Risk of NHL subtypes by family history of NHL, Hodgkin lymphoma, multiple myeloma, and leukemia, by sex, adjusted for age, education, race, and study left among cases and controls included in the InterLymph pooled analysis
| Family history . | Controls . | DLBCL . | Follicular . | Marginal zone . | Mantle-cell . | T-cell . | SLL/CLL . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||
| None | 10 776 | 2849 | 1.0 (reference) | 1703 | 1.0 (reference) | 288 | 1.0 (reference) | 142 | 1.0 (reference) | 378 | 1.0 (reference) | 1191 | 1.0 (reference) |
| NHL/NOS | 140 | 60 | 1.4 (1.1-2.0) | 55 | 1.8 (1.3-2.5) | 12 | 1.6 (0.9-2.9) | 8 | 1.9 (0.9-4.0) | 4 | 0.6 (0.2-1.7) | 21 | 1.5 (0.9-2.4) |
| Male relative | 47 | 28 | 2.0 (1.2-3.2) | 22 | 2.2 (1.3-3.7) | 7 | 2.8 (1.2-6.5) | 6 | 4.2 (1.7-10.3) | 3 | 1.3 (0.4-4.1) | 11 | 2.6 (1.3-5.1) |
| Female relative | 80 | 26 | 1.1 (0.7-1.7) | 32 | 1.7 (1.1-2.6) | 6 | 1.2 (0.5-2.7) | 2 | 0.7 (0.2-3.0) | 1 | 0.2 (0.03-1.8) | 7 | 1.0 (0.5-2.2) |
| Parent | 76 | 29 | 1.3 (0.8-2.0) | 26 | 1.5 (0.9-2.4) | 5 | 1.2 (0.5-3.1) | 5 | 2.3 (0.9-5.9) | 2 | 0.6 (0.1-2.3) | 8 | 1.2 (0.5-2.5) |
| Father | 27 | 15 | 1.8 (1.0-3.5) | 11 | 2.0 (1.0-4.0) | 1 | 0.8 (0.1-6.2) | 3 | 4.4 (1.3-15.4) | 1 | 0.8 (0.1-6.0) | 6 | 2.5 (1.0-6.3) |
| Mother | 49 | 14 | 0.9 (0.5-1.7) | 15 | 1.2 (0.7-2.3) | 4 | 1.3 (0.5-3.8) | 2 | 1.3 (0.3-5.6) | 1 | 0.4 (0.1-3.2) | 2 | 0.4 (0.1-1.8) |
| Sibling | 53 | 31 | 2.0 (1.3-3.1) | 25 | 2.3 (1.4-3.7) | 9 | 3.1 (1.5-6.4) | 3 | 1.7 (0.5-5.7) | 2 | 0.8 (0.2-3.4) | 12 | 2.0 (1.1-3.9) |
| Brother | 19 | 15 | 2.7 (1.4-5.4) | 10 | 2.6 (1.2-5.7) | 6 | 6.1 (2.3-16.1) | 3 | 4.9 (1.4-17.6) | 2 | 2.1 (0.5-9.1) | 5 | 2.5 (0.9-7.0) |
| Sister | 30 | 13 | 1.5 (0.8-2.8) | 15 | 2.2 (1.2-4.1) | 3 | 1.5 (0.4-5.0) | 0 | NA | 0 | NA | 5 | 1.7 (0.7-4.7) |
| Offspring | 13 | 1 | 0.3 (0.03-2.0) | 5 | 2.1 (0.7-5.9) | 0 | NA | 1 | 2.9 (0.4-23.9) | 0 | NA | 1 | 0.8 (0.1-6.2) |
| Parent/offspring | 89 | 30 | 1.1 (0.7-1.7) | 31 | 1.6 (1.0-2.4) | 5 | 1.0 (0.4-2.6) | 6 | 2.4 (1.0-5.7) | 2 | 0.5 (0.1-2.0) | 9 | 1.1 (0.5-2.2) |
| Hodgkin lymphoma | 55 | 27 | 1.7 (1.1-2.7) | 14 | 1.2 (0.7-2.3) | 3 | 1.3 (0.4-4.4) | 1 | 0.8 (0.1-5.9) | 2 | 1.0 (0.3-4.4) | 5 | 1.0 (0.4-2.5) |
| Male relative | 25 | 12 | 1.7 (0.8-3.4) | 11 | 2.0 (1.0-4.0) | 2 | 1.6 (0.4-6.8) | 1 | 1.5 (0.2-11.5) | 1 | 1.0 (0.1-7.4) | 5 | 2.8 (1.0-7.7) |
| Female relative | 28 | 12 | 1.5 (0.7-3.0) | 3 | 0.6 (0.2-1.9) | 1 | 1.0 (0.1-7.8) | 0 | NA | 1 | 1.1 (0.1-8.0) | 0 | NA |
| Parent | 26 | 13 | 1.7 (0.9-3.4) | 9 | 1.8 (0.8-3.9) | 2 | 1.8 (0.4-7.8) | 1 | 1.6 (0.2-12.1) | 1 | 1.1 (0.1-8.0) | 3 | 1.4 (0.4-4.7) |
| Father | 14 | 6 | 1.5 (0.6-3.9) | 7 | 2.3 (0.9-5.9) | 1 | 1.4 (0.2-11.0) | 1 | 2.7 (0.3-22.1) | 1 | 1.8 (0.2-14.1) | 3 | 3.7 (1.0-13.6) |
| Mother | 12 | 7 | 2.0 (0.8-5.3) | 2 | 1.0 (0.2-4.6) | 1 | 2.6 (0.3-22.0) | 0 | NA | 0 | NA | 0 | NA |
| Sibling | 21 | 8 | 1.3 (0.5-2.9) | 4 | 0.9 (0.3-2.6) | 1 | 1.0 (0.1-7.6) | 0 | NA | 1 | 1.2 (0.2-8.8) | 1 | 0.5 (0.1-3.9) |
| Brother | 10 | 4 | 1.4 (0.4-4.5) | 3 | 1.3 (0.3-4.7) | 1 | 1.9 (0.2-15.3) | 0 | NA | 0 | NA | 1 | 1.1 (0.1-8.5) |
| Sister | 11 | 4 | 1.1 (0.4-3.7) | 1 | 0.5 (0.1-3.7) | 0 | NA | 0 | NA | 1 | 2.1 (0.3-17.1) | 0 | NA |
| Offspring | 9 | 6 | 2.7 (0.9-7.6) | 1 | 0.5 (0.1-4.2) | 0 | NA | 0 | NA | 0 | NA | 1 | 1.1 (0.1-9.1) |
| Parent/offspring | 35 | 19 | 1.9 (1.1-3.4) | 10 | 1.4 (0.7-2.9) | 2 | 1.5 (0.4-6.5) | 1 | 1.3 (0.2-9.9) | 1 | 0.9 (0.1-6.5) | 4 | 1.3 (0.4-3.7) |
| Leukemia | 277 | 98 | 1.3 (1.0-1.6) | 54 | 1.1 (0.8-1.5) | 22 | 2.2 (1.4-3.6) | 11 | 2.3 (1.2-4.4) | 14 | 1.3 (0.8-2.3) | 71 | 2.2 (1.7-2.9) |
| Male relative | 138 | 39 | 1.0 (0.7-1.5) | 28 | 1.1 (0.7-1.6) | 10 | 1.8 (0.9-3.6) | 4 | 1.5 (0.5-4.1) | 6 | 1.0 (0.4-2.3) | 29 | 2.3 (1.5-3.5) |
| Female relative | 109 | 46 | 1.5 (1.1-2.2) | 22 | 1.0 (0.6-1.6) | 12 | 2.6 (1.4-4.9) | 7 | 3.2 (1.4-7.1) | 8 | 1.7 (0.8-3.5) | 20 | 1.9 (1.2-3.2) |
| Parent | 160 | 46 | 1.0 (0.7-1.4) | 33 | 1.1 (0.8-1.6) | 13 | 2.3 (1.3-4.2) | 6 | 2.3 (1.0-5.3) | 10 | 1.6 (0.8-3.0) | 40 | 2.5 (1.7-3.7) |
| Father | 87 | 24 | 1.0 (0.6-1.5) | 17 | 1.1 (0.6-1.8) | 8 | 2.5 (1.2-5.4) | 3 | 2.0 (0.6-6.7) | 3 | 0.8 (0.3-2.6) | 18 | 2.2 (1.3-3.8) |
| Mother | 74 | 22 | 1.1 (0.7-1.8) | 16 | 1.2 (0.7-2.0) | 5 | 2.0 (0.8-5.1) | 3 | 2.6 (0.8-8.7) | 7 | 2.6 (1.2-5.8) | 23 | 2.9 (1.8-4.8) |
| Sibling | 87 | 46 | 1.9 (1.3-2.8) | 16 | 1.1 (0.6-1.9) | 7 | 2.3 (1.0-5.1) | 4 | 2.5 (0.9-7.2) | 3 | 1.0 (0.3-3.1) | 24 | 2.0 (1.2-3.1) |
| Brother | 41 | 16 | 1.5 (0.8-2.6) | 9 | 1.3 (0.6-2.7) | 1 | 0.7 (0.1-5.0) | 1 | 1.1 (0.1-8.7) | 2 | 1.2 (0.3-5.1) | 12 | 2.7 (1.4-5.2) |
| Sister | 31 | 23 | 2.6 (1.5-4.5) | 7 | 1.1 (0.5-2.6) | 6 | 3.9 (1.6-9.8) | 3 | 4.1 (1.2-14.1) | 1 | 0.7 (0.1-5.1) | 4 | 1.3 (0.4-3.7) |
| Offspring | 32 | 7 | 0.8 (0.3-1.8) | 5 | 0.8 (0.3-2.2) | 2 | 1.7 (0.4-7.6) | 1 | 1.8 (0.2-14.0) | 1 | 0.8 (0.1-6.1) | 7 | 1.6 (0.7-3.7) |
| Parent/offspring | 191 | 52 | 1.0 (0.7-1.3) | 38 | 1.1 (0.8-1.5) | 15 | 2.2 (1.3-3.8) | 7 | 2.2 (1.0-4.8) | 11 | 1.5 (0.8-2.7) | 47 | 2.4 (1.7-3.3) |
| Multiple myeloma* | 38 | 13 | 1.2 (0.6-2.3) | 10 | 1.2 (0.6-2.4) | 4 | 2.0 (0.7-5.8) | 2 | 2.0 (0.5-8.7) | 5 | 2.8 (1.1-7.4) | 3 | 0.8 (0.3-2.8) |
| Male relative | 10 | 3 | 1.1 (0.3-4.0) | 7 | 3.1 (1.2-8.3) | 4 | 6.7 (2.0-22.4) | 2 | 5.3 (1.1-25.7) | 3 | 5.8 (1.6-21.4) | 1 | 1.1 (0.1-8.5) |
| Female relative | 27 | 8 | 1.0 (0.5-2.2) | 3 | 0.5 (0.1-1.5) | 0 | NA | 0 | NA | 2 | 1.5 (0.3-6.2) | 0 | NA |
| Parent | 27 | 9 | 1.2 (0.5-2.5) | 7 | 1.1 (0.5-2.5) | 3 | 1.9 (0.6-6.6) | 2 | 2.9 (0.7-12.7) | 5 | 3.6 (1.4-9.7) | 0 | NA |
| Sibling | 11 | 4 | 1.3 (0.4-4.3) | 3 | 1.4 (0.4-5.3) | 1 | 2.1 (0.3-17.1) | 0 | NA | 0 | NA | 3 | 2.2 (0.6-8.4) |
| Any of the above 4 | 499 | 190 | 1.3 (1.1-1.6) | 129 | 1.3 (1.1-1.6) | 40 | 1.9 (1.3-2.7) | 21 | 2.0 (1.2-3.2) | 25 | 1.2 (0.8-1.9) | 97 | 1.8 (1.5-2.3) |
| Male relative | 217 | 79 | 1.3 (1.0-1.7) | 68 | 1.6 (1.2-2.1) | 23 | 2.4 (1.5-3.7) | 13 | 2.5 (1.4-4.6) | 13 | 1.3 (0.7-2.3) | 46 | 2.4 (1.7-3.4) |
| Female relative | 241 | 90 | 1.3 (1.0-1.7) | 59 | 1.2 (0.9-1.6) | 19 | 1.6 (1.0-2.6) | 9 | 1.5 (0.8-3.1) | 12 | 1.1 (0.6-2.0) | 27 | 1.3 (0.8-1.9) |
| Parent | 285 | 96 | 1.2 (0.9-1.5) | 72 | 1.3 (1.0-1.6) | 22 | 1.8 (1.1-2.9) | 14 | 2.4 (1.3-4.2) | 18 | 1.5 (0.9-2.4) | 51 | 1.9 (1.4-2.7) |
| Father | 134 | 48 | 1.2 (0.9-1.7) | 40 | 1.5 (1.1-2.2) | 13 | 2.3 (1.3-4.3) | 9 | 3.2 (1.6-6.5) | 8 | 1.4 (0.7-2.8) | 27 | 2.3 (1.5-3.5) |
| Mother | 154 | 49 | 1.1 (0.8-1.6) | 35 | 1.1 (0.8-1.6) | 10 | 1.5 (0.8-2.9) | 5 | 1.6 (0.6-3.9) | 10 | 1.6 (0.8-3.1) | 25 | 1.7 (1.1-2.6) |
| Sibling | 168 | 85 | 1.8 (1.4-2.3) | 48 | 1.6 (1.1-2.2) | 18 | 2.5 (1.5-4.2) | 7 | 1.7 (0.8-3.9) | 6 | 0.9 (0.4-2.0) | 40 | 1.9 (1.3-2.8) |
| Brother | 73 | 34 | 1.7 (1.1-2.6) | 24 | 1.8 (1.1-2.8) | 9 | 2.9 (1.4-5.9) | 4 | 2.1 (0.7-6.0) | 4 | 1.3 (0.5-3.5) | 19 | 2.5 (1.5-4.2) |
| Sister | 77 | 41 | 1.8 (1.2-2.7) | 24 | 1.5 (0.9-2.4) | 9 | 2.1 (1.0-4.4) | 3 | 1.4 (0.4-4.6) | 2 | 0.5 (0.1-2.3) | 9 | 1.2 (0.6-2.5) |
| Offspring | 54 | 14 | 0.9 (0.5-1.7) | 11 | 1.1 (0.5-2.1) | 2 | 1.0 (0.2-4.1) | 2 | 2.0 (0.5-8.6) | 1 | 0.5 (0.1-3.8) | 9 | 1.4 (0.6-2.8) |
| Parent/offspring | 337 | 109 | 1.1 (0.9-1.4) | 82 | 1.2 (1.0-1.6) | 24 | 1.7 (1.1-2.7) | 16 | 2.3 (1.4-4.0) | 19 | 1.4 (0.8-2.2) | 60 | 1.8 (1.4-2.5) |
| Family history . | Controls . | DLBCL . | Follicular . | Marginal zone . | Mantle-cell . | T-cell . | SLL/CLL . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||
| None | 10 776 | 2849 | 1.0 (reference) | 1703 | 1.0 (reference) | 288 | 1.0 (reference) | 142 | 1.0 (reference) | 378 | 1.0 (reference) | 1191 | 1.0 (reference) |
| NHL/NOS | 140 | 60 | 1.4 (1.1-2.0) | 55 | 1.8 (1.3-2.5) | 12 | 1.6 (0.9-2.9) | 8 | 1.9 (0.9-4.0) | 4 | 0.6 (0.2-1.7) | 21 | 1.5 (0.9-2.4) |
| Male relative | 47 | 28 | 2.0 (1.2-3.2) | 22 | 2.2 (1.3-3.7) | 7 | 2.8 (1.2-6.5) | 6 | 4.2 (1.7-10.3) | 3 | 1.3 (0.4-4.1) | 11 | 2.6 (1.3-5.1) |
| Female relative | 80 | 26 | 1.1 (0.7-1.7) | 32 | 1.7 (1.1-2.6) | 6 | 1.2 (0.5-2.7) | 2 | 0.7 (0.2-3.0) | 1 | 0.2 (0.03-1.8) | 7 | 1.0 (0.5-2.2) |
| Parent | 76 | 29 | 1.3 (0.8-2.0) | 26 | 1.5 (0.9-2.4) | 5 | 1.2 (0.5-3.1) | 5 | 2.3 (0.9-5.9) | 2 | 0.6 (0.1-2.3) | 8 | 1.2 (0.5-2.5) |
| Father | 27 | 15 | 1.8 (1.0-3.5) | 11 | 2.0 (1.0-4.0) | 1 | 0.8 (0.1-6.2) | 3 | 4.4 (1.3-15.4) | 1 | 0.8 (0.1-6.0) | 6 | 2.5 (1.0-6.3) |
| Mother | 49 | 14 | 0.9 (0.5-1.7) | 15 | 1.2 (0.7-2.3) | 4 | 1.3 (0.5-3.8) | 2 | 1.3 (0.3-5.6) | 1 | 0.4 (0.1-3.2) | 2 | 0.4 (0.1-1.8) |
| Sibling | 53 | 31 | 2.0 (1.3-3.1) | 25 | 2.3 (1.4-3.7) | 9 | 3.1 (1.5-6.4) | 3 | 1.7 (0.5-5.7) | 2 | 0.8 (0.2-3.4) | 12 | 2.0 (1.1-3.9) |
| Brother | 19 | 15 | 2.7 (1.4-5.4) | 10 | 2.6 (1.2-5.7) | 6 | 6.1 (2.3-16.1) | 3 | 4.9 (1.4-17.6) | 2 | 2.1 (0.5-9.1) | 5 | 2.5 (0.9-7.0) |
| Sister | 30 | 13 | 1.5 (0.8-2.8) | 15 | 2.2 (1.2-4.1) | 3 | 1.5 (0.4-5.0) | 0 | NA | 0 | NA | 5 | 1.7 (0.7-4.7) |
| Offspring | 13 | 1 | 0.3 (0.03-2.0) | 5 | 2.1 (0.7-5.9) | 0 | NA | 1 | 2.9 (0.4-23.9) | 0 | NA | 1 | 0.8 (0.1-6.2) |
| Parent/offspring | 89 | 30 | 1.1 (0.7-1.7) | 31 | 1.6 (1.0-2.4) | 5 | 1.0 (0.4-2.6) | 6 | 2.4 (1.0-5.7) | 2 | 0.5 (0.1-2.0) | 9 | 1.1 (0.5-2.2) |
| Hodgkin lymphoma | 55 | 27 | 1.7 (1.1-2.7) | 14 | 1.2 (0.7-2.3) | 3 | 1.3 (0.4-4.4) | 1 | 0.8 (0.1-5.9) | 2 | 1.0 (0.3-4.4) | 5 | 1.0 (0.4-2.5) |
| Male relative | 25 | 12 | 1.7 (0.8-3.4) | 11 | 2.0 (1.0-4.0) | 2 | 1.6 (0.4-6.8) | 1 | 1.5 (0.2-11.5) | 1 | 1.0 (0.1-7.4) | 5 | 2.8 (1.0-7.7) |
| Female relative | 28 | 12 | 1.5 (0.7-3.0) | 3 | 0.6 (0.2-1.9) | 1 | 1.0 (0.1-7.8) | 0 | NA | 1 | 1.1 (0.1-8.0) | 0 | NA |
| Parent | 26 | 13 | 1.7 (0.9-3.4) | 9 | 1.8 (0.8-3.9) | 2 | 1.8 (0.4-7.8) | 1 | 1.6 (0.2-12.1) | 1 | 1.1 (0.1-8.0) | 3 | 1.4 (0.4-4.7) |
| Father | 14 | 6 | 1.5 (0.6-3.9) | 7 | 2.3 (0.9-5.9) | 1 | 1.4 (0.2-11.0) | 1 | 2.7 (0.3-22.1) | 1 | 1.8 (0.2-14.1) | 3 | 3.7 (1.0-13.6) |
| Mother | 12 | 7 | 2.0 (0.8-5.3) | 2 | 1.0 (0.2-4.6) | 1 | 2.6 (0.3-22.0) | 0 | NA | 0 | NA | 0 | NA |
| Sibling | 21 | 8 | 1.3 (0.5-2.9) | 4 | 0.9 (0.3-2.6) | 1 | 1.0 (0.1-7.6) | 0 | NA | 1 | 1.2 (0.2-8.8) | 1 | 0.5 (0.1-3.9) |
| Brother | 10 | 4 | 1.4 (0.4-4.5) | 3 | 1.3 (0.3-4.7) | 1 | 1.9 (0.2-15.3) | 0 | NA | 0 | NA | 1 | 1.1 (0.1-8.5) |
| Sister | 11 | 4 | 1.1 (0.4-3.7) | 1 | 0.5 (0.1-3.7) | 0 | NA | 0 | NA | 1 | 2.1 (0.3-17.1) | 0 | NA |
| Offspring | 9 | 6 | 2.7 (0.9-7.6) | 1 | 0.5 (0.1-4.2) | 0 | NA | 0 | NA | 0 | NA | 1 | 1.1 (0.1-9.1) |
| Parent/offspring | 35 | 19 | 1.9 (1.1-3.4) | 10 | 1.4 (0.7-2.9) | 2 | 1.5 (0.4-6.5) | 1 | 1.3 (0.2-9.9) | 1 | 0.9 (0.1-6.5) | 4 | 1.3 (0.4-3.7) |
| Leukemia | 277 | 98 | 1.3 (1.0-1.6) | 54 | 1.1 (0.8-1.5) | 22 | 2.2 (1.4-3.6) | 11 | 2.3 (1.2-4.4) | 14 | 1.3 (0.8-2.3) | 71 | 2.2 (1.7-2.9) |
| Male relative | 138 | 39 | 1.0 (0.7-1.5) | 28 | 1.1 (0.7-1.6) | 10 | 1.8 (0.9-3.6) | 4 | 1.5 (0.5-4.1) | 6 | 1.0 (0.4-2.3) | 29 | 2.3 (1.5-3.5) |
| Female relative | 109 | 46 | 1.5 (1.1-2.2) | 22 | 1.0 (0.6-1.6) | 12 | 2.6 (1.4-4.9) | 7 | 3.2 (1.4-7.1) | 8 | 1.7 (0.8-3.5) | 20 | 1.9 (1.2-3.2) |
| Parent | 160 | 46 | 1.0 (0.7-1.4) | 33 | 1.1 (0.8-1.6) | 13 | 2.3 (1.3-4.2) | 6 | 2.3 (1.0-5.3) | 10 | 1.6 (0.8-3.0) | 40 | 2.5 (1.7-3.7) |
| Father | 87 | 24 | 1.0 (0.6-1.5) | 17 | 1.1 (0.6-1.8) | 8 | 2.5 (1.2-5.4) | 3 | 2.0 (0.6-6.7) | 3 | 0.8 (0.3-2.6) | 18 | 2.2 (1.3-3.8) |
| Mother | 74 | 22 | 1.1 (0.7-1.8) | 16 | 1.2 (0.7-2.0) | 5 | 2.0 (0.8-5.1) | 3 | 2.6 (0.8-8.7) | 7 | 2.6 (1.2-5.8) | 23 | 2.9 (1.8-4.8) |
| Sibling | 87 | 46 | 1.9 (1.3-2.8) | 16 | 1.1 (0.6-1.9) | 7 | 2.3 (1.0-5.1) | 4 | 2.5 (0.9-7.2) | 3 | 1.0 (0.3-3.1) | 24 | 2.0 (1.2-3.1) |
| Brother | 41 | 16 | 1.5 (0.8-2.6) | 9 | 1.3 (0.6-2.7) | 1 | 0.7 (0.1-5.0) | 1 | 1.1 (0.1-8.7) | 2 | 1.2 (0.3-5.1) | 12 | 2.7 (1.4-5.2) |
| Sister | 31 | 23 | 2.6 (1.5-4.5) | 7 | 1.1 (0.5-2.6) | 6 | 3.9 (1.6-9.8) | 3 | 4.1 (1.2-14.1) | 1 | 0.7 (0.1-5.1) | 4 | 1.3 (0.4-3.7) |
| Offspring | 32 | 7 | 0.8 (0.3-1.8) | 5 | 0.8 (0.3-2.2) | 2 | 1.7 (0.4-7.6) | 1 | 1.8 (0.2-14.0) | 1 | 0.8 (0.1-6.1) | 7 | 1.6 (0.7-3.7) |
| Parent/offspring | 191 | 52 | 1.0 (0.7-1.3) | 38 | 1.1 (0.8-1.5) | 15 | 2.2 (1.3-3.8) | 7 | 2.2 (1.0-4.8) | 11 | 1.5 (0.8-2.7) | 47 | 2.4 (1.7-3.3) |
| Multiple myeloma* | 38 | 13 | 1.2 (0.6-2.3) | 10 | 1.2 (0.6-2.4) | 4 | 2.0 (0.7-5.8) | 2 | 2.0 (0.5-8.7) | 5 | 2.8 (1.1-7.4) | 3 | 0.8 (0.3-2.8) |
| Male relative | 10 | 3 | 1.1 (0.3-4.0) | 7 | 3.1 (1.2-8.3) | 4 | 6.7 (2.0-22.4) | 2 | 5.3 (1.1-25.7) | 3 | 5.8 (1.6-21.4) | 1 | 1.1 (0.1-8.5) |
| Female relative | 27 | 8 | 1.0 (0.5-2.2) | 3 | 0.5 (0.1-1.5) | 0 | NA | 0 | NA | 2 | 1.5 (0.3-6.2) | 0 | NA |
| Parent | 27 | 9 | 1.2 (0.5-2.5) | 7 | 1.1 (0.5-2.5) | 3 | 1.9 (0.6-6.6) | 2 | 2.9 (0.7-12.7) | 5 | 3.6 (1.4-9.7) | 0 | NA |
| Sibling | 11 | 4 | 1.3 (0.4-4.3) | 3 | 1.4 (0.4-5.3) | 1 | 2.1 (0.3-17.1) | 0 | NA | 0 | NA | 3 | 2.2 (0.6-8.4) |
| Any of the above 4 | 499 | 190 | 1.3 (1.1-1.6) | 129 | 1.3 (1.1-1.6) | 40 | 1.9 (1.3-2.7) | 21 | 2.0 (1.2-3.2) | 25 | 1.2 (0.8-1.9) | 97 | 1.8 (1.5-2.3) |
| Male relative | 217 | 79 | 1.3 (1.0-1.7) | 68 | 1.6 (1.2-2.1) | 23 | 2.4 (1.5-3.7) | 13 | 2.5 (1.4-4.6) | 13 | 1.3 (0.7-2.3) | 46 | 2.4 (1.7-3.4) |
| Female relative | 241 | 90 | 1.3 (1.0-1.7) | 59 | 1.2 (0.9-1.6) | 19 | 1.6 (1.0-2.6) | 9 | 1.5 (0.8-3.1) | 12 | 1.1 (0.6-2.0) | 27 | 1.3 (0.8-1.9) |
| Parent | 285 | 96 | 1.2 (0.9-1.5) | 72 | 1.3 (1.0-1.6) | 22 | 1.8 (1.1-2.9) | 14 | 2.4 (1.3-4.2) | 18 | 1.5 (0.9-2.4) | 51 | 1.9 (1.4-2.7) |
| Father | 134 | 48 | 1.2 (0.9-1.7) | 40 | 1.5 (1.1-2.2) | 13 | 2.3 (1.3-4.3) | 9 | 3.2 (1.6-6.5) | 8 | 1.4 (0.7-2.8) | 27 | 2.3 (1.5-3.5) |
| Mother | 154 | 49 | 1.1 (0.8-1.6) | 35 | 1.1 (0.8-1.6) | 10 | 1.5 (0.8-2.9) | 5 | 1.6 (0.6-3.9) | 10 | 1.6 (0.8-3.1) | 25 | 1.7 (1.1-2.6) |
| Sibling | 168 | 85 | 1.8 (1.4-2.3) | 48 | 1.6 (1.1-2.2) | 18 | 2.5 (1.5-4.2) | 7 | 1.7 (0.8-3.9) | 6 | 0.9 (0.4-2.0) | 40 | 1.9 (1.3-2.8) |
| Brother | 73 | 34 | 1.7 (1.1-2.6) | 24 | 1.8 (1.1-2.8) | 9 | 2.9 (1.4-5.9) | 4 | 2.1 (0.7-6.0) | 4 | 1.3 (0.5-3.5) | 19 | 2.5 (1.5-4.2) |
| Sister | 77 | 41 | 1.8 (1.2-2.7) | 24 | 1.5 (0.9-2.4) | 9 | 2.1 (1.0-4.4) | 3 | 1.4 (0.4-4.6) | 2 | 0.5 (0.1-2.3) | 9 | 1.2 (0.6-2.5) |
| Offspring | 54 | 14 | 0.9 (0.5-1.7) | 11 | 1.1 (0.5-2.1) | 2 | 1.0 (0.2-4.1) | 2 | 2.0 (0.5-8.6) | 1 | 0.5 (0.1-3.8) | 9 | 1.4 (0.6-2.8) |
| Parent/offspring | 337 | 109 | 1.1 (0.9-1.4) | 82 | 1.2 (1.0-1.6) | 24 | 1.7 (1.1-2.7) | 16 | 2.3 (1.4-4.0) | 19 | 1.4 (0.8-2.2) | 60 | 1.8 (1.4-2.5) |
Known HIV-infected individuals are excluded from the analysis.
NOS indicates non-Hodgkin lymphoma or lymphoma not otherwise specified; and NA, estimates were not available or unstable due to small numbers.
No offspring with MM.