Recipients of CD4+ memory T cells do not have histological GVHD
| Group . | GVHD scores . | ||
|---|---|---|---|
| Skin . | Liver . | Colon . | |
| TCD BM only, n = 5 | |||
| Mouse 1 | 0 | 0 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0 | 0.5 | 0 |
| Mouse 4 | 0.5 | 0 | 0 |
| Mouse 5 | 0 | 0 | 0 |
| CD4+ naive, n = 5 | |||
| Mouse 1 | 0.5 | 8 | 7 |
| Mouse 2 | 0.5 | 8 | 8 |
| Mouse 3 | 1 | 6 | ND |
| Mouse 4 | 1 | 6 | ND |
| Mouse 5 | 0 | 6 | 8 |
| CD4+ memory, n = 5 | |||
| Mouse 1 | 0.5 | 0 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0 | 0 | 0 |
| Mouse 4 | 0.5 | 0 | 0.5 |
| Mouse 5 | ND | 0 | 0 |
| Group . | GVHD scores . | ||
|---|---|---|---|
| Skin . | Liver . | Colon . | |
| TCD BM only, n = 5 | |||
| Mouse 1 | 0 | 0 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0 | 0.5 | 0 |
| Mouse 4 | 0.5 | 0 | 0 |
| Mouse 5 | 0 | 0 | 0 |
| CD4+ naive, n = 5 | |||
| Mouse 1 | 0.5 | 8 | 7 |
| Mouse 2 | 0.5 | 8 | 8 |
| Mouse 3 | 1 | 6 | ND |
| Mouse 4 | 1 | 6 | ND |
| Mouse 5 | 0 | 6 | 8 |
| CD4+ memory, n = 5 | |||
| Mouse 1 | 0.5 | 0 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0 | 0 | 0 |
| Mouse 4 | 0.5 | 0 | 0.5 |
| Mouse 5 | ND | 0 | 0 |
Tissues were harvested from representative mice shown in Figure 6. Tissues from recipients of CD4+ naive T cells were harvested between day 8 and day 9. Tissues from recipients of TCD BM only and memory T cells were harvested after recipients were electively killed on day 182. Shown are individual scores of maximum scores of 12 for each target organ.
TCD BM indicates T-cell-depleted BM; ND, not determined.