Recipients of memory T cells do not have histological GVHD
| Group . | GVHD scores . | ||
|---|---|---|---|
| Skin . | Liver . | Colon . | |
| TCD BM only, n = 4 | |||
| Mouse 1 | 0.5 | 0.5 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0.5 | 0.5 | 0 |
| Mouse 4 | 0.5 | 0 | 0 |
| Bulk, n = 3 | |||
| Mouse 1 | 5 | 9 | 5 |
| Mouse 2 | 0.5 | 6.5 | 7 |
| Mouse 3 | 0 | 2.5 | 7 |
| Naive, n = 3 | |||
| Mouse 1 | 3.5 | 6.5 | 7 |
| Mouse 2 | 0 | 8 | 7 |
| Mouse 3 | 2 | 1.5 | 8 |
| Memory, n = 4 | |||
| Mouse 1 | 0 | 0.5 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0.5 | 0.5 | 0 |
| Mouse 4 | 0.5 | 0 | 0 |
| Group . | GVHD scores . | ||
|---|---|---|---|
| Skin . | Liver . | Colon . | |
| TCD BM only, n = 4 | |||
| Mouse 1 | 0.5 | 0.5 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0.5 | 0.5 | 0 |
| Mouse 4 | 0.5 | 0 | 0 |
| Bulk, n = 3 | |||
| Mouse 1 | 5 | 9 | 5 |
| Mouse 2 | 0.5 | 6.5 | 7 |
| Mouse 3 | 0 | 2.5 | 7 |
| Naive, n = 3 | |||
| Mouse 1 | 3.5 | 6.5 | 7 |
| Mouse 2 | 0 | 8 | 7 |
| Mouse 3 | 2 | 1.5 | 8 |
| Memory, n = 4 | |||
| Mouse 1 | 0 | 0.5 | 0 |
| Mouse 2 | 0 | 0.5 | 0 |
| Mouse 3 | 0.5 | 0.5 | 0 |
| Mouse 4 | 0.5 | 0 | 0 |
Tissues were harvested from representative mice shown in Figure 2A (C57BL/6→BALB/c). Similar results were observed in 2 other systems (BALB/c→C57BL/6 and C57BL/6→C3H/HeJ). Tissues from recipients of bulk and naive T cells were harvested between days 23 and 36. Tissues from TCD BM only and memory T-cell recipients were harvested after recipients were electively killed on day 120. Shown are individual scores of maximum scores of 12 for each target organ.
TCD BM indicates T-cell-depleted BM.