Table 1. OPAL1 expression in prognostic... | American Society of Hematology

Table 1.

OPAL1 expression in prognostic subgroups of ALL at diagnosis

	COALL					St Jude
Variable	N	Ratio	P	N	Ratio	P
Age
No older than 10 y	131	1.00*		181	1.00*
Older than 10 y	49	0.86	.39	76	0.87	.001†
WBC count
Less than 10 × 10⁹/L	43	1.00*		90	1.00*
10 × 10⁹-49 × 10⁹/L	67	0.91	.97	80	1.11	.42
50 × 10⁹-100 × 10⁹/L	28	1.04	.93	40	1.05	.88
More than 100 × 10⁹/L	42	1.04	.76	47	0.85	.023
Sex
Female	76	1.00*		95	1.00*
Male	104	1.00	.74	162	1.09	.53
ALL subtype
B-other	53	1.00*		82	1.00*
BCR-ABL	4	0.89	.74	9	1.02	.63
Hyperdiploid‡	40	0.94	.47	50	1.17	.002†
MLL rearranged	4	1.23	.79	8	1.10	.19
TEL-AML1	44	2.69	< .001†	70	2.82	< .001†
T-lineage	35	1.13	.32	38	1.10	.056

	COALL					St Jude
Variable	N	Ratio	P	N	Ratio	P
Age
No older than 10 y	131	1.00*		181	1.00*
Older than 10 y	49	0.86	.39	76	0.87	.001†
WBC count
Less than 10 × 10⁹/L	43	1.00*		90	1.00*
10 × 10⁹-49 × 10⁹/L	67	0.91	.97	80	1.11	.42
50 × 10⁹-100 × 10⁹/L	28	1.04	.93	40	1.05	.88
More than 100 × 10⁹/L	42	1.04	.76	47	0.85	.023
Sex
Female	76	1.00*		95	1.00*
Male	104	1.00	.74	162	1.09	.53
ALL subtype
B-other	53	1.00*		82	1.00*
BCR-ABL	4	0.89	.74	9	1.02	.63
Hyperdiploid‡	40	0.94	.47	50	1.17	.002†
MLL rearranged	4	1.23	.79	8	1.10	.19
TEL-AML1	44	2.69	< .001†	70	2.82	< .001†
T-lineage	35	1.13	.32	38	1.10	.056

OPAL1 expression was compared in prognostic ALL subgroups defined by age, WBC count, sex, immunophenotype, and genetic subtype in children treated on COALL and St Jude protocols. Indicated are the number of patients (N) for each group, the ratio of OPAL1 expression in nonreference versus reference groups (fold difference in median scaled OPAL1 expression), and P values comparing the nonreference versus reference group determined by the Mann-Whitney U test.

Reference group.

†

Significant after Bonferroni correction.

‡

Cytogenetic analysis revealed more than 50 chromosomes.

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