MPL 1544 G>T and MPL 1543 TG>AA (W515) genotyping of blood fractionated cell populations
| . | Peripheral progenitors cells . | Peripheral myeloid cells . | Peripheral lymphoid cells . | |||||
|---|---|---|---|---|---|---|---|---|
| 34+/38− . | 34+/38+ . | Gr . | Pl . | Mo . | NK . | B . | T . | |
| PMF 1 MPL W515L | ND | ND | + | +++ | − | − | − | − |
| PMF 2 MPL W515L | +++ | +++ | ++ | ND | +++ | +++ | − | − |
| PMF 3 MPL W515K | ++ | ++ | ++ | ++ | ND | ++ | − | − |
| . | Peripheral progenitors cells . | Peripheral myeloid cells . | Peripheral lymphoid cells . | |||||
|---|---|---|---|---|---|---|---|---|
| 34+/38− . | 34+/38+ . | Gr . | Pl . | Mo . | NK . | B . | T . | |
| PMF 1 MPL W515L | ND | ND | + | +++ | − | − | − | − |
| PMF 2 MPL W515L | +++ | +++ | ++ | ND | +++ | +++ | − | − |
| PMF 3 MPL W515K | ++ | ++ | ++ | ++ | ND | ++ | − | − |
Gr indicates granulocytes; Pl, platelets, Mo, monocytes, NK, natural killer cells, B, lymphocyte B cells, T, lymphocyte T cells; ND, no data; +, MPL W515 5% to 25%; ++, MPL W515 25% to 50%; +++, MPL W515 over 50%; and −, absence of the MPL W515 mutation.