Serum asparagine deamination (depletion) at different time intervals after drug administration
Time . | No. of patients tested . | Asparagine deamination, no. of patients (%) . |
---|---|---|
2 h | 14 | 14 (100) |
Day 7 | 16 | 16 (100) |
Day 14 | 12 | 12 (100) |
Days 20-21 | 11 | 9 (82) |
Days 26-28 | 9 | 4 (44) |
Time . | No. of patients tested . | Asparagine deamination, no. of patients (%) . |
---|---|---|
2 h | 14 | 14 (100) |
Day 7 | 16 | 16 (100) |
Day 14 | 12 | 12 (100) |
Days 20-21 | 11 | 9 (82) |
Days 26-28 | 9 | 4 (44) |
Samples were obtained from 19 adult patients after a single IV dose (2000/IU/m2) of pegaspargase. Serum asparagine concentration of less than 3 μM is considered optimal deamination.44