Grade 3 or 4 toxicities during induction therapy by age group
| Grade 3 or 4 toxicity . | Percentage grade 3 or 4 toxicity by age, y . | P . | |
|---|---|---|---|
| Age, younger than 60 . | Age, 60 y or older . | ||
| Anemia | 62 | 69 | .007 |
| Thrombocytopenia | 70 | 74 | .08 |
| Neutropenia | 90 | 91 | NS |
| Fever of unknown origin | 33 | 27 | .008 |
| Documented infection | 58 | 70 | <.001 |
| Hospitalization | 91 | 96 | <.001 |
| Renal | 2 | 4 | .03 |
| Hepatic | 20 | 24 | .04 |
| Cardiac | 1 | 3 | .04 |
| Dialysis | 4 | 9 | .002 |
| Admission to intensive care unit | 22 | 34 | <.001 |
| Mechanical ventilation | 11 | 20 | <.001 |
| Hyponatremia | 14 | 19 | .007 |
| Hypokalemia | 32 | 34 | NS |
| Nausea and vomiting | 3 | 2 | NS |
| Diarrhea | 9 | 4 | <.001 |
| Mucositis | 4 | 4 | NS |
| Grade 3 or 4 toxicity . | Percentage grade 3 or 4 toxicity by age, y . | P . | |
|---|---|---|---|
| Age, younger than 60 . | Age, 60 y or older . | ||
| Anemia | 62 | 69 | .007 |
| Thrombocytopenia | 70 | 74 | .08 |
| Neutropenia | 90 | 91 | NS |
| Fever of unknown origin | 33 | 27 | .008 |
| Documented infection | 58 | 70 | <.001 |
| Hospitalization | 91 | 96 | <.001 |
| Renal | 2 | 4 | .03 |
| Hepatic | 20 | 24 | .04 |
| Cardiac | 1 | 3 | .04 |
| Dialysis | 4 | 9 | .002 |
| Admission to intensive care unit | 22 | 34 | <.001 |
| Mechanical ventilation | 11 | 20 | <.001 |
| Hyponatremia | 14 | 19 | .007 |
| Hypokalemia | 32 | 34 | NS |
| Nausea and vomiting | 3 | 2 | NS |
| Diarrhea | 9 | 4 | <.001 |
| Mucositis | 4 | 4 | NS |
NS indicates not statistically significant, P > .05.