1)	2/17 (11.8)	0.16* (0.07-0.38)	0.09* (0.08-0.10)	11	2	6:5	1:1	7:4	1:1
cMYC	13/17 (76.5)	10/17 (58.8)	0.04* (0.02-0.07)	0.03* (0.02-0.08)	25	12	20:5	11:1	20:5	6:6
PIM1	11/17 (64.7)	8/17 (64.7)	0.14* (0.05-0.38)	0.07* (0.05-0.10)	20	9	18:2	5:4	14:6	3:6
All genes	17/17 (100)	13/17 (76.5)	0.12*	0.08*	71	28	58:13	21:7	54:17	14:14
IgH	—	—	3.98† (2.12-8.16)	1.22† (0.97-5.52)	65	28	51:14	23:5	30:35	17:11

— indicates not mutated.

Mutation frequencies were calculated on the entire region analyzed and on mutated cases only, considering 2 alleles/gene/case.

Mutation frequencies for IgH were calculated on the entire region analyzed and on mutated cases only