Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between nutritional factors of one-carbon metabolism and non-Hodgkin lymphoma, stratified by selected genetic polymorphisms, the NCI-SEER Study, 1998-2000
| Nutritional factor, genotype . | Dietary intake levels of nutrients . | P interaction . | ||
|---|---|---|---|---|
| Low, less than median . | High, median or higher . | |||
| No. of cases/controls* . | No. of cases/controls* . | OR (95% CI) . | ||
| Vitamin B6 | ||||
| Combined genotypes | 237/162 | 149/157 | 0.70 (0.51-0.95) | N/A |
| FPGS Ex15-263T>C | ||||
| TT | 69/59 | 57/49 | 1.03 (0.61-1.74) | |
| CT | 104/81 | 67/79 | 0.71 (0.46-1.12) | |
| CC | 59/17 | 20/27 | 0.22 (0.10-0.52) | .002 |
| MTHFS IVS2-1411T>G | ||||
| TT/TG | 149/89 | 85/99 | 0.54 (0.36-0.81) | |
| GG | 18/26 | 14/16 | 1.68 (0.61-4.65) | .06 |
| MTR Ex26-20A>G | ||||
| AA | 117/78 | 69/91 | 0.55 (0.35-0.86) | |
| AG/GG | 50/44 | 36/28 | 1.20 (0.62-2.33) | .05 |
| Methionine | ||||
| Combined genotypes | 225/164 | 161/155 | 0.82 (0.60-1.11) | N/A |
| FTHFD Ex10-40G>T | ||||
| GG | 179/112 | 105/112 | 0.63 (0.44-0.91) | |
| GT/TT | 43/44 | 51/42 | 1.34 (0.74-2.46) | .04 |
| MTHFR Ex8-62A>C (1298A>C) | ||||
| AA | 104/77 | 79/58 | 1.04 (0.66-1.63) | |
| AC | 92/72 | 73/69 | 0.93 (0.58-1.49) | |
| CC | 27/11 | 8/27 | 0.13 (0.04-0.39) | .007 |
| MTRR Ex5+136T>C | ||||
| TT | 165/108 | 113/122 | 0.67 (0.47-0.97) | |
| CT/CC | 57/48 | 45/30 | 1.28 (0.69-2.35) | .05 |
| Nutritional factor, genotype . | Dietary intake levels of nutrients . | P interaction . | ||
|---|---|---|---|---|
| Low, less than median . | High, median or higher . | |||
| No. of cases/controls* . | No. of cases/controls* . | OR (95% CI) . | ||
| Vitamin B6 | ||||
| Combined genotypes | 237/162 | 149/157 | 0.70 (0.51-0.95) | N/A |
| FPGS Ex15-263T>C | ||||
| TT | 69/59 | 57/49 | 1.03 (0.61-1.74) | |
| CT | 104/81 | 67/79 | 0.71 (0.46-1.12) | |
| CC | 59/17 | 20/27 | 0.22 (0.10-0.52) | .002 |
| MTHFS IVS2-1411T>G | ||||
| TT/TG | 149/89 | 85/99 | 0.54 (0.36-0.81) | |
| GG | 18/26 | 14/16 | 1.68 (0.61-4.65) | .06 |
| MTR Ex26-20A>G | ||||
| AA | 117/78 | 69/91 | 0.55 (0.35-0.86) | |
| AG/GG | 50/44 | 36/28 | 1.20 (0.62-2.33) | .05 |
| Methionine | ||||
| Combined genotypes | 225/164 | 161/155 | 0.82 (0.60-1.11) | N/A |
| FTHFD Ex10-40G>T | ||||
| GG | 179/112 | 105/112 | 0.63 (0.44-0.91) | |
| GT/TT | 43/44 | 51/42 | 1.34 (0.74-2.46) | .04 |
| MTHFR Ex8-62A>C (1298A>C) | ||||
| AA | 104/77 | 79/58 | 1.04 (0.66-1.63) | |
| AC | 92/72 | 73/69 | 0.93 (0.58-1.49) | |
| CC | 27/11 | 8/27 | 0.13 (0.04-0.39) | .007 |
| MTRR Ex5+136T>C | ||||
| TT | 165/108 | 113/122 | 0.67 (0.47-0.97) | |
| CT/CC | 57/48 | 45/30 | 1.28 (0.69-2.35) | .05 |
Unconditional logistic regression model adjusted for age at study entry (continuous), sex, race (white, non-African American others), and mutually for dietary intake of methionine and vitamin B6. Median dietary intake is defined as 0.97 mg/1000 kcal for vitamin B6 and 0.97 g/1000 kcal for methionine.
For low dietary intakes of both vitamin B6 and methionine, all ORs were 1.0 (reference).
Counts of cases and controls vary across polymorphisms due to (1) two-step genotyping strategy (genotyping was not completed for certain polymorphisms [Table 1] in participants who provided only buccal cell samples [∼25%] if genotype information from blood-based DNA samples did not yield significant or suggestive associations with overall NHL) and (2) error in genotyping or insufficient DNA (2%-4% in general).