Table 2

Serum asparagine deamination (depletion) at different time intervals after drug administration

TimeNo. of patients testedAsparagine deamination, no. of patients (%)
2 h 14 14 (100) 
Day 7 16 16 (100) 
Day 14 12 12 (100) 
Days 20-21 11 9 (82) 
Days 26-28 4 (44) 
TimeNo. of patients testedAsparagine deamination, no. of patients (%)
2 h 14 14 (100) 
Day 7 16 16 (100) 
Day 14 12 12 (100) 
Days 20-21 11 9 (82) 
Days 26-28 4 (44) 

Samples were obtained from 19 adult patients after a single IV dose (2000/IU/m2) of pegaspargase. Serum asparagine concentration of less than 3 μM is considered optimal deamination.44 

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