Table 1

Hemodynamics of sickle mice show pulmonary hypertension and age-related heart failure; n = 4 to 7 per group

Mice 3 to 5 mo of age
Mice 13 to 15 mo of age
HemizygousSickleHemizygousSickle
Pulmonary arterial pressure, mm Hg 
    Systolic 12.7 ± 0.8 23.0 ± 0.6 13.9 ± 0.7 22.2 ± 0.5 
    Diastolic 6.8 ± 0.8 15.3 ± 0.7 8.1 ± 0.4 13.8 ± 0.7 
Pulmonary vascular resistance, mm Hg/mL/min 0.37 ± .05 0.80 ± .07* 0.36 ± .06 0.75 ± .04* 
Mean right atrial pressure, mm Hg 4.1 ± 0.3 4.3 ± 0.4 4.0 ± 0.9 6.5 ± 0.8*† 
Cardiac output, mL/min 13.7 ± 1.9 17.1 ± 2.3* 14.7 ± 1.2 12.2 ± 2.1*† 
Total peripheral resistance, mm Hg/mL/min 5.8 ± 0.5 4.1 ± 0.6 5.7 ± 0.8 7.2 ± 0.6* 
Systemic systolic pressure, mm Hg 103 ± 5 99 ± 9 109 ± 7 119 ± 12 
Systemic diastolic pressure, mm Hg 76 ± 6 71 ± 8 81 ± 6 87 ± 8 
Mean systemic arterial pressure, mm Hg 83 ± 6 74 ± 8 88 ± 8 94 ± 9 
Heart rate, bpm 600 ± 29 639 ± 30 605 ± 24 611 ± 28 
Mice 3 to 5 mo of age
Mice 13 to 15 mo of age
HemizygousSickleHemizygousSickle
Pulmonary arterial pressure, mm Hg 
    Systolic 12.7 ± 0.8 23.0 ± 0.6 13.9 ± 0.7 22.2 ± 0.5 
    Diastolic 6.8 ± 0.8 15.3 ± 0.7 8.1 ± 0.4 13.8 ± 0.7 
Pulmonary vascular resistance, mm Hg/mL/min 0.37 ± .05 0.80 ± .07* 0.36 ± .06 0.75 ± .04* 
Mean right atrial pressure, mm Hg 4.1 ± 0.3 4.3 ± 0.4 4.0 ± 0.9 6.5 ± 0.8*† 
Cardiac output, mL/min 13.7 ± 1.9 17.1 ± 2.3* 14.7 ± 1.2 12.2 ± 2.1*† 
Total peripheral resistance, mm Hg/mL/min 5.8 ± 0.5 4.1 ± 0.6 5.7 ± 0.8 7.2 ± 0.6* 
Systemic systolic pressure, mm Hg 103 ± 5 99 ± 9 109 ± 7 119 ± 12 
Systemic diastolic pressure, mm Hg 76 ± 6 71 ± 8 81 ± 6 87 ± 8 
Mean systemic arterial pressure, mm Hg 83 ± 6 74 ± 8 88 ± 8 94 ± 9 
Heart rate, bpm 600 ± 29 639 ± 30 605 ± 24 611 ± 28 

Numbers are mean ± SEM; P < .05 by t test. Statistically significant results by t test are denoted as

*

P < .05 for sickle versus age-matched hemizygotes and

†

P < .05 for young versus old mice.

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