Univariate analysis of the prognostic value of OPAL1 expression in pediatric ALL
. | COALL . | . | . | . | St Jude . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | N . | 4-y DFS, % ± SE . | OPAL1 categorical variable P*(HR) . | OPAL1 continuous variable P†(HR) . | N . | 4-y DFS, % ± SE . | OPAL1 categorical variable P*(HR) . | OPAL1 continuous variable P†(HR) . | ||||||
| Total group | ||||||||||||||
| Low‡ | 60 | 78 ± 5 | -(1.00) | 85 | 86 ± 4 | -(1.00) | ||||||||
| Intermediate | 60 | 63 ± 7 | .07 (1.88) | .45 (0.92) | 86 | 82 ± 4 | .33 (1.37) | < .001§ (0.62) | ||||||
| High | 60 | 87 ± 5 | .28 (0.61) | 86 | 96 ± 2 | .01§ (0.28) | ||||||||
| B-lineage | ||||||||||||||
| Low‡ | 48 | 79 ± 6 | -(1.00) | 73 | 87 ± 4 | -(1.00) | ||||||||
| Intermediate | 49 | 69 ± 7 | .33 (1.49) | .078 (0.81) | 73 | 89 ± 4 | .68 (1.18) | < .001§ (0.56) | ||||||
| High | 48 | 91 ± 5 | .18 (0.48) | 73 | 97 ± 2 | .02 (0.23) | ||||||||
| T-lineage | ||||||||||||||
| Low‡ | 12 | 92 ± 8 | -(1.00) | 12 | 75 ± 13 | -(1.00) | ||||||||
| Intermediate | 11 | 50 ± 16 | .06 (7.90) | .06 (1.9) | 13 | 67 ± 14 | .86 (1.14) | .34 (1.58) | ||||||
| High | 12 | 42 ± 14 | .03 (9.80) | 13 | 69 ± 13 | .76 (1.22) | ||||||||
| Non-TEL-AML1 | ||||||||||||||
| Low‡ | 34 | 76 ± 7 | -(1.00) | 49 | 87 ± 5 | -(1.00) | ||||||||
| Intermediate | 33 | 75 ± 8 | .93 (1.04) | .84 (0.97) | 50 | 84 ± 5 | .23 (1.76) | .35 (0.76) | ||||||
| High | 34 | 66 ± 9 | .55 (1.33) | 50 | 96 ± 3 | .52 (0.69) | ||||||||
| TEL-AML1 | ||||||||||||||
| Low‡ | 15 | 92 ± 3 | -(1.00) | 23 | 87 ± 7 | -(1.00) | ||||||||
| Intermediate | 14 | 92 ± 7 | .89 (0.82) | .61 (0.70) | 24 | 100 | .17 (0.23) | < .001§ (0.07) | ||||||
| High | 15 | 100 | .97 (0.94) | 23 | 100 | ND | ||||||||
. | COALL . | . | . | . | St Jude . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | N . | 4-y DFS, % ± SE . | OPAL1 categorical variable P*(HR) . | OPAL1 continuous variable P†(HR) . | N . | 4-y DFS, % ± SE . | OPAL1 categorical variable P*(HR) . | OPAL1 continuous variable P†(HR) . | ||||||
| Total group | ||||||||||||||
| Low‡ | 60 | 78 ± 5 | -(1.00) | 85 | 86 ± 4 | -(1.00) | ||||||||
| Intermediate | 60 | 63 ± 7 | .07 (1.88) | .45 (0.92) | 86 | 82 ± 4 | .33 (1.37) | < .001§ (0.62) | ||||||
| High | 60 | 87 ± 5 | .28 (0.61) | 86 | 96 ± 2 | .01§ (0.28) | ||||||||
| B-lineage | ||||||||||||||
| Low‡ | 48 | 79 ± 6 | -(1.00) | 73 | 87 ± 4 | -(1.00) | ||||||||
| Intermediate | 49 | 69 ± 7 | .33 (1.49) | .078 (0.81) | 73 | 89 ± 4 | .68 (1.18) | < .001§ (0.56) | ||||||
| High | 48 | 91 ± 5 | .18 (0.48) | 73 | 97 ± 2 | .02 (0.23) | ||||||||
| T-lineage | ||||||||||||||
| Low‡ | 12 | 92 ± 8 | -(1.00) | 12 | 75 ± 13 | -(1.00) | ||||||||
| Intermediate | 11 | 50 ± 16 | .06 (7.90) | .06 (1.9) | 13 | 67 ± 14 | .86 (1.14) | .34 (1.58) | ||||||
| High | 12 | 42 ± 14 | .03 (9.80) | 13 | 69 ± 13 | .76 (1.22) | ||||||||
| Non-TEL-AML1 | ||||||||||||||
| Low‡ | 34 | 76 ± 7 | -(1.00) | 49 | 87 ± 5 | -(1.00) | ||||||||
| Intermediate | 33 | 75 ± 8 | .93 (1.04) | .84 (0.97) | 50 | 84 ± 5 | .23 (1.76) | .35 (0.76) | ||||||
| High | 34 | 66 ± 9 | .55 (1.33) | 50 | 96 ± 3 | .52 (0.69) | ||||||||
| TEL-AML1 | ||||||||||||||
| Low‡ | 15 | 92 ± 3 | -(1.00) | 23 | 87 ± 7 | -(1.00) | ||||||||
| Intermediate | 14 | 92 ± 7 | .89 (0.82) | .61 (0.70) | 24 | 100 | .17 (0.23) | < .001§ (0.07) | ||||||
| High | 15 | 100 | .97 (0.94) | 23 | 100 | ND | ||||||||
Overview of DFS analyses for low, intermediate, and high OPAL1 expression in COALL and St Jude study cohorts in the total group of pediatric ALL patients, within B-lineage and T-lineage ALL patients, and within genetic subgroups of ALL that were associated with OPAL1 expression in COALL patients and St Jude patients. Dashes have been inserted for the P values of the reference groups.
HR indicates hazard ratio; ND, not detected (ie, no events occurred).
Cox univariate analysis adjusted for competing events; OPAL1 expression categorical.
OPAL1 expression continuous variable.
Reference group.
Significant after Bonferroni correction.