Comparative toxicity of COPADM courses
| . | First COPADM: B1, B2, B3, B4 . | Second COPADM, full-dose CPM: B1, B2 . | Second COPADM, half-dose CPM: B3, B4 . | M1: B1, B3 . | |
|---|---|---|---|---|---|
| N | 637 | 320 | 313 | 298 | |
| Cyclophosphamide, total dose; fractions | 1.5 g/m2; 6 every 12 h | 3 g/m2; 6 every 12 h | 1.5 g/m2; 6 every 12 h | 1 g/m2; 2 at 24 h | |
| 1 or more toxicity grade 3-4, no. (%) | 481 (76) | 248 (78) | 206 (66)* | 127 (43) | |
| 1 or more toxicity grade 4, no. (%) | 181 (28) | 86 (27) | 66 (21)† | 30 (10) | |
| Infection grade 4, no. (%) | 49 (8) | 29 (9) | 19 (6) | 9 (3) | |
| Stomatitis, no. (%) | |||||
| Grade 3 | 139 (22) | 78 (24) | 54 (17) | 24 (8) | |
| Grade 4 | 132 (21) | 57 (18) | 43 (14)‡ | 17 (6) | |
| Intensive care, no. (%) | 36 (6) | 20 (6) | 5 (2)‡ | 5 (2) | |
| . | First COPADM: B1, B2, B3, B4 . | Second COPADM, full-dose CPM: B1, B2 . | Second COPADM, half-dose CPM: B3, B4 . | M1: B1, B3 . | |
|---|---|---|---|---|---|
| N | 637 | 320 | 313 | 298 | |
| Cyclophosphamide, total dose; fractions | 1.5 g/m2; 6 every 12 h | 3 g/m2; 6 every 12 h | 1.5 g/m2; 6 every 12 h | 1 g/m2; 2 at 24 h | |
| 1 or more toxicity grade 3-4, no. (%) | 481 (76) | 248 (78) | 206 (66)* | 127 (43) | |
| 1 or more toxicity grade 4, no. (%) | 181 (28) | 86 (27) | 66 (21)† | 30 (10) | |
| Infection grade 4, no. (%) | 49 (8) | 29 (9) | 19 (6) | 9 (3) | |
| Stomatitis, no. (%) | |||||
| Grade 3 | 139 (22) | 78 (24) | 54 (17) | 24 (8) | |
| Grade 4 | 132 (21) | 57 (18) | 43 (14)‡ | 17 (6) | |
| Intensive care, no. (%) | 36 (6) | 20 (6) | 5 (2)‡ | 5 (2) | |