Table 1. Summary of the characteristics... | American Society of Hematology

Table 1.

Summary of the characteristics of different FANCA mutants

Mutant	Interaction L*	Interaction B/L†	Interaction G*	Localization	Possible defect
L210R	—	—	—	C	Interaction FANCG
L274P	—	—	+	C	Conformation
H492R	—	+	±	C‡	Phosphorylation
Y510C	—	+	±	C	Phosphorylation
R1055L	±	—	+	C + N‡	Interaction B/L

Mutant	Interaction L*	Interaction B/L†	Interaction G*	Localization	Possible defect
L210R	—	—	—	C	Interaction FANCG
L274P	—	—	+	C	Conformation
H492R	—	+	±	C‡	Phosphorylation
Y510C	—	+	±	C	Phosphorylation
R1055L	±	—	+	C + N‡	Interaction B/L

—indicates no interaction; C, predominantly cytoplasmic; +, normal interaction; ±, weak interaction; and C + N cytoplasmic and nuclear.

Immunoprecipitation.

Mammalian 3-hybrid assay.

Described by Adachi et al.³⁰