Table 1 Classification of up- and... | American Society of Hematology

Table 1

Classification of up- and down-regulated genes from Figure 2C, as a function of their biological roles

	Down-regulated genes	Up-regulated genes
Cytoskeleton	SPTA1	MYH9^I, ACTB^I,II, DIAPH1^I, VCL^I, ACTN1^I, WDR1^I, KLHL5^I, CALD1^I, DSTN^I, TJP2^I, DAPP1^I, ZYX^I, STOM^I,II, SDCBP^I, CAPZA2^II, TPM1^II, RAC1^II, PTPN12^II, RAP1B^II, ACTR10^II, ACTR3^II, CKAP5^II
Microtubule dynamic	—	TUBA4^I,II, TUBA1^I, TUBB1^I, TUBA2^II, TUBA6^II
MK and platelet markers	PGDS	SELP^I, PECAM1^I, RAB27B^I, GP1BB^I, PF4V1^I, GP9^I, VWF^I, THBS1^I, ITGB3^I,II, GP1BA^I, STOM^I,II, CD63^II, ITGB1^II, CD36^II, CD226^II, RAP1B^II, CD47^I,II
Platelet adhesion, activation, aggregation, blood coagulation	—	SELP^I, PECAM1^I, GP1BA^I, GP1BB^I, ANXA3^I, F13A1^I, GP9^I, VWF^I, THBS1^I, ITGB3^I,II, CD9^II, CD63^II, CD36^II, SNAP23^II, RAPIB^II, CD47^I,II, PLA2G4A^II
Cell adhesion, migration, and motility	ITGB3BP	ITGA6^I, SELP^I, VCL^I, NID2^I, CCL5^I, CD47^I,II, GP9^I, VWF^I, ZYX^I, ALOX12^I, ITGB3^I,II, GP1BA^I, CD9^II, ITGB1^II, CD36^II, SSX21P^II, CD226^II, ITFG1^II, SDCBP^II, ACTB^I,II, CAPZA2^II, PTPN12^II, ACTR3^II, HMMR^II
Signal transduction	ITGB3BP, ANXA2	ITGA6^I, MYH9^I, CXCL5^I,II, DDEF2^I, LAT^I, MAPRE2^I, RYR2^I, ANXA3^I, NRGN^I, CCL5^I, RAB27B^I, CD47^I,II, RIT1^I, MAPK14^I,II, GRAP2^I, FYN^I, FYB^I, SPSB4^I, EHD3^I, RGS10^I, IRS2^I, ACVR1^I, SPARC^I, DAPP1^I, SDPR^I, ZYX^I, PTG1R^I, INPP5A^I, PLEK^I, ITGB3^I,II, ITGB1^II, ZA20D3^II, SH3BP5^II, DNM1L^II, RAB32^II, RAB6A^II, RSU1^II, RAB10^II, ANGPT1^II, ATP2C1^II, YWHAH^II, ARF4^II, RAB1A^II, RAB1B^II, CD226^II, RAC1^II, KIFAP3^II, PRKAR2B^II, PRKAR2A^II, ARL1^II, SAV1^II, RAB4A^II, GNG11^II, CD9^II, CD63^II, MYL6^II
Angiogenesis and cell differentiation	AKR1C3	MAPK14^I,II, THBS1^I, ANGPT1^II
Mitochondrial, ribosomal proteins	MRPS25, MRPS9, MRPS26, MRPL52	—
Tumor suppressor genes and oncogenes	EGR1, MYB, BRCA1	LOXL3^I, BNIP3L^II
Heat shock	HSPE1, ZRF1	—
Transport
Transport from ER to Golgi	—	BET1^II, RAB6A^II, INSIG2^II, ARF4^II, RAB1A^II
Transport of proteins	—	GABARAPL2^I,II, RAB10^II, ARL1^II, SNX3^II
Transport of ions, protons, electrons	—	SLC9A9^I,II, ABCC3^I, ATP2C1^I, SLC24A3^I, ATP6V0E^II, PDIA5^I, MAOB^I,II, SMOX^I, ME1^I, ATP6V1C1^II, ETFA^II, SQLE^II
Transport of adenine	—	VDAC3^II
Transport of chloride	—	CLIC4^I,II
Transport of lipid	—	CD36^II, SCP2^II
Transport of ammonium	—	RHAG^II
Receptors and integrins	TFRC, NPR3, FCER1A	ITGA6^I, EPOR^I, GPIBA^I, GP1BB^I, ACVR1^I, GP9^I, PLEK^I, PTCRA^I, CXCR4^I, PTGIR^I, ITGB3^I, LBR^II, ITGB1^II
Cytokines and chemokines	—	LEFTY1^I, CXCL5^I,II, CCL5^I, LOXL3^I, CKLF^I (variant 1, 3, 4), PF4V1^I, CKLFSF6^I,II, FAM3C^II
RNA processing, protein folding	PPIA, NOP5/NOP58, EIF5, NOLC1, RRN3, SNRPF, FBL, NXT1, HNRPA3, EMG1	EIF4E^I,II, PDIA5^I, PAM^I,II, PPIC^I, SKP1A^I, PCMT1^II, PTPN12^II, COPS4^II, SNX3^II, LIPA^II, STCH^II, INSIG2^II, QKI^II, PPP2CB^II, PPIA^II, SRP14^II, UBB^II, UBQLN1^II, DDX24^II, RNPS1^II
Transcription	ILF3, AATF, TIMELESS, TCF3, TRIM28, LRPPRC, THOC4, EGR1, EZH2, NPM1, E2F1, PFAS, CHAF1A, ITGB3BP	MAPK14^I,II, MAX^I, PRDX4^I, SALL2^I, SDCBP^II, TBPL1^II
HLA class I	—	HLA-C^I,II, HLA-G^I, HLA-F^I, HLA-E^I,II, HLA-B^II, B2M^II
HLA class II	HLA-DPB1, HLA-DRB5, HLA-DRA	—
Immune response	NPM	RGC32^I, PF4V1^I, IFITM3^I, GPI^II, ITGB1^II, Clorf32^II
Response to stress	—	SNN^I,II
Cell cycle cell proliferation	KNTC1, CHAF1A, NASP, MCM3, LRPPRC, E2F1, CDCA7, PKMYT1, CDC2L1, IFI16*	CDKN2D^I,† MAPRE2^I, MAPRE1^II, S100A10^I, SPARC^I,† YWHAH^II, MAPK14^I,II, INSIG1^II, CCNG1^II, PELO^II, CETN2^II, CCNA2^II, DBF4^II, RAD21^II
Positive regulation	E2F1	CXCL5^I,II, TTK^II
Negative regulation	NPM1, IGFBP7	PPP2CB^II, CDKN3^II
Apoptosis
Proapoptosis	E2F1, PDCD4, SIVA, CDC2L1	E2IG5^I, PRKCB1^I, BNIP3^I, CASP14^I, IFT57^I, HTAT1P2^I, BNIP3L^II, RTN4^II
Antiapoptosis	—	PRDX5^I, ALOX12^I, YWHAH^II
Chromosome organization and biogenesis	H2AFY	DCLRE1A^I, HIST1H3D^I,II, SKP1A^I, HIST1H2AC^II, RAD21^II
DNA replication, DNA recombination, and repair	LIG1, PFAS, RAD54L, RAD51, RFC5, CHAF1A, CHAF1B, MCM7, MCM4, MCM6, MCM3, MCM5, MCM2, UHRF1, SMARCA3, CHTF18, FEN1, CDC45L, RPA2, POLD3, MSH2, PCNA, MSH6, MGC5528	RAD21^II
Metabolism/biosynthesis	PAICS, FABP5, ADA, ALDH1A1, CTPS, AKR1C3, PRPS1, IMPDH2, DHFR, MTHFD1, RRM1, ACAA2, PFAS	EGLN3^I, SCD^I, FDPS^I, PRDX5^I, PRDX4^I, GUCY1B3^I, LOXL3^I, PAPSS2^I, ALOX12^I, AKI^I, HPSE^I, GGTLA4^I, GSTM3^I, MAOB^I,II, NT5C3^I, HGD^I, SLC16A3^I, SMOX^I, B3GALT4^I, IRS2^I, SQRDL^I, DGKD^I, GATM^I, PAPSS2^I, GCLM^I, ME1^I, PHKB^I, MTPN^I,II, GP1^II, PCMT1^II, CD36^II, LIPA^II, SAT^II, GBE1^II, INSIG1^II, SC5DL^II, SOLE^II, PLA2G4A^II, PELO^II, SCP2^II, PFAS^II, GALNT3^II, CMAS^II, ARL6IP^II, ADSL^II
Others	M27126, LCP1, MPO, SNX5, RANBP1, PLAC8, PLXND1, CD52, SSRP1, WDR21A, TIGAI	LZIC^I, LHFPL2^I, ACRBP^I, LTBP1^I, CLIC4^I, CLDN5^I, LCN2^I, ASTN2^I, HERC2P2^I, MGC15476^I, SNCA^I, ANKRD37^I, PRNP^I, DYNLT3^I,II, DKFZp564K142^I, TM9SF2^I, HSPC159^I, STARD3NL^I, EGFL6^I, TPARL^I,II, GPIAP1^II, GCA^II, GNB5^II, SH3BGRL2^II, MDM1^II, WRB^II, RNF11^II, SLC30A5^II, TM6SF1^II, SCOC^II, MRFAP1^II

	Down-regulated genes	Up-regulated genes
Cytoskeleton	SPTA1	MYH9^I, ACTB^I,II, DIAPH1^I, VCL^I, ACTN1^I, WDR1^I, KLHL5^I, CALD1^I, DSTN^I, TJP2^I, DAPP1^I, ZYX^I, STOM^I,II, SDCBP^I, CAPZA2^II, TPM1^II, RAC1^II, PTPN12^II, RAP1B^II, ACTR10^II, ACTR3^II, CKAP5^II
Microtubule dynamic	—	TUBA4^I,II, TUBA1^I, TUBB1^I, TUBA2^II, TUBA6^II
MK and platelet markers	PGDS	SELP^I, PECAM1^I, RAB27B^I, GP1BB^I, PF4V1^I, GP9^I, VWF^I, THBS1^I, ITGB3^I,II, GP1BA^I, STOM^I,II, CD63^II, ITGB1^II, CD36^II, CD226^II, RAP1B^II, CD47^I,II
Platelet adhesion, activation, aggregation, blood coagulation	—	SELP^I, PECAM1^I, GP1BA^I, GP1BB^I, ANXA3^I, F13A1^I, GP9^I, VWF^I, THBS1^I, ITGB3^I,II, CD9^II, CD63^II, CD36^II, SNAP23^II, RAPIB^II, CD47^I,II, PLA2G4A^II
Cell adhesion, migration, and motility	ITGB3BP	ITGA6^I, SELP^I, VCL^I, NID2^I, CCL5^I, CD47^I,II, GP9^I, VWF^I, ZYX^I, ALOX12^I, ITGB3^I,II, GP1BA^I, CD9^II, ITGB1^II, CD36^II, SSX21P^II, CD226^II, ITFG1^II, SDCBP^II, ACTB^I,II, CAPZA2^II, PTPN12^II, ACTR3^II, HMMR^II
Signal transduction	ITGB3BP, ANXA2	ITGA6^I, MYH9^I, CXCL5^I,II, DDEF2^I, LAT^I, MAPRE2^I, RYR2^I, ANXA3^I, NRGN^I, CCL5^I, RAB27B^I, CD47^I,II, RIT1^I, MAPK14^I,II, GRAP2^I, FYN^I, FYB^I, SPSB4^I, EHD3^I, RGS10^I, IRS2^I, ACVR1^I, SPARC^I, DAPP1^I, SDPR^I, ZYX^I, PTG1R^I, INPP5A^I, PLEK^I, ITGB3^I,II, ITGB1^II, ZA20D3^II, SH3BP5^II, DNM1L^II, RAB32^II, RAB6A^II, RSU1^II, RAB10^II, ANGPT1^II, ATP2C1^II, YWHAH^II, ARF4^II, RAB1A^II, RAB1B^II, CD226^II, RAC1^II, KIFAP3^II, PRKAR2B^II, PRKAR2A^II, ARL1^II, SAV1^II, RAB4A^II, GNG11^II, CD9^II, CD63^II, MYL6^II
Angiogenesis and cell differentiation	AKR1C3	MAPK14^I,II, THBS1^I, ANGPT1^II
Mitochondrial, ribosomal proteins	MRPS25, MRPS9, MRPS26, MRPL52	—
Tumor suppressor genes and oncogenes	EGR1, MYB, BRCA1	LOXL3^I, BNIP3L^II
Heat shock	HSPE1, ZRF1	—
Transport
Transport from ER to Golgi	—	BET1^II, RAB6A^II, INSIG2^II, ARF4^II, RAB1A^II
Transport of proteins	—	GABARAPL2^I,II, RAB10^II, ARL1^II, SNX3^II
Transport of ions, protons, electrons	—	SLC9A9^I,II, ABCC3^I, ATP2C1^I, SLC24A3^I, ATP6V0E^II, PDIA5^I, MAOB^I,II, SMOX^I, ME1^I, ATP6V1C1^II, ETFA^II, SQLE^II
Transport of adenine	—	VDAC3^II
Transport of chloride	—	CLIC4^I,II
Transport of lipid	—	CD36^II, SCP2^II
Transport of ammonium	—	RHAG^II
Receptors and integrins	TFRC, NPR3, FCER1A	ITGA6^I, EPOR^I, GPIBA^I, GP1BB^I, ACVR1^I, GP9^I, PLEK^I, PTCRA^I, CXCR4^I, PTGIR^I, ITGB3^I, LBR^II, ITGB1^II
Cytokines and chemokines	—	LEFTY1^I, CXCL5^I,II, CCL5^I, LOXL3^I, CKLF^I (variant 1, 3, 4), PF4V1^I, CKLFSF6^I,II, FAM3C^II
RNA processing, protein folding	PPIA, NOP5/NOP58, EIF5, NOLC1, RRN3, SNRPF, FBL, NXT1, HNRPA3, EMG1	EIF4E^I,II, PDIA5^I, PAM^I,II, PPIC^I, SKP1A^I, PCMT1^II, PTPN12^II, COPS4^II, SNX3^II, LIPA^II, STCH^II, INSIG2^II, QKI^II, PPP2CB^II, PPIA^II, SRP14^II, UBB^II, UBQLN1^II, DDX24^II, RNPS1^II
Transcription	ILF3, AATF, TIMELESS, TCF3, TRIM28, LRPPRC, THOC4, EGR1, EZH2, NPM1, E2F1, PFAS, CHAF1A, ITGB3BP	MAPK14^I,II, MAX^I, PRDX4^I, SALL2^I, SDCBP^II, TBPL1^II
HLA class I	—	HLA-C^I,II, HLA-G^I, HLA-F^I, HLA-E^I,II, HLA-B^II, B2M^II
HLA class II	HLA-DPB1, HLA-DRB5, HLA-DRA	—
Immune response	NPM	RGC32^I, PF4V1^I, IFITM3^I, GPI^II, ITGB1^II, Clorf32^II
Response to stress	—	SNN^I,II
Cell cycle cell proliferation	KNTC1, CHAF1A, NASP, MCM3, LRPPRC, E2F1, CDCA7, PKMYT1, CDC2L1, IFI16*	CDKN2D^I,† MAPRE2^I, MAPRE1^II, S100A10^I, SPARC^I,† YWHAH^II, MAPK14^I,II, INSIG1^II, CCNG1^II, PELO^II, CETN2^II, CCNA2^II, DBF4^II, RAD21^II
Positive regulation	E2F1	CXCL5^I,II, TTK^II
Negative regulation	NPM1, IGFBP7	PPP2CB^II, CDKN3^II
Apoptosis
Proapoptosis	E2F1, PDCD4, SIVA, CDC2L1	E2IG5^I, PRKCB1^I, BNIP3^I, CASP14^I, IFT57^I, HTAT1P2^I, BNIP3L^II, RTN4^II
Antiapoptosis	—	PRDX5^I, ALOX12^I, YWHAH^II
Chromosome organization and biogenesis	H2AFY	DCLRE1A^I, HIST1H3D^I,II, SKP1A^I, HIST1H2AC^II, RAD21^II
DNA replication, DNA recombination, and repair	LIG1, PFAS, RAD54L, RAD51, RFC5, CHAF1A, CHAF1B, MCM7, MCM4, MCM6, MCM3, MCM5, MCM2, UHRF1, SMARCA3, CHTF18, FEN1, CDC45L, RPA2, POLD3, MSH2, PCNA, MSH6, MGC5528	RAD21^II
Metabolism/biosynthesis	PAICS, FABP5, ADA, ALDH1A1, CTPS, AKR1C3, PRPS1, IMPDH2, DHFR, MTHFD1, RRM1, ACAA2, PFAS	EGLN3^I, SCD^I, FDPS^I, PRDX5^I, PRDX4^I, GUCY1B3^I, LOXL3^I, PAPSS2^I, ALOX12^I, AKI^I, HPSE^I, GGTLA4^I, GSTM3^I, MAOB^I,II, NT5C3^I, HGD^I, SLC16A3^I, SMOX^I, B3GALT4^I, IRS2^I, SQRDL^I, DGKD^I, GATM^I, PAPSS2^I, GCLM^I, ME1^I, PHKB^I, MTPN^I,II, GP1^II, PCMT1^II, CD36^II, LIPA^II, SAT^II, GBE1^II, INSIG1^II, SC5DL^II, SOLE^II, PLA2G4A^II, PELO^II, SCP2^II, PFAS^II, GALNT3^II, CMAS^II, ARL6IP^II, ADSL^II
Others	M27126, LCP1, MPO, SNX5, RANBP1, PLAC8, PLXND1, CD52, SSRP1, WDR21A, TIGAI	LZIC^I, LHFPL2^I, ACRBP^I, LTBP1^I, CLIC4^I, CLDN5^I, LCN2^I, ASTN2^I, HERC2P2^I, MGC15476^I, SNCA^I, ANKRD37^I, PRNP^I, DYNLT3^I,II, DKFZp564K142^I, TM9SF2^I, HSPC159^I, STARD3NL^I, EGFL6^I, TPARL^I,II, GPIAP1^II, GCA^II, GNB5^II, SH3BGRL2^II, MDM1^II, WRB^II, RNF11^II, SLC30A5^II, TM6SF1^II, SCOC^II, MRFAP1^II

— indicates not found. Superscripts I and II indicate the origin of the clusters containing up-regulated presented in Figure 2C.

Negative regulation.

†

Inhibitor.

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