Studies evaluating thrombophilia as risk factor for splanchnic vein thrombosis
| First author (reference) . | Patients/controls . | Risk factors analyzed . | Main results . |
|---|---|---|---|
| Janssen (33) | 43/474 | FVL, PT, PC, PS, AT | FVL associated with 11-fold, PC with 7-fold increased risk for Budd-Chiari syndrome |
| 92/474 | FVL, PT, PC, PS, AT | FVL associated with 3-fold, PC with 5-fold increased risk for PVT | |
| Primignani (34) | 65/700 | FVL, PT, PC, PS, AT, HHcy | PT associated with 8-fold, PC-PS-AT with 4.5-fold increased risk for PVT |
| Amitrano (35) | 12/431 | FVL, PT, MTHFR C677T | FVL associated with 6-fold, PT with 7-fold and MTHFR TT677 with 4.5-fold increased risk of MVT |
| Denninger (36) | 68/0 | FVL, PT, PC, PS, MTHFR C677T, APA | One or more prothrombotic disorders found in 72% of patients with PVT and 87% of patients with HVT |
| Madonna (37) | 10/259 | FVL, PT, PC, PS, AT, MTHFR C677T, APA | PT mutation found in 40% of patients with PVT and 6% of controls (P < .01). |
| First author (reference) . | Patients/controls . | Risk factors analyzed . | Main results . |
|---|---|---|---|
| Janssen (33) | 43/474 | FVL, PT, PC, PS, AT | FVL associated with 11-fold, PC with 7-fold increased risk for Budd-Chiari syndrome |
| 92/474 | FVL, PT, PC, PS, AT | FVL associated with 3-fold, PC with 5-fold increased risk for PVT | |
| Primignani (34) | 65/700 | FVL, PT, PC, PS, AT, HHcy | PT associated with 8-fold, PC-PS-AT with 4.5-fold increased risk for PVT |
| Amitrano (35) | 12/431 | FVL, PT, MTHFR C677T | FVL associated with 6-fold, PT with 7-fold and MTHFR TT677 with 4.5-fold increased risk of MVT |
| Denninger (36) | 68/0 | FVL, PT, PC, PS, MTHFR C677T, APA | One or more prothrombotic disorders found in 72% of patients with PVT and 87% of patients with HVT |
| Madonna (37) | 10/259 | FVL, PT, PC, PS, AT, MTHFR C677T, APA | PT mutation found in 40% of patients with PVT and 6% of controls (P < .01). |
FVL indicates factor V Leiden; PT, prothrombin G20210A mutation; PC, protein C deficiency; PS, protein S deficiency; AT, antithrombin deficiency; HHcy, hyperhomocysteinemia; MTHFR, methylenetetrahydrofolate reductase; PVT, portal vein thrombosis; MVT, mesenteric vein thrombosis; APA, antiphospholipid antibodies; and HVT, hepatic vein thrombosis.