Table 3 Functional gene clusters... | American Society of Hematology

Table 3

Functional gene clusters overrepresented

	Z score	P	% of selection	% of all
Functional gene clusters overrepresented among up-regulated genes
Molecular function
Receptor activity	2.91	.013	19.5	10.2
Interleukin-1 receptor activity	11.76	<.001	3.4	0.1
Biological process
Immune response	5.71	<.001	20.7	6.1
Innate immune response	5.42	<.001	9.2	1.7
Chemotaxis	2.48	.04	3.4	0.9
Cell communication	2.39	.015	35.6	24.6
Intracellular signaling cascade	2.41	.018	13.8	7.2
MAPKKK cascade	3.99	.006	3.4	0.5
G-protein signaling, coupled to cAMP nucleotide second messenger	3.59	.009	3.4	0.6
Negative regulation of cell proliferation	2.95	.016	4.6	1.2
Cell activation	3.22	.03	3.4	0.7
Lymphocyte activation	3.64	.017	3.4	0.6
Cell motility	2.29	.026	6.9	2.8
Anti-inflammation/immunosuppression *	7.28	<.001	6.7	0.74
Phagocytosis*	5.21	<.001	5	0.69
Functional gene clusters overrepresented among down-regulated genes
Molecular function
Receptor activity	2.42	.022	21.4	10.2
Chemokine activity	11.63	<.001	11.9	0.4
Biological process
Immune response	11.27	<.001	47.6	6.1
Humoral immune response	3.02	.031	7.1	1.5
Innate immune response	7.51	<.001	16.7	1.7
Negative regulation of cell proliferation	3.57	.013	7.1	1.2
Cell communication	2.75	.011	42.9	24.6
Cell-cell signaling	3.63	.005	16.7	4.8
Cell adhesion	2.88	.011	14.3	4.8
Signal transduction	2.66	.014	35.7	19.5
Apoptosis	2.98	.015	11.9	3.5
Cell motility	2.61	.034	9.5	2.8
Oxidative*	3.18	.004	13.3	4.0
IFNγ induced*	13.04	<.001	15.5	0.6
Phagocytosis*	4.87	<.001	6.7	0.69

	Z score	P	% of selection	% of all
Functional gene clusters overrepresented among up-regulated genes
Molecular function
Receptor activity	2.91	.013	19.5	10.2
Interleukin-1 receptor activity	11.76	<.001	3.4	0.1
Biological process
Immune response	5.71	<.001	20.7	6.1
Innate immune response	5.42	<.001	9.2	1.7
Chemotaxis	2.48	.04	3.4	0.9
Cell communication	2.39	.015	35.6	24.6
Intracellular signaling cascade	2.41	.018	13.8	7.2
MAPKKK cascade	3.99	.006	3.4	0.5
G-protein signaling, coupled to cAMP nucleotide second messenger	3.59	.009	3.4	0.6
Negative regulation of cell proliferation	2.95	.016	4.6	1.2
Cell activation	3.22	.03	3.4	0.7
Lymphocyte activation	3.64	.017	3.4	0.6
Cell motility	2.29	.026	6.9	2.8
Anti-inflammation/immunosuppression *	7.28	<.001	6.7	0.74
Phagocytosis*	5.21	<.001	5	0.69
Functional gene clusters overrepresented among down-regulated genes
Molecular function
Receptor activity	2.42	.022	21.4	10.2
Chemokine activity	11.63	<.001	11.9	0.4
Biological process
Immune response	11.27	<.001	47.6	6.1
Humoral immune response	3.02	.031	7.1	1.5
Innate immune response	7.51	<.001	16.7	1.7
Negative regulation of cell proliferation	3.57	.013	7.1	1.2
Cell communication	2.75	.011	42.9	24.6
Cell-cell signaling	3.63	.005	16.7	4.8
Cell adhesion	2.88	.011	14.3	4.8
Signal transduction	2.66	.014	35.7	19.5
Apoptosis	2.98	.015	11.9	3.5
Cell motility	2.61	.034	9.5	2.8
Oxidative*	3.18	.004	13.3	4.0
IFNγ induced*	13.04	<.001	15.5	0.6
Phagocytosis*	4.87	<.001	6.7	0.69

Additional functional clusters identified by literature database search.