Presenting adverse features of the study group with age younger than 60 years (n = 811) versus age 60 years or older (n = 723)
| Parameter/category . | Percentage . | P . | ||
|---|---|---|---|---|
| All . | Age, younger than 60 y . | Age, 60 y or older . | ||
| Percent of total [n] | 100 [1534] | 53 [811] | 47 [723] | |
| Sex, female | 42 | 48 | 34 | <.001 |
| Diagnosis | ||||
| AML | 88 | 90 | 85 | |
| MDS | 12 | 10 | 15 | .008 |
| Hemoglobin level, g/L, lower than 80 | 50 | 51 | 50 | NS |
| Granulocyte count, × 109/L | ||||
| 0.5 to less than 1.0 | 14 | 14 | 14 | NS |
| Less than 0.5 | 34 | 33 | 34 | NS |
| Platelet count, × 109/L | ||||
| 50 to 99 | 28 | 28 | 27 | NS |
| 20 to 49 | 36 | 39 | 33 | .01 |
| Less than 20 | 16 | 14 | 19 | .01 |
| Karyotype | ||||
| t(8;21), inversion 16 | 9 | 14 | 3 | <.001 |
| Normal | 36 | 33 | 40 | .01 |
| 5 or 7 abnormalities | 25 | 23 | 27 | NS |
| Other abnormalities | 26 | 25 | 26 | NS |
| IM/not done | 5 | 5 | 5 | NS |
| Fever | ||||
| FUO | 16 | 18 | 13 | .007 |
| Pneumonia | 12 | 12 | 12 | NS |
| Other infections | 8 | 9 | 8 | NS |
| Creatinine, mg % | ||||
| Over 2 | 3 | 2 | 5 | .001 |
| 1.3 to 2 | 15 | 9 | 21 | <.001 |
| Bilirubin, mg % | ||||
| Over 2 | 3 | 3 | 3 | NS |
| 1.3 to 2 | 7 | 7 | 7 | NS |
| Fatal bleeding, yes (n) | <1(10) | <1 (4) | <1 (6) | NS |
| Admission to ICU, yes | 9 | 9 | 10 | NS |
| Parameter/category . | Percentage . | P . | ||
|---|---|---|---|---|
| All . | Age, younger than 60 y . | Age, 60 y or older . | ||
| Percent of total [n] | 100 [1534] | 53 [811] | 47 [723] | |
| Sex, female | 42 | 48 | 34 | <.001 |
| Diagnosis | ||||
| AML | 88 | 90 | 85 | |
| MDS | 12 | 10 | 15 | .008 |
| Hemoglobin level, g/L, lower than 80 | 50 | 51 | 50 | NS |
| Granulocyte count, × 109/L | ||||
| 0.5 to less than 1.0 | 14 | 14 | 14 | NS |
| Less than 0.5 | 34 | 33 | 34 | NS |
| Platelet count, × 109/L | ||||
| 50 to 99 | 28 | 28 | 27 | NS |
| 20 to 49 | 36 | 39 | 33 | .01 |
| Less than 20 | 16 | 14 | 19 | .01 |
| Karyotype | ||||
| t(8;21), inversion 16 | 9 | 14 | 3 | <.001 |
| Normal | 36 | 33 | 40 | .01 |
| 5 or 7 abnormalities | 25 | 23 | 27 | NS |
| Other abnormalities | 26 | 25 | 26 | NS |
| IM/not done | 5 | 5 | 5 | NS |
| Fever | ||||
| FUO | 16 | 18 | 13 | .007 |
| Pneumonia | 12 | 12 | 12 | NS |
| Other infections | 8 | 9 | 8 | NS |
| Creatinine, mg % | ||||
| Over 2 | 3 | 2 | 5 | .001 |
| 1.3 to 2 | 15 | 9 | 21 | <.001 |
| Bilirubin, mg % | ||||
| Over 2 | 3 | 3 | 3 | NS |
| 1.3 to 2 | 7 | 7 | 7 | NS |
| Fatal bleeding, yes (n) | <1(10) | <1 (4) | <1 (6) | NS |
| Admission to ICU, yes | 9 | 9 | 10 | NS |
AML indicates acute myeloid leukemia, MDS, myelodysplastic syndrome; FUO, fever of unknown origin; IM, insufficient metaphases; and NS, not statistically significant, P > .05.