Evaluation of rapidity of response as an ALL prognostic factor (evaluable cytogenetics; excludes those with fewer than 45 chromosomes and Ph-positive ALL; CCG 1952 [1996 to 2000] and CCG 1961 [1996 to 2002])
| Group . | NCI risk group . | No patients. . | 5-y EFS (SE) . | 8-y EFS (SE) . |
|---|---|---|---|---|
| Day-7 marrow | ||||
| RER, M1/M2 | Standard | 713 | 84.3 (1.6) | 82.0 (8.0) |
| SER, M3 | Standard | 233 | 75.7 (3.1) | 74.6 (12.5) |
| RER, M1/M2 | High | 704 | 76.4 (2.5) | 74.6 (21.7) |
| SER, M3 | High | 268 | 69.4 (4.8) | 60.7 (38.0) |
| Day-14* marrow | ||||
| RER, M1* | Standard | 835 | 84.4 (1.4) | 82.4 (6.7) |
| SER, M2/M3 | Standard | 107 | 66.6 (5.0) | 65.4 (38.5) |
| RER, M1* | High | 819 | 77.0 (2.4) | 73.4 (21.9) |
| SER, M2/M3 | High | 113 | 59.0 (7.4) | 59.0 (37.8) |
| Group . | NCI risk group . | No patients. . | 5-y EFS (SE) . | 8-y EFS (SE) . |
|---|---|---|---|---|
| Day-7 marrow | ||||
| RER, M1/M2 | Standard | 713 | 84.3 (1.6) | 82.0 (8.0) |
| SER, M3 | Standard | 233 | 75.7 (3.1) | 74.6 (12.5) |
| RER, M1/M2 | High | 704 | 76.4 (2.5) | 74.6 (21.7) |
| SER, M3 | High | 268 | 69.4 (4.8) | 60.7 (38.0) |
| Day-14* marrow | ||||
| RER, M1* | Standard | 835 | 84.4 (1.4) | 82.4 (6.7) |
| SER, M2/M3 | Standard | 107 | 66.6 (5.0) | 65.4 (38.5) |
| RER, M1* | High | 819 | 77.0 (2.4) | 73.4 (21.9) |
| SER, M2/M3 | High | 113 | 59.0 (7.4) | 59.0 (37.8) |
These data were obtained from patients treated on CCG 1961 high-risk (n = 946) and CCG 1952 standard-risk (n = 1874) protocols only because day-7 and -14 marrow response data were not available on earlier studies. These data are not available for POG studies.
Day-14 bone marrows were not performed if the day 7 bone marrow was M1. Day-7 M1 marrows were included in the M1 marrows at day 14.