Evaluation of clinical factors as potential ALL high-risk prognostic factors (all patients with evaluable cytogenetics; POG 1986 to 1999 and CCG 1988 to 1995)
| Group . | NCI risk group . | No. patients . | 5-y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | ||
| Sex | |||||||
| Male | High | 849 | 208 | 54.1 (2.2) | 68.5 (3.4) | 49.3 (3.0) | 65.7 (5.1) |
| Female | High | 680 | 198 | 67.1 (2.3) | 69.8 (3.4) | 63.2 (3.3) | 67.4 (4.9) |
| Race | |||||||
| African American | High | 165 | 36 | 53.1 (5.0) | 56.9 (8.6) | 51.5 (6.8) | 53.4 (18.2) |
| Hispanic | High | 225 | 29 | 54.3 (4.8) | 67.7 (9.3) | 52.2 (9.3) | 67.7 (17.2) |
| Other | High | 1139 | 340 | 61.9 (1.8) | 70.7 (2.8) | 56.8 (2.5) | 68.0 (3.7) |
| Age | |||||||
| 15.00 y or less | High | 1360 | 343 | 60.9 (1.7) | 71.0 (2.6) | 56.7 (2.3) | 68.3 (3.7) |
| More than 15.00 y | High | 169 | 63 | 51.1 (5.4) | 59.0 (6.6) | 44.1 (8.2) | 57.0 (10.0) |
| WBC count | |||||||
| 200 × 109/L | High | 1421 | 367 | 61.6 (1.6) | 70.2 (2.5) | 56.8 (2.3) | 67.3 (3.7) |
| More than 200 × 109/L | High | 108 | 39 | 38.6 (6.0) | 58.5 (8.2) | 38.6 (8.4) | 58.5 (11.9) |
| CNS status at diagnosis* | |||||||
| CNS-1 | Any | 4382‡ | 1037 | 75.6 (7.9) | 78.4 (1.3) | 72.9 (1.1) | 76.6 (1.9) |
| CNS-2 | Any | 326 | 70 | 65.0 (3.4) | 67.0 (6.1) | 62.6 (5.3) | 67.0 (7.4) |
| CNS-3 | Any | 105‡ | 21 | 64.6 (5.4) | 76.2 (9.3) | 62.6 (7.0) | 76.8 (11.2) |
| CNS-1 | Standard | 3193 | 712 | 79.9 (0.9) | 81.2 (1.5) | 77.7 (1.2) | 79.6 (2.1) |
| CNS-2 | Standard | 176 | 38 | 70.1 (4.5) | 68.2 (8.0) | 69.1 (6.7) | 68.2 (10.3) |
| CNS-3 | Standard | 48 | 8 | 71.8 (7.6) | 75.0 (15.3) | 71.8 (9.5) | 75.0 (16.8) |
| CNS-1 | High | 1181 | 325 | 64.0 (1.8) | 72.2 (2.6) | 59.6 (2.5) | 69.8 (3.9) |
| CNS-2 | High | 150 | 32 | 59.0 (5.3) | 65.6 (9.3) | 54.8 (8.4) | 65.6 (10.7) |
| CNS-3 | High | 55 | 13 | 58.7 (7.5) | 76.9 (11.7) | 55.0 (9.9) | 76.9 (15.1) |
| Testicular status at diagnosis* | |||||||
| No disease | Any | 2667 | 618 | 71.4 (1.1) | 76.5 (1.8) | 68.4 (1.5) | 74.9 (2.4) |
| Disease† | Any | 10 | 8 | 90.0 (12.7) | 62.5 (17.1) | 90.0 (16.4) | 62.5 (17.1) |
| Group . | NCI risk group . | No. patients . | 5-y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | ||
| Sex | |||||||
| Male | High | 849 | 208 | 54.1 (2.2) | 68.5 (3.4) | 49.3 (3.0) | 65.7 (5.1) |
| Female | High | 680 | 198 | 67.1 (2.3) | 69.8 (3.4) | 63.2 (3.3) | 67.4 (4.9) |
| Race | |||||||
| African American | High | 165 | 36 | 53.1 (5.0) | 56.9 (8.6) | 51.5 (6.8) | 53.4 (18.2) |
| Hispanic | High | 225 | 29 | 54.3 (4.8) | 67.7 (9.3) | 52.2 (9.3) | 67.7 (17.2) |
| Other | High | 1139 | 340 | 61.9 (1.8) | 70.7 (2.8) | 56.8 (2.5) | 68.0 (3.7) |
| Age | |||||||
| 15.00 y or less | High | 1360 | 343 | 60.9 (1.7) | 71.0 (2.6) | 56.7 (2.3) | 68.3 (3.7) |
| More than 15.00 y | High | 169 | 63 | 51.1 (5.4) | 59.0 (6.6) | 44.1 (8.2) | 57.0 (10.0) |
| WBC count | |||||||
| 200 × 109/L | High | 1421 | 367 | 61.6 (1.6) | 70.2 (2.5) | 56.8 (2.3) | 67.3 (3.7) |
| More than 200 × 109/L | High | 108 | 39 | 38.6 (6.0) | 58.5 (8.2) | 38.6 (8.4) | 58.5 (11.9) |
| CNS status at diagnosis* | |||||||
| CNS-1 | Any | 4382‡ | 1037 | 75.6 (7.9) | 78.4 (1.3) | 72.9 (1.1) | 76.6 (1.9) |
| CNS-2 | Any | 326 | 70 | 65.0 (3.4) | 67.0 (6.1) | 62.6 (5.3) | 67.0 (7.4) |
| CNS-3 | Any | 105‡ | 21 | 64.6 (5.4) | 76.2 (9.3) | 62.6 (7.0) | 76.8 (11.2) |
| CNS-1 | Standard | 3193 | 712 | 79.9 (0.9) | 81.2 (1.5) | 77.7 (1.2) | 79.6 (2.1) |
| CNS-2 | Standard | 176 | 38 | 70.1 (4.5) | 68.2 (8.0) | 69.1 (6.7) | 68.2 (10.3) |
| CNS-3 | Standard | 48 | 8 | 71.8 (7.6) | 75.0 (15.3) | 71.8 (9.5) | 75.0 (16.8) |
| CNS-1 | High | 1181 | 325 | 64.0 (1.8) | 72.2 (2.6) | 59.6 (2.5) | 69.8 (3.9) |
| CNS-2 | High | 150 | 32 | 59.0 (5.3) | 65.6 (9.3) | 54.8 (8.4) | 65.6 (10.7) |
| CNS-3 | High | 55 | 13 | 58.7 (7.5) | 76.9 (11.7) | 55.0 (9.9) | 76.9 (15.1) |
| Testicular status at diagnosis* | |||||||
| No disease | Any | 2667 | 618 | 71.4 (1.1) | 76.5 (1.8) | 68.4 (1.5) | 74.9 (2.4) |
| Disease† | Any | 10 | 8 | 90.0 (12.7) | 62.5 (17.1) | 90.0 (16.4) | 62.5 (17.1) |
Excludes those with fewer than 45 chromosomes and Ph-positive ALL.
Six boys with testicular disease were known to be NCI standard risk, and 7 were NCI high risk. Two failed, one per risk group, both in year 1.
A total of 4813 POG patients (excluding those with fewer than 45 chromosomes and Ph-positive ALL) had a known CNS status at diagnosis. Of these, 10 patients (8 CNS-1 and 2 CNS-3) could not be classified into an NCI risk group due to missing WBC count at diagnosis and hence were included only in the overall (“Any”) analyses.