Evaluation of 11q23 and t(1;19) as an ALL prognostic factor in children more than 12 months of age (evaluable cytogenetics; excludes those with fewer than 45 chromosomes and Ph-positive ALL)
| Group and NCI risk group . | No. patients . | 5-y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | |
| t(4;11) | ||||||
| Any* | 44 | 13 | 49.9 (11.2) | 53.8 (14.9) | 49.9 (14.4) | 53.8 (21.1) |
| Standard | 6 | 4 | 50.0 (25.0) | 50.0 (35.4) | 50.0 (35.4) | ND |
| High | 38 | 9 | 49.9 (12.5) | 55.6 (16.6) | 49.9 (15.8) | 55.6 (21.4) |
| Other 11q23 | ||||||
| Any | 112 | 18 | 75.8 (4.9) | 71.8 (11.0) | 72.8 (7.4) | 71.8 (15.6) |
| Standard | 71 | 9 | 80.2 (5.6) | 66.7 (17.2) | 77.7 (8.9) | 66.7 (22.2) |
| High | 41 | 9 | 68.1 (9.3) | 77.8 (13.9) | 64.1 (12.8) | 51.9 (25.4) |
| Other† | ||||||
| Any | 4710 | 1107 | 74.8 (0.8) | 78.0 (1.3) | 72.1 (1.1) | 76.4 (1.8) |
| Standard | 3376 | 750 | 79.3 (0.8) | 80.8 (1.5) | 77.2 (1.2) | 79.3 (2.1) |
| High | 1323 | 357 | 63.3 (1.7) | 72.2 (2.5) | 58.9 (2.4) | 70.0 (3.6) |
| Balanced t(1;19) | ||||||
| Any‡ | 69 | 18 | 68.2 (7.3) | 50.0 (12.5) | 68.2 (10.3) | 50.0 (17.7) |
| Standard | 38 | 9 | 70.1 (9.3) | 44.4 (16.6) | 70.1 (12.1) | 44.4 (23.4) |
| High | 31 | 9 | 65.8 (11.6) | 55.6 (18.5) | 65.8 (19.2) | 55.6 (26.2) |
| Unbalanced t(1;19) | ||||||
| Any | 194 | 33 | 74.1 (4.1) | 81.8 (6.7) | 68.5 (6.1) | 81.8 (7.8) |
| Standard | 94 | 12 | 80.1 (5.1) | 83.3 (10.8) | 75.7 (7.3) | 83.3 (12.0) |
| High | 100 | 21 | 68.4 (6.6) | 81.0 (8.6) | 61.4 (10.2) | 81.0 (10.2) |
| Other† | ||||||
| Any | 4603§ | 1087 | 74.7 (0.8) | 78.0 (1.3) | 72.0 (1.1) | 76.3 (1.9) |
| Standard | 3321 | 742 | 79.3 (0.9) | 80.8 (1.5) | 77.2 (1.2) | 79.4 (2.1) |
| High | 1271 | 345 | 62.6 (1.7) | 71.8 (2.6) | 58.4 (2.4) | 69.5 (3.8) |
| Group and NCI risk group . | No. patients . | 5-y EFS (SE) . | 8-y EFS (SE) . | |||
|---|---|---|---|---|---|---|
| POG . | CCG . | POG . | CCG . | POG . | CCG . | |
| t(4;11) | ||||||
| Any* | 44 | 13 | 49.9 (11.2) | 53.8 (14.9) | 49.9 (14.4) | 53.8 (21.1) |
| Standard | 6 | 4 | 50.0 (25.0) | 50.0 (35.4) | 50.0 (35.4) | ND |
| High | 38 | 9 | 49.9 (12.5) | 55.6 (16.6) | 49.9 (15.8) | 55.6 (21.4) |
| Other 11q23 | ||||||
| Any | 112 | 18 | 75.8 (4.9) | 71.8 (11.0) | 72.8 (7.4) | 71.8 (15.6) |
| Standard | 71 | 9 | 80.2 (5.6) | 66.7 (17.2) | 77.7 (8.9) | 66.7 (22.2) |
| High | 41 | 9 | 68.1 (9.3) | 77.8 (13.9) | 64.1 (12.8) | 51.9 (25.4) |
| Other† | ||||||
| Any | 4710 | 1107 | 74.8 (0.8) | 78.0 (1.3) | 72.1 (1.1) | 76.4 (1.8) |
| Standard | 3376 | 750 | 79.3 (0.8) | 80.8 (1.5) | 77.2 (1.2) | 79.3 (2.1) |
| High | 1323 | 357 | 63.3 (1.7) | 72.2 (2.5) | 58.9 (2.4) | 70.0 (3.6) |
| Balanced t(1;19) | ||||||
| Any‡ | 69 | 18 | 68.2 (7.3) | 50.0 (12.5) | 68.2 (10.3) | 50.0 (17.7) |
| Standard | 38 | 9 | 70.1 (9.3) | 44.4 (16.6) | 70.1 (12.1) | 44.4 (23.4) |
| High | 31 | 9 | 65.8 (11.6) | 55.6 (18.5) | 65.8 (19.2) | 55.6 (26.2) |
| Unbalanced t(1;19) | ||||||
| Any | 194 | 33 | 74.1 (4.1) | 81.8 (6.7) | 68.5 (6.1) | 81.8 (7.8) |
| Standard | 94 | 12 | 80.1 (5.1) | 83.3 (10.8) | 75.7 (7.3) | 83.3 (12.0) |
| High | 100 | 21 | 68.4 (6.6) | 81.0 (8.6) | 61.4 (10.2) | 81.0 (10.2) |
| Other† | ||||||
| Any | 4603§ | 1087 | 74.7 (0.8) | 78.0 (1.3) | 72.0 (1.1) | 76.3 (1.9) |
| Standard | 3321 | 742 | 79.3 (0.9) | 80.8 (1.5) | 77.2 (1.2) | 79.4 (2.1) |
| High | 1271 | 345 | 62.6 (1.7) | 71.8 (2.6) | 58.4 (2.4) | 69.5 (3.8) |
ND indicates not done.
Data are from POG 1986 to 1999 and CCG 1988 to 1995.
t(4;11) versus 11q23 versus other; any (POG, P < .001; CCG, P = .004); standard risk (POG, P = .039; CCG, P = .002); high risk (POG, P = .009; CCG, P = .91).
Those with evaluable cytogenetics that do not have traits listed above it for those risk groups.
Balanced t(1;19) versus unbalanced t(1;19) versus other: any (POG, P = .235; CCG, P = .02); standard risk (POG, P = .294; CCG, P = .05); high risk (POG, P = .677; CCG, P = .41).
Eleven of the POG patients could not be classified into an NCI risk group due to missing WBC count at diagnosis and hence were included only in the overall (“Any”) analyses.