Table 3

Distribution of IGHV3-21 in the main Italian geographic areas

IGHV3-21 B-CLLs with homHCDR3*PIGHV3-21 B-CLLs with nonhomHCDR3*PIGHV3-21 B-CLLs with homHCDR3 + nonhomHCDR3*P
Northern Italy 16/530 .002 7/530 .39 23/530 .15 
Central Southern Italy 2/546 — 12/546 — 14/546 — 
IGHV3-21 B-CLLs with homHCDR3*PIGHV3-21 B-CLLs with nonhomHCDR3*PIGHV3-21 B-CLLs with homHCDR3 + nonhomHCDR3*P
Northern Italy 16/530 .002 7/530 .39 23/530 .15 
Central Southern Italy 2/546 — 12/546 — 14/546 — 

— indicates not applicable.

*

Number of cases in a given CLL subgroup over the total number of CLLs in the specific geographic area.

P values obtained by the Pearson χ2 test with Yates continuity correction, comparing Northern versus Central Southern Italy CLL subgroups.

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