Evaluation for good-risk ALL prognostic factors in NCI standard risk (evaluable cytogenetics; excludes those with fewer than 45 chromosomes and Ph-positive ALL; POG 1988 to 1999 and CCG 1996 to 2000)
| Group . | No. patients . | 5-Y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | |
| Trisomies 4, 10, and 17 | 747 | 108 | 89.3 (1.4) | 91.5 (2.8) | 88.3 (2.1) | 91.5 (3.7) |
| Other* | 2706 | 655 | 76.6 (1.0) | 78.6 (1.7) | 74.1 (1.3) | 77.0 (2.3) |
| TEL/AML1† | 115 | 81 | 85.1 (10.4) | 86.2 (4.0) | NA | 86.2 (16.0) |
| Other* | 345 | 359 | 77.7 (6.8) | 80.5 (2.3) | NA | 78.4 (12.2) |
| Group . | No. patients . | 5-Y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | |
| Trisomies 4, 10, and 17 | 747 | 108 | 89.3 (1.4) | 91.5 (2.8) | 88.3 (2.1) | 91.5 (3.7) |
| Other* | 2706 | 655 | 76.6 (1.0) | 78.6 (1.7) | 74.1 (1.3) | 77.0 (2.3) |
| TEL/AML1† | 115 | 81 | 85.1 (10.4) | 86.2 (4.0) | NA | 86.2 (16.0) |
| Other* | 345 | 359 | 77.7 (6.8) | 80.5 (2.3) | NA | 78.4 (12.2) |
All patients were in the standard risk group.
NA indicates not applicable.
Those with evaluable cytogenetics that do not have traits listed above it for those risk groups (hypodiploid and t(9;22) excluded). Twelve patients with trisomies 4, 10, and 17 had extramedulary disease (EMD) (CNS or testicular), and all but one are in continuous complete remission (CCR).
TEL/AML1 status was determined retrospectively in a subset of the patients on POG studies 9201, 9405, and 9605 (using Southern blot) and the CCG 1952 study.