Table 1 Ectopic RXRα and LG100268... | American Society of Hematology

Table 1

Ectopic RXRα and LG100268 cooperatively augment CD14⁺CD11b⁺ Mo's

Experiment no.	CD11b⁺CD14⁺, %*
	Control			RXRα
	Vehicle	LG100268	VD3	Vehicle	LG100268	VD3
1†	77	77	88	93	94	95
2	87	90	93	90	90	96
3	64	70	77	79	89	93
4	84	85	ND	93	96	98
5	79	88	90	89	95	95
6	75	78	89	76	93	93

Experiment no.	CD11b⁺CD14⁺, %*
	Control			RXRα
	Vehicle	LG100268	VD3	Vehicle	LG100268	VD3
1†	77	77	88	93	94	95
2	87	90	93	90	90	96
3	64	70	77	79	89	93
4	84	85	ND	93	96	98
5	79	88	90	89	95	95
6	75	78	89	76	93	93

CD34⁺ cells were transduced with empty control or RXRα-encoding vectors under progenitor expansion conditions. After transduction (48 hours), cells were replated in serum-free Mo-specific cultures in the absence (Vehicle) or presence of LG100268 or VD3 as indicated. ND indicates not determined.

GFP⁺ cells were analyzed by FACS for CD11b and CD14.

†

Six independent cord blood donor experiments are shown.

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